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STUDIES ON THE PATHOGENESIS OF THE ETHANOL-INDUCED FATTY LIVER. I. SYNTHESIS AND OXIDATION OF FATTY ACIDS BY THE LIVER*
Open accessAbstract
The present report is a study of changes in hepatic fatty acid synthesis and oxidation following ethanol administration in vivo and in vitro.Observations on the role of reduced and oxidized diphosphopyridine nucleotides are also presented.A subsequent report will deal with studies on lipid transport. MATERIALS AND METHODSPalmitate-1-C1' (specific activity 5 X 10' cpm per j.mole) was obtained from Volk Radiochemical Co., Chicago, Ill., and purified as described previously (8).Acetate- 1-C"' was purchased from New England Nuclear Corporation, Boston, Mass.Diphosphopyridine nucleotide (DPN) was obtained from Sigma Chemical Co., St. Louis, Mo.Hyamine-1OX was prepared according to the method of Passman, as modified by Eisenberg (9).Female albino rats (Charles River Laboratories, Boston, Mass.), weighing between 180 and 250 g and maintained on Purina Chow were used throughout this investigation.
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Citations
Cited by
Inhibition of hepatic gluconeogenesis by ethanol
Krebs, H. A., Freedland, R. A., Hems, R., & Stubbs, M. (1969) · Biochemical Journal · doi:10.1042/bj1120117 · Cited by 345
Alcohol effects on hepatic lipid metabolism
Jeon, S., & Carr, R. (2020) · Journal of Lipid Research · doi:10.1194/jlr.r119000547 · Cited by 326
The time-course of the effects of ethanol on the redox and phosphorylation states of rat liver
Veech, R. L., Guynn, R., & Veloso, D. (1972) · Biochemical Journal · doi:10.1042/bj1270387 · Cited by 257
Ethanol causes acute inhibition of carbohydrate, fat, and protein oxidation and insulin resistance.
Shelmet, J. J., Reichard, G. A., Skutches, C. L., Hoeldtke, R. D., Owen, O. E., & Boden, G. (1988) · Journal of Clinical Investigation · doi:10.1172/jci113428 · Cited by 199
Mechanism of ethanol induced hepatic injury
Lieber, C. S. (1990) · Pharmacology & Therapeutics · doi:10.1016/0163-7258(90)90032-w · Cited by 168
Metadata
- Authors
- Rebouças, G., & Isselbacher, K. J.
- Venue
- Journal of Clinical Investigation
- Published
- 1961-08-01
- Volume
- 40
- Issue
- 8 Pt 1-2
- Pages
- 1355-1362
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W1981196498
- Cited by
- 255
- References
- 0
- FWCI
- 23.23
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Rebouças, G., & Isselbacher, K. J. (1961). STUDIES ON THE PATHOGENESIS OF THE ETHANOL-INDUCED FATTY LIVER. I. SYNTHESIS AND OXIDATION OF FATTY ACIDS BY THE LIVER*. Journal of Clinical Investigation. https://doi.org/10.1172/jci104366
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
