The DOI matches its Crossref record; 95 of the 95 references it cites were found in a registry or an index.
Molecular characterization of the transition from acute to chronic kidney injury following ischemia/reperfusion
Open accessAbstract
Though an acute kidney injury (AKI) episode is associated with an increased risk of chronic kidney disease (CKD), the mechanisms determining the transition from acute to irreversible chronic injury are not well understood. To extend our understanding of renal repair, and its limits, we performed a detailed molecular characterization of a murine ischemia/reperfusion injury (IRI) model for 12 months after injury. Together, the data comprising RNA-sequencing (RNA-seq) analysis at multiple time points, histological studies, and molecular and cellular characterization of targeted gene activity provide a comprehensive profile of injury, repair, and long-term maladaptive responses following IRI. Tubular atrophy, interstitial fibrosis, inflammation, and development of multiple renal cysts were major long-term outcomes of IRI. Progressive proximal tubular injury tracks with de novo activation of multiple Krt genes, including Krt20, a biomarker of renal tubule injury. RNA-seq analysis highlights a cascade of temporal-specific gene expression patterns related to tubular injury/repair, fibrosis, and innate and adaptive immunity. Intersection of these data with human kidney transplant expression profiles identified overlapping gene expression signatures correlating with different stages of the murine IRI response. The comprehensive characterization of incomplete recovery after ischemic AKI provides a valuable resource for determining the underlying pathophysiology of human CKD.
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Cited by
Cell profiling of mouse acute kidney injury reveals conserved cellular responses to injury
Kirita, Y., Wu, H., Uchimura, K., Wilson, P. C., & Humphreys, B. D. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2005477117 · Cited by 650
Immune cells and inflammation in AKI to CKD progression
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GDF15: a hormone conveying somatic distress to the brain
Lockhart, S. M., Saudek, V., & O’Rahilly, S. (2020) · Endocrine Reviews · doi:10.1210/endrev/bnaa007 · Cited by 256
FOXM1 drives proximal tubule proliferation during repair from acute ischemic kidney injury
Chang-Panesso, M., Kadyrov, F. F., Lalli, M., Wu, H., Ikeda, S., Kefaloyianni, E., Abdelmageed, M. M., Herrlich, A., Kobayashi, A., & Humphreys, B. D. (2019) · Journal of Clinical Investigation · doi:10.1172/jci125519 · Cited by 158
Myofibroblast YAP/TAZ activation is a key step in organ fibrogenesis
He, X., Tolosa, M. F., Zhang, T., Goru, S. K., Ulloa Severino, L., Misra, P. S., McEvoy, C. M., Caldwell, L., Szeto, S. G., Gao, F., et al. (2022) · JCI Insight · doi:10.1172/jci.insight.146243 · Cited by 106
Metadata
- Authors
- Liu, J., Kumar, S., Dolzhenko, E., Alvarado, G. F., Guo, J., Lu, C., Chen, Y., Li, M., Dessing, M. C., Parvez, R. K., Cippà, P. E., Krautzberger, A. M., Saribekyan, G., Smith, A. D., & McMahon, A. P.
- Venue
- JCI Insight
- Published
- 2017-09-21
- Volume
- 2
- Issue
- 18
- ISSN
- 2379-3708 (ISSN-L)
- OpenAlex
- W2755721550
- Cited by
- 285
- References
- 95
- FWCI
- 14.25
- Type
- journal article
- Language
- en
- Open access
- gold
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- Liu, J., Kumar, S., Dolzhenko, E., Alvarado, G. F., Guo, J., Lu, C., Chen, Y., Li, M., Dessing, M. C., Parvez, R. K., Cippà, P. E., Krautzberger, A. M., Saribekyan, G., Smith, A. D., & McMahon, A. P. (2017). Molecular characterization of the transition from acute to chronic kidney injury following ischemia/reperfusion. JCI Insight. https://doi.org/10.1172/jci.insight.94716
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