The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Claudin-low bladder tumors are immune infiltrated and actively immune suppressed
Open accessAbstract
We report the discovery of a claudin-low molecular subtype of high-grade bladder cancer that shares characteristics with the homonymous subtype of breast cancer. Claudin-low bladder tumors were enriched for multiple genetic features including increased rates of RB1 , EP300 , and NCOR1 mutations; increased frequency of EGFR amplification; decreased rates of FGFR3 , ELF3 , and KDM6A mutations; and decreased frequency of PPARG amplification. While claudin-low tumors showed the highest expression of immune gene signatures, they also demonstrated gene expression patterns consistent with those observed in active immunosuppression. This did not appear to be due to differences in predicted neoantigen burden, but rather was associated with broad upregulation of cytokine and chemokine levels from low PPARG activity, allowing unopposed NFKB activity. Taken together, these results define a molecular subtype of bladder cancer with distinct molecular features and an immunologic profile that would, in theory, be primed for immunotherapeutic response.
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PD-1 blockade induces responses by inhibiting adaptive immune resistance
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Neoantigens in cancer immunotherapy
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Comprehensive genomic characterization of squamous cell lung cancers
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Genomic correlates of response to CTLA-4 blockade in metastatic melanoma
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Saltz, J., Gupta, R., Hou, L., Kurc, T., Singh, P., Nguyen, V., Samaras, D., Shroyer, K. R., Zhao, T., Batiste, R., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.03.086 · Cited by 1,027
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Ricketts, C. J., De Cubas, A. A., Fan, H., Smith, C. C., Lang, M., Reznik, E., Bowlby, R., Gibb, E. A., Akbani, R., Beroukhim, R., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.06.032 · Cited by 734
Self-citationThe Claudins: From Tight Junctions to Biological Systems
Tsukita, S., Tanaka, H., & Tamura, A. (2019) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2018.09.008 · Cited by 470
New insights into the role of EMT in tumor immune escape
Terry, S., Savagner, P., Ortiz‐Cuaran, S., Mahjoubi, L., Saintigny, P., Thiery, J., & Chouaib, S. (2017) · Molecular Oncology · doi:10.1002/1878-0261.12093 · Cited by 414
Endogenous retroviral signatures predict immunotherapy response in clear cell renal cell carcinoma
Smith, C. C., Beckermann, K. E., Bortone, D. S., De Cubas, A. A., Bixby, L. M., Lee, S. J., Panda, A., Ganesan, S., Bhanot, G., Wallen, E. M., et al. (2018) · Journal of Clinical Investigation · doi:10.1172/jci121476 · Cited by 303
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Metadata
- Authors
- Kardos, J., Chai, S., Mose, L. E., Selitsky, S. R., Krishnan, B., Saito, R., Iglesia, M. D., Milowsky, M. I., Parker, J. S., Kim, W. Y., & Vincent, B. G.
- Venue
- JCI Insight
- Published
- 2016-03-17
- Volume
- 1
- Issue
- 3
- Pages
- e85902-e85902
- ISSN
- 2379-3708 (ISSN-L)
- OpenAlex
- W2301782847
- Cited by
- 207
- References
- 8
- FWCI
- 23.23
- Type
- journal article
- Language
- en
- Open access
- gold
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- Kardos, J., Chai, S., Mose, L. E., Selitsky, S. R., Krishnan, B., Saito, R., Iglesia, M. D., Milowsky, M. I., Parker, J. S., Kim, W. Y., & Vincent, B. G. (2016). Claudin-low bladder tumors are immune infiltrated and actively immune suppressed. JCI Insight. https://doi.org/10.1172/jci.insight.85902
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