The DOI matches its Crossref record.
Effect of altitude on oxygen binding by hemoglobin and on organic phosphate levels
Open accessAbstract
The relationship between oxygen dissociation and 2,3-diphosphoglycerate (2,3-DPG) in the red cell has been studied in subjects moving from low to high altitude and vice versa. Within 24 hr following the change in altitude there was a change in hemoglobin affinity for oxygen; this modification therefore represents an important rapid adaptive mechanism to anoxia. A parallel change occurred in the organic phosphate content of the red cell. While this study does not provide direct evidence of a cause-effect relationship, the data strongly suggest that with anoxia, the observed rise in organic phosphate content of the red cell is responsible for increased availability of oxygen to tissues.
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Citations
Cited by
Finch, C. A., & Lenfant, C. (1972) · New England Journal of Medicine · doi:10.1056/nejm197202242860806 · Cited by 319
Self-citationHemoglobin–oxygen affinity in high-altitude vertebrates: is there evidence for an adaptive trend?
Storz, J. F. (2016) · Journal of Experimental Biology · doi:10.1242/jeb.127134 · Cited by 136
Human llamas: adaptation to altitude in subjects with high hemoglobin oxygen affinity.
Hebbel, R. P., Eaton, J. W., Kronenberg, R. S., Zanjani, E. D., Moore, L. G., & Berger, E. M. (1978) · Journal of Clinical Investigation · doi:10.1172/jci109165 · Cited by 135
Effect of Smoking on Tissue Oxygen Supply
Sagone, A. L., Lawrence, T., & Balcerzak, S. P. (1973) · Blood · doi:10.1182/blood.v41.6.845.845 · Cited by 95
Phosphate Loading and the Effects on VO2max in Trained Cyclists
Stewart, I., McNaughton, L., Davies, P., & Tristram, S. (1990) · Research Quarterly for Exercise and Sport · doi:10.1080/02701367.1990.10607481 · Cited by 33
Metadata
- Authors
- Lenfant, C., Torrance, J., English, E., Finch, C. A., Reynafarje, C., Ramos, J., & Faura, J.
- Venue
- Journal of Clinical Investigation
- Published
- 1968-12-01
- Volume
- 47
- Issue
- 12
- Pages
- 2652-2656
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W2113974771
- Cited by
- 418
- References
- 0
- FWCI
- 41.08
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Lenfant, C., Torrance, J., English, E., Finch, C. A., Reynafarje, C., Ramos, J., & Faura, J. (1968). Effect of altitude on oxygen binding by hemoglobin and on organic phosphate levels. Journal of Clinical Investigation. https://doi.org/10.1172/jci105948
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
