Cancer-associated fibroblasts reuse cancer-derived lactate to maintain a fibrotic and immunosuppressive microenvironment in pancreatic cancer

Kitamura, Fumimasa; Semba, Takashi; Yasuda-Yoshihara, Noriko; Yamada, Kosuke; Nishimura, Akiho; Yamasaki, Juntaro; Nagano, Osamu; Yasuda, Tadahito; Yonemura, Atsuko; Tong, Yilin; Wang, Huaitao; Akiyama, Takahiko; Matsumura, Kazuki; Uemura, Norio; Itoyama, Rumi; Bu, Luke; Fu, Lingfeng; Hu, Xichen; Wei, Feng; Mima, Kosuke; Imai, Katsunori; Hayashi, Hiromitsu; Yamashita, Yo-ichi; Miyamoto, Yuji; Baba, Hideo; Ishimoto, Takatsugu

doi:10.1172/jci.insight.163022

Cancer-associated fibroblasts reuse cancer-derived lactate to maintain a fibrotic and immunosuppressive microenvironment in pancreatic cancer

Glycolysis is highly enhanced in pancreatic ductal adenocarcinoma (PDAC) cells; thus, glucose restrictions are imposed on nontumor cells in the PDAC tumor microenvironment (TME). However, little is known about how such glucose competition alters metabolism and confers phenotypic changes in stroma…