The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Postnatal expression in hyaline cartilage of constitutively active human collagenase-3 (MMP-13) induces osteoarthritis in mice
Open accessAbstract
It has been suggested that increased collagenase-3 (MMP-13) activity plays a pivotal role in the pathogenesis of osteoarthritis (OA). We have used tetracycline-regulated transcription in conjunction with a cartilage-specific promoter to target a constitutively active human MMP-13 to the hyaline cartilages and joints of transgenic mice. Postnatal expression of this transgene resulted in pathological changes in articular cartilage of the mouse joints similar to those observed in human OA. These included characteristic erosion of the articular cartilage associated with loss of proteoglycan and excessive cleavage of type II collagen by collagenase, as well as synovial hyperplasia. These results demonstrate that excessive MMP-13 activity can result in articular cartilage degradation and joint pathology of the kind observed in OA, suggesting that excessive activity of this proteinase can lead to this disease.
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Cites
Tight control of gene expression in mammalian cells by tetracycline-responsive promoters.
Gossen, M., & Bujard, H. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.12.5547 · Cited by 4,943 · cited 4×
“The tTA gene, a 1,025-bp Eco RI/Bam HI fragment, was excised from pUHG15-1 (27) and cloned 3′ of the collagen promoter.”
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Cited by
Glasson, S. S., Chambers, M. G., Van Den Berg, W. B., & Little, C. B. (2010) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2010.05.025 · Cited by 1,708
Kraus, V. B., Huebner, J. L., DeGroot, J., & Bendele, A. (2010) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2010.04.015 · Cited by 1,771
Goldring, M. B., & Goldring, S. R. (2007) · Journal of Cellular Physiology · doi:10.1002/jcp.21258 · Cited by 1,179
Mechanisms and therapeutic implications of cellular senescence in osteoarthritis
Coryell, P. R., Diekman, B. O., & Loeser, R. F. (2021) · Nature Reviews Rheumatology · doi:10.1038/s41584-020-00533-7 · Cited by 761
Little, C. B., Barai, A., Burkhardt, D., Smith, S. M., Fosang, A. J., Werb, Z., Shah, M., & Thompson, E. W. (2009) · Arthritis & Rheumatism · doi:10.1002/art.25002 · Cited by 642
Metadata
- Authors
- Neuhold, L. A., Killar, L., Zhao, W., Sung, M.-L. A., Warner, L., Kulik, J., Turner, J., Wu, W., Billinghurst, C., Meijers, T., Poole, A. R., Babij, P., & DeGennaro, L. J.
- Venue
- Journal of Clinical Investigation
- Published
- 2001-01-01
- Volume
- 107
- Issue
- 1
- Pages
- 35-44
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W1967494982
- Cited by
- 540
- References
- 1
- FWCI
- 11.43
- Type
- journal article
- Language
- en
- Open access
- bronze
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- The paper
- Neuhold, L. A., Killar, L., Zhao, W., Sung, M.-L. A., Warner, L., Kulik, J., Turner, J., Wu, W., Billinghurst, C., Meijers, T., Poole, A. R., Babij, P., & DeGennaro, L. J. (2001). Postnatal expression in hyaline cartilage of constitutively active human collagenase-3 (MMP-13) induces osteoarthritis in mice. Journal of Clinical Investigation. https://doi.org/10.1172/jci10564
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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