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Cited by 136Thyroid Disorders and TreatmentsRenal Diseases and GlomerulopathiesAdrenal Hormones and Disorders

The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.

THYROID FUNCTION IN NEPHROSIS 1

Open access
Recant, Lillian, Riggs, Douglas S.·1952·Journal of Clinical Investigation
DOI 10.1172/jci102664PMC PMC436475
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Abstract

Since hypometabolism and hypercholesterolemia are common to both hypothyroidism and nephro- sis, it was postulated that thyroid activity was sub- normal in nephrotic patients.However, Epstein found that remarkably large doses of thyroid hor- mone could be given to nephrotic patients without inducing hypermetabolism (1).Such tolerance to thyroid medication is unusual among patients with true hypothyroidism.It has therefore been sug- gested that the hypometabolism and increased se- rum cholesterol in nephrosis are due not to de- creased thyroid function but to other causes, as yet unknown (2).The recent demonstration that the concentra- tion of protein-bound iodine in the serum is re- duced in nephrosis (3) has once more raised the question of whether thyroid function is impaired in this syndrome.The present study is an at- tempt to answer this question. MATERIALS AND METHODSThe subjects for this study were patients in the active phase of the nephrotic syndrome with hypoproteinemia, proteinuria, and edema.All were hospitalized, eight at the Peter Bent Brigham Hospital, eight at the Presby- terian Hospital, and three at the Massachusetts General Hospital.The sex, age, and type of nephrosis are listed in Table I.The concentration of protein-bound iodine in the serum was determined by the method of Man, Smirnow, Gildea, and Peters (4).In certain patients the same method was used for the determination of protein-bound iodine in urine.The volume of urine used for analysis was so chosen as to contain approximately 0.4 gm. of protein.The urinary protein was precipitated with acid zinc sul- fate and sodium hydroxide, using the same quantities of

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Research works printed but not linked: 4

  1. Leiter, L., Nephrosis. Medicine, 1931, 10, 135.
  2. Peters, J. P., and Man, E. B., The relation of albu- min to precipitable iodine of serum. J. Clin. Invest., 1948, 27, 397.
  3. Man, E. B., Smirnow, A. E., Gildea, E. F., and Pe- ters, J. P., Serum iodine fractions in hyperthy- roidism. J. Clin. Invest., 1942, 21, 773.
  4. Wolbach, S. B., and Blackfan, K. D., Clinical and pathological studies on tubular nephritis (nephro- sis). Tr. A. Am. Physicians, 1929, 44, 77.

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Metadata

Authors
Recant, L., & Riggs, D. S.
Affiliations
Brigham and Women's Hospital (US)
Venue
Journal of Clinical Investigation
Publisher
American Society for Clinical Investigation
Published
1952-08-01
Volume
31
Issue
8
Pages
789-797
ISSN
0021-9738 (ISSN-L)
DOI
10.1172/jci102664
PMC
PMC436475
OpenAlex
W1987825218
Cited by
134
References
19
Citations by year
2025: 1 · 2024: 2 · 2023: 2 · 2022: 1 · 2021: 1 · 2020: 4 · 2019: 3 · 2018: 5 · 2017: 2 · 2015: 1 · 2013: 2
FWCI
8.87
Type
journal article
Language
en
Open access
Locations
  • Journal of Clinical Investigation (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
Commonwealth Fund
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
  • Health Sciences › Medicine › Nephrology › Renal Diseases and Glomerulopathies
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
Keywords
nephrotic syndrome, thyroid function, protein-bound iodine, hypothyroidism, hypometabolism, hypercholesterolemia, serum cholesterol
MeSH terms
Humans, Nephrosis, Thyroid Gland

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