ALDOSTERONE SECRETION AND PRIMARY AND MALIGNANT HYPERTENSION *
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Activation of the renin-angiotensin axis plays an important role in the pathogenesis and pathophysiology of accelerated or malignant hypertension.
“The activation of the renin-angiotensin axis is known to play a very important role in the pathogenesis and pathophysiology of accelerated or malignant hypertension (7, 8).”
From Elevated sympathetic nerve activity in patients with accelerated essential hypertension. (1993) · cites this paper as [7]
The Summary reports elevated aldosterone secretion in 14 of 15 patients with malignant hypertension, supporting an association with the condition. The Discussion says aldosterone might contribute to the malignant syndrome but could also be a consequence of it. The paper does not establish activation of the renin–angiotensin axis or its important causal role (searched: renin, angiotensin, and pathogenesis). (LLM, conf=0.83)
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References 26 · Cited by 305
Research works printed but not linked: 28
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- Authors
- Laragh, J. H., Ulick, S., Januszewicz, V., Deming, Q. B., Kelly, W. G., & Lieberman, S.
- Affiliations
- Presbyterian Hospital (US)
- ORCID
- Kelly, William G.
- Venue
- Journal of Clinical Investigation
- Published
- 1960-07-01
- Volume
- 39
- Issue
- 7
- Pages
- 1091-1106
- ISSN
- 0021-9738 (ISSN-L)
- PMC
- PMC441854
- OpenAlex
- W2121832450
- Cited by
- 305
- References
- 26
- Citations by year
- 2024: 3 · 2022: 1 · 2017: 1 · 2016: 3 · 2015: 1 · 2014: 2 · 2013: 1 · 2012: 4
- FWCI
- 59.58
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Clinical Investigation (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- U.S. Public Health Service
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal Regulation and Hypertension
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Renin-Angiotensin System Studies
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
- Keywords
- aldosterone secretion, essential hypertension, malignant hypertension, renin-angiotensin system, aldosterone-producing adenoma
- MeSH terms
- Aldosterone, Biological Transport, Humans, Hypertension, Hypertension, Malignant, Lipid Metabolism
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