The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.
THYROID FUNCTION IN NEPHROSIS 1
Open accessAbstract
Since hypometabolism and hypercholesterolemia are common to both hypothyroidism and nephro- sis, it was postulated that thyroid activity was sub- normal in nephrotic patients.However, Epstein found that remarkably large doses of thyroid hor- mone could be given to nephrotic patients without inducing hypermetabolism (1).Such tolerance to thyroid medication is unusual among patients with true hypothyroidism.It has therefore been sug- gested that the hypometabolism and increased se- rum cholesterol in nephrosis are due not to de- creased thyroid function but to other causes, as yet unknown (2).The recent demonstration that the concentra- tion of protein-bound iodine in the serum is re- duced in nephrosis (3) has once more raised the question of whether thyroid function is impaired in this syndrome.The present study is an at- tempt to answer this question. MATERIALS AND METHODSThe subjects for this study were patients in the active phase of the nephrotic syndrome with hypoproteinemia, proteinuria, and edema.All were hospitalized, eight at the Peter Bent Brigham Hospital, eight at the Presby- terian Hospital, and three at the Massachusetts General Hospital.The sex, age, and type of nephrosis are listed in Table I.The concentration of protein-bound iodine in the serum was determined by the method of Man, Smirnow, Gildea, and Peters (4).In certain patients the same method was used for the determination of protein-bound iodine in urine.The volume of urine used for analysis was so chosen as to contain approximately 0.4 gm. of protein.The urinary protein was precipitated with acid zinc sul- fate and sodium hydroxide, using the same quantities of
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“This is now widely accepted, at least for serum TH measurements, and serum fT4 should be measured in preference to TT4 despite its very low fraction of TT4 (0.03%).”
From Thyroid Stimulating Hormone and Thyroid Hormones (Triiodothyronine and Thyroxine): An American Thyroid Association-Commissioned Review of Current Clinical and Laboratory Status (2023) · cites this paper as [75]
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Cites
THE STATE OF CALCIUM IN THE FLUIDS OF THE BODY
McLean, F. C., & Hastings, A. B. (1935) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)75332-5 · Cited by 367
THE INTERACTIONS OF DRUGS AND PLASMA PROTEINS
GOLDSTEIN, A. (1949) · Pharmacological Reviews · doi:10.1016/s0031-6997(25)07064-4 · Cited by 261
The Effect on Endogenous Thyroid Activity of Feeding Desiccated Thyroid to Normal Human Subjects
Greer, M. A. (1951) · New England Journal of Medicine · doi:10.1056/nejm195103152441101 · Cited by 86
Werner, S. C., Quimby, E. H., & Schmidt, C. (1949) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-9-4-342 · Cited by 79
SERUM IODINE FRACTIONS IN HYPERTHYROIDISM 12
Man, E. B., Smirnow, A. E., Gildea, E. F., & Peters, J. P. (1942) · Journal of Clinical Investigation · doi:10.1172/jci101354 · Cited by 63
THE NATURE OF PLASMA IODINE AS REVEALED BY FILTER PAPER PARTITION CHROMATOGRAPHY
Taurog, A., Chaikoff, I. L., & Tong, W. (1950) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)51127-9 · Cited by 48
THE IODINE-DEFICIENT HUMAN THYROID GLAND. A PRELIMINARY REPORT*†
Stanbury, J. B., Brownell, G. L., Riggs, D. S., PERINETTI, H., del Castillo, E., Itoiz, J. E., Houssay, A. B., Trucco, E., & YACIOFANO, A. C. (1952) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-12-2-191 · Cited by 46
Self-citationTHE RELATION OF ALBUMIN TO PRECIPITABLE IODINE OF SERUM 1
Peters, J. P., & Man, E. B. (1948) · Journal of Clinical Investigation · doi:10.1172/jci101982 · Cited by 45
IODINE COMPOUNDS IN THE BLOOD AND URINE OF MAN*†§
Rall, J. E. (1950) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-10-9-996 · Cited by 43
THYROID THERAPY AND THYROID TOLERANCE IN CHRONIC NEPHROSIS
Epstein, A. A. (1926) · JAMA · doi:10.1001/jama.1926.02680120023007 · Cited by 41
Research works printed but not linked: 4
- Leiter, L., Nephrosis. Medicine, 1931, 10, 135.
- Peters, J. P., and Man, E. B., The relation of albu- min to precipitable iodine of serum. J. Clin. Invest., 1948, 27, 397.
- Man, E. B., Smirnow, A. E., Gildea, E. F., and Pe- ters, J. P., Serum iodine fractions in hyperthy- roidism. J. Clin. Invest., 1942, 21, 773.
- Wolbach, S. B., and Blackfan, K. D., Clinical and pathological studies on tubular nephritis (nephro- sis). Tr. A. Am. Physicians, 1929, 44, 77.
Cited by
Transthyretin (Prealbumin) in Health and Disease: Nutritional Implications
Ingenbleek, Y., & Young, V (1994) · Annual Review of Nutrition · doi:10.1146/annurev.nu.14.070194.002431 · Cited by 375
Bikle, D. D., & Schwartz, J. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00317 · Cited by 372
Role of Plasma Proteins in the Binding, Distribution and Metabolism of the Thyroid Hormones
Oppenheimer, J. H. (1968) · New England Journal of Medicine · doi:10.1056/nejm196805232782107 · Cited by 266
Xie, Z., Wang, X., & Bikle, D. D. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.00040 · Cited by 202
Bikle, D. D., Malmstroem, S., & Schwartz, J. B. (2017) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2017.07.013 · Cited by 130
Metadata
- Authors
- Recant, L., & Riggs, D. S.
- Affiliations
- Brigham and Women's Hospital (US)
- Venue
- Journal of Clinical Investigation
- Published
- 1952-08-01
- Volume
- 31
- Issue
- 8
- Pages
- 789-797
- ISSN
- 0021-9738 (ISSN-L)
- PMC
- PMC436475
- OpenAlex
- W1987825218
- Cited by
- 134
- References
- 19
- Citations by year
- 2025: 1 · 2024: 2 · 2023: 2 · 2022: 1 · 2021: 1 · 2020: 4 · 2019: 3 · 2018: 5 · 2017: 2 · 2015: 1 · 2013: 2
- FWCI
- 8.87
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Clinical Investigation (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Commonwealth Fund
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Health Sciences › Medicine › Nephrology › Renal Diseases and Glomerulopathies
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Keywords
- nephrotic syndrome, thyroid function, protein-bound iodine, hypothyroidism, hypometabolism, hypercholesterolemia, serum cholesterol
- MeSH terms
- Humans, Nephrosis, Thyroid Gland
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Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
