THE PHYSIOLOGICAL MEANING OF THE MAXIMAL OXYGEN INTAKE TEST1
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Cardiac output is one of the key predictors of VO2max and determines the efficiency of oxygen transport to exercising musculature.
“Early physiological studies in humans demonstrated that one of the key predictors of an individual's VO 2 max is the blood flow generated by the heart, termed cardiac output (99), which determines the efficiency of oxygen transport to the exercising musculature.”
From The Hippo signal transduction network for exercise physiologists (2016) · cites this paper as [99]
The Discussion identifies cardiac output as a main circulatory determinant of maximal oxygen intake. But the Conclusions state that maximal oxygen intake depends on both cardiac output and the arteriovenous oxygen difference; the paper does not establish that cardiac output alone determines the efficiency of oxygen transport to exercising muscle. (LLM, conf=0.85)
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References 30 · Cited by 516
Research works printed but not linked: 4
- Dill, D. B., and F6lling, A. Studies in muscular ac- tivity. II. A nomographic description of expired air. J. Physiol. 1928, 66, 133.
- Robinson, S. Metabolic adaptations to exhausting work as affected by training (abstract). Amer. J. Physiol. 1941, 133, 428.
- Hickam, J. B., Pryor, W. W., Page, E. B., and At- well, R. J. Respiratory regulation during exer- cise in unconditioned subjects. J. clin. Invest. 1951, 30, 503.
- Dill, D. B. Life, Heat, and Altitude. Physiological Effects of Hot Climates and Great Heights. Cam- bridge, Harvard University Press, 1938, p. 13.
- Authors
- Mitchell, J. H., Sproule, B. J., & Chapman, C. B.
- Affiliations
- The University of Texas Southwestern Medical Center (US)
- Venue
- Journal of Clinical Investigation
- Published
- 1958-04-01
- Volume
- 37
- Issue
- 4
- Pages
- 538-547
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W1992941247
- Cited by
- 516
- References
- 30
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 7 · 2023: 10 · 2022: 5 · 2021: 9 · 2020: 13 · 2019: 11 · 2018: 7 · 2017: 6 · 2016: 4 · 2015: 6 · 2014: 11 · 2013: 7 · 2012: 9
- FWCI
- 25.66
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Clinical Investigation (publishedVersion)
- Funders
- U.S. Public Health Service
- Topics
- Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
- Health Sciences › Medicine › Surgery › Biomedical and Chemical Research
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Sports Performance and Training
- Keywords
- VO2max, oxygen consumption, cardiorespiratory fitness, exercise physiology
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