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THE METABOLIC EFFECTS OF STEROID HORMONES IN OSTEOPOROSIS
Open accessAbstract
In a previous communication from this clinic (1), three metabolic studies on the effect of estradiol benzoate on the calcium and phosphorus metabolisms of patients with post-menopausal osteoporosis were published in abstract form.The first objective of the present paper is to report these studies in detail, supplemented by 2 additional studies: one in which testosterone propionate by itself, and in combination with estradiol benzoate, was used; and another in which diethylstilbestrol by itself, and in combination with progesterone, was employed.The subject of the 1 The expense of these studies was defrayed by grants from the Josiah Macy, Jr. Foundation, from the Rocke- feller Foundation, and from the National Research Coun- cil (Committee for Researchin the Problems of Sex).A bed supported by the Mallinckrodt Chemical Company on the Metabolic Ward was used for part of these studies. 2 Presented in part at the twenty-sixth annual meeting of the Association for the Study of Internal Secretions, Atlantic City, New Jersey, June 8, 1942, in connection with a symposium on "Relation of Endocrines to Skeletal Development"; an outline of this presentation may be found in: Reifenstein, E. C., Jr.; Albright, F.; Parson, W.; and Bloomberg, E.: The effect of estradiol benzoate and of testosterone propionate and of combinations of both on post-menopausal osteoporosis and senile osteo- porosis, Endocrinology, 30: S1024 (1942).Also presented in part at the first annual meeting of the Amnerican Federation for Clinical Research, Minneapolis, Minn., April 20, 1942.Preliminary reports of part of these data may be found in: Albright, F.;
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“This short summary clearly identifies androgens as anabolic hormones leading to storage of energy-rich substrates and calcium and phosphorus.”
From Interaction of the endocrine system with inflammation: a function of energy and volume regulation (2014) · cites this paper as [20]
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Albright, F., SMITH, P. H., & RICHARDSON, A. M. (1941) · JAMA · doi:10.1001/jama.1941.02820220007002 · Cited by 877
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Self-citationKlinefelter, H. F., Albright, F., & Griswold, G. C. (1943) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-3-10-529 · Cited by 392
Self-citationAcute Atrophy of Bone (Osteoporosis) Simulating Hyperparathyroidism12
Albright, F., BURNETT, C. H., Cope, O., & PARSON, W. (1941) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-1-9-711 · Cited by 202
Self-citationThe general adaptation syndrome and the diseases of adaptation
Selye, H. (1946) · Journal of Allergy · doi:10.1016/0021-8707(46)90148-7 · Cited by 150
THE COLORIMETRIC ASSAY OF URINARY CORTICOSTEROID-LIKE SUBSTANCES
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Self-citationShorr, E., Bernheim, A. R., & Taussky, H. H. (1942) · Science · doi:10.1126/science.95.2476.606 · Cited by 98
Reifenstein, E. C., & Albright, F. (1944) · New England Journal of Medicine · doi:10.1056/nejm194409072311001 · Cited by 78
Self-citationEFFECT OF METHYL TESTOSTERONE ON URINARY 17-KETOSTEROIDS OF ADRENAL ORIGIN 123
Reifenstein, E. C., Forbes, A. P., Albright, F., Donaldson, E., & Carroll, E. (1945) · Journal of Clinical Investigation · doi:10.1172/jci101620 · Cited by 53
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Research works printed but not linked: 16
- Albright, F., Bloomberg, E., and Smith, P. H., Post- menopausal osteoporosis. Tr. Assoc. Am. Physi- cians, 1940, 55, 298.
- Albright, F., Burnett, C. H., Cope, O., and Parson, W., Acute atrophy of bone (osteoporosis) simulat- ing hyperparathyroidism. J. Clin. Endocrinol., 1941, 1, 711.
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- Abels, J. C., and Dobriner, K., Conference on Meta- bolic Aspects of Convalescence Including Bone and Wound Healing, Transactions of Seventh Meeting, June 9-10, 1944, p. 122; distributed by Josiah Macy, Jr. Foundation, New York.
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- Browne, J. S. L., Conference on Metabolic Aspects of Convalescence Including Bone and Wound Heal- ing, Transactions of the Fifth Meeting, October 8-9, 1943, p. 91; distributed by Josiah Macy, Jr. Foundation, New York.
- Reifenstein, E. C., Jr., and Albright, F., Conferences on Metabolic Aspects of Convalescence Including Bone and Wound Healing, Transactions of the Fifth Meeting, October 8-9, 1943, p. 79; distributed by Josiah Macy, Jr. Foundation, New York.
- Fremont-Smith, M., Graham, R. M., Janzen, L. T., and Meigs, J. V., The vaginal smear in the diag- nosis of uterine cancer. J. Clin. Endocrinol., 1945, 5, 40.
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- Reifenstein, E. C., Jr., Albright, F., Parson, W., and Bloomberg, E., The effect of estradiol benzoate, of testosterone propionate, and of combinations of both on post-menopausal osteoporosis and senile osteoporosis. Endocrinol., 1942, 30, S1024.
- Reifenstein, E. C., Jr., and Albright, F., Conferences on Metabolic Aspects of Convalescence Including Bone and Wound Healing, Transactions of First Meeting, September 11-12, 1942, p. 37; Transac- tions of Second Meeting, December 11-12, 1942, p. 69 and 96; and Transactions of Fourth Meeting, June 11-12, 1943, p. 77; distributed by Josiah Macy, Jr. Foundation, New York.
- Reifenstein, E. C., Jr., and Albright, F., Conferences on Metabolic Aspects of Convalescence Including Bone and Wound Healing, Transactions of Third Meeting, March 12-13, 1943, p. 63; and Transac- tions of Fourth Meeting, June 11-12, 1943, p. 77; distributed by Josiah Macy, Jr. Foundation, New York.
- Reifenstein, E. C., Jr., and Albright, F., Conferences on Metabolic Aspects of Convalescence Including Bone and Wound Healing, Transactions of Fourth Meeting, June 11-12, 1943, p. 77; distributed by Josiah Macy, Jr. Foundation, New York.
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Zaidi, M., Sun, L., & Iqbal, J. Z. (2011) · Advances in experimental medicine and biology · doi:10.1007/978-1-4419-8002-1_26
Wirkungen der Gestagene auf den Stoffwechsel
Gibian, H., & Unger, R. (1968) · Springer eBooks · doi:10.1007/978-3-642-99941-3_4
Hirshland, H., & Hill, J. G. (1963) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(63)90428-9
Androgens and the Skeleton – Humans
Leder, B. Z. (2010) · Elsevier eBooks · doi:10.1016/b978-0-12-374602-3.00026-2
Age Differences in the Radiographic Density of Distal End of the Human Radius
Tanaka, S., Tsuyama, Y., Ikuta, H., Ikari, T., Kanazawa, M., & Kunitake, H. (1968) · Orthopedics & Traumatology · doi:10.5035/nishiseisai.18.49
Age Differences in the Radiographic Density of Human Lumbar Vertebrae
Tanaka, S., Ikuta, H., & Kanazawa, M. (1967) · Orthopedics & Traumatology · doi:10.5035/nishiseisai.17.94
Gonadal function and involution in man; and related practical management.
Engle, E. T., Buxton, C. L., Jailer, J. W., & Jn, R. (1957) · PubMed Central
Metadata
- Authors
- Reifenstein, E. C., & Albright, F.
- Affiliations
- Harvard University (US)
- Venue
- Journal of Clinical Investigation
- Published
- 1947-01-01
- Volume
- 26
- Issue
- 1
- Pages
- 24-56
- ISSN
- 0021-9738 (ISSN-L)
- PMC
- PMC435644
- OpenAlex
- W2097522558
- Cited by
- 217
- References
- 13
- Citations by year
- 2026: 2 · 2025: 1 · 2023: 1 · 2022: 1 · 2021: 3 · 2020: 5 · 2019: 3 · 2018: 5 · 2017: 3 · 2016: 4 · 2015: 4 · 2014: 3 · 2013: 6 · 2012: 6
- FWCI
- 39.94
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Clinical Investigation (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Massachusetts General Hospital
- Topics
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Menopause: Health Impacts and Treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
- Keywords
- postmenopausal osteoporosis, senile osteoporosis, steroid hormones, estradiol benzoate, testosterone propionate, diethylstilbestrol, progesterone, calcium metabolism, phosphorus metabolism, hormone therapy
- MeSH terms
- Atrophy, Bone and Bones, Hormones, Humans, Metabolism, Osteoporosis
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