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THE EFFECT IN HUMANS OF EXTRACELLULAR pH CHANGE ON THE RELATIONSHIP BETWEEN SERUM POTASSIUM CONCENTRATION AND INTRACELLULAR POTASSIUM 1
Open accessAbstract
For many years investigators have been aware of the association of hyperkalemia with acidosis and hypokalemia with alkalosis.The early in vitro work of Fenn and Cobb (1) suggested that there might be a cause and effect relationship.However, it was not until recently that satisfac- tory in vivo data were obtained (2-7) which per- mitted the formulation of the hypothesis that changes in extracellular pH altered the extracel- lular potassium concentration independently of changes in total body potassium 3 (7).Thus, in animals, acidosis increases and alkalosis decreases the serum potassium concentration independently of changes in total body potassium.The present study demonstrates similar interrelationships in humans.
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Cited by
Dhatariya, K. K., Glaser, N. S., Codner, E., & Umpierrez, G. E. (2020) · Nature Reviews Disease Primers · doi:10.1038/s41572-020-0165-1 · Cited by 461
Changes in plasma potassium concentration during acute acid-base disturbances
Adrogué, H. J., & Madias, N. E. (1981) · The American Journal of Medicine · doi:10.1016/0002-9343(81)90182-0 · Cited by 388
Plasma potassium changes with high intensity exercise.
Medbø, J. I., & Sejersted, O. M. (1990) · The Journal of Physiology · doi:10.1113/jphysiol.1990.sp017935 · Cited by 275
Metadata
- Authors
- Burnell, J. M., Villamil, M. F., Uyeno, B. T., & Scribner, B. H.
- Venue
- Journal of Clinical Investigation
- Published
- 1956-09-01
- Volume
- 35
- Issue
- 9
- Pages
- 935-939
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W2068612764
- Cited by
- 276
- References
- 0
- FWCI
- 16.71
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: THE EFFECT IN HUMANS OF EXTRACELLULAR pH CHANGE ON THE RELATIONSHIP BETWEEN SERUM POTASSIUM CONCENTRATION AND INTRACELLULAR POTASSIUM 1. https://app.cochat.ai/papers/10.1172/jci103352
- The paper
- Burnell, J. M., Villamil, M. F., Uyeno, B. T., & Scribner, B. H. (1956). THE EFFECT IN HUMANS OF EXTRACELLULAR pH CHANGE ON THE RELATIONSHIP BETWEEN SERUM POTASSIUM CONCENTRATION AND INTRACELLULAR POTASSIUM 1. Journal of Clinical Investigation. https://doi.org/10.1172/jci103352
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
