Hypothalamic and brainstem glucose-dependent insulinotropic polypeptide receptor neurons employ distinct mechanisms to affect feeding

Adriaenssens, Alice; Broichhagen, Johannes; de Bray, Anne; Ast, Julia; Hasib, Annie; Jones, Ben; Tomas, Alejandra; Burgos, Natalie Figueredo; Woodward, Orla; Lewis, Jo; O’Flaherty, Elisabeth; El, Kimberley; Cui, Canqi; Harada, Norio; Inagaki, Nobuya; Campbell, Jonathan; Brierley, Daniel; Hodson, David J.; Samms, Ricardo; Gribble, Fiona; Reimann, Frank

doi:10.1172/jci.insight.164921

Hypothalamic and brainstem glucose-dependent insulinotropic polypeptide receptor neurons employ distinct mechanisms to affect feeding

Central glucose-dependent insulinotropic polypeptide (GIP) receptor (GIPR) signaling is critical in GIP-based therapeutics’ ability to lower body weight, but pathways leveraged by GIPR pharmacology in the brain remain incompletely understood. We explored the role of Gipr neurons in the hypothalam…