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THE NORMAL LEVELS OF 17-HYDROXYCORTICOSTEROIDS IN THE PERIPHERAL BLOOD OF MAN 1
Open accessAbstract
Research in the field of adrenal cortical func- tion has been limited by the inability of existing techniques to measure precisely the kind and amounts of steroids elaborated by the gland.Particularly in man, the indicators have been indirect and inadequate.These have consisted principally of the alterations in certain non-steroid constitu- ents of the blood, changes in the total number of circulating lymphocytes and eosinophils, and vari- ations in end products of steroid metabolism found in the urine.Biological assays (1, 2) of the blood level of adrenal cortical hormones were developed with the hope that they would provide greater specific- ity, but have proved to be neither sufficiently sensitive nor precise.Chemical methods (3, 4, 5) for the determination of blood steroids have been proposed.The first satisfactory direct quantitative meas- urement of 17-hydroxycorticosteroids in the blood of human subjects was reported by Nelson and Samuels (6).This would include such "17-OH" compounds as E, F, and S, when present.Actually,
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Cited by
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DOE, R. P., VENNES, J. A., FLINK, E. B., ENGST, R., JOHNSON, P., & LEWIS, M. (1960) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-20-2-253 · Cited by 137
Masi, A. T., Josipovic, D. B., & Jefferson, W. E. (1984) · Seminars in Arthritis and Rheumatism · doi:10.1016/0049-0172(84)90005-2 · Cited by 85
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McClure, D. J. (1966) · Journal of Psychosomatic Research · doi:10.1016/0022-3999(66)90062-6 · Cited by 76
Metadata
- Authors
- Bliss, E. L., Sandberg, A. A., Nelson, D. H., & Eik-Nes, K.
- Venue
- Journal of Clinical Investigation
- Published
- 1953-09-01
- Volume
- 32
- Issue
- 9
- Pages
- 818-823
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W2025532284
- Cited by
- 168
- References
- 0
- FWCI
- 21.32
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: THE NORMAL LEVELS OF 17-HYDROXYCORTICOSTEROIDS IN THE PERIPHERAL BLOOD OF MAN 1. https://app.cochat.ai/papers/10.1172/jci102798
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- Bliss, E. L., Sandberg, A. A., Nelson, D. H., & Eik-Nes, K. (1953). THE NORMAL LEVELS OF 17-HYDROXYCORTICOSTEROIDS IN THE PERIPHERAL BLOOD OF MAN 1. Journal of Clinical Investigation. https://doi.org/10.1172/jci102798
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
