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“Activation” of vitamin D by the liver
Open accessAbstract
Isolation of the liver from the circulation of rats eliminates almost completely their ability to convert [1,2]-(3)H vitamin D(3) into its biologically active metabolite, 25-hydroxycholecalciferol, as well as certain other metabolites. It is concluded that the liver is the major if not the only physiologic site of hydroxylation of vitamin D(3) (cholecalciferol) into 25-hydroxycholecalciferol. The osteodystrophy and the higher requirements for vitamin D observed in hepatic insufficiencies may be due to an inability of the liver to transform vitamin D into its metabolically active form.
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Citations
Cited by
The roles of vitamin D in skeletal muscle: form, function, and metabolism
Girgis, C. M., Clifton-Bligh, R. J., Hamrick, M. W., Holick, M. F., & Gunton, J. E. (2013) · Endocrine Reviews · doi:10.1210/er.2012-1012 · Cited by 567
Slominski, A. T., Kim, T., Shehabi, H. Z., Semak, I., Tang, E. K. Y., Nguyen, M. N., Benson, H. A. E., Korik, E., Janjetovic, Z., Chen, J., et al. (2012) · The FASEB Journal · doi:10.1096/fj.12-208975 · Cited by 266
History of the discovery of vitamin D and its active metabolites
DeLuca, H. F. (2014) · BoneKEy Reports · doi:10.1038/bonekey.2013.213 · Cited by 249
Self-citationVitamin D metabolism, sex hormones, and male reproductive function
Blomberg Jensen, M. (2012) · Reproduction · doi:10.1530/rep-12-0064 · Cited by 103
Obesity Represses CYP2R1 , the Vitamin D 25‐Hydroxylase, in the Liver and Extrahepatic Tissues
Elkhwanky, M., Kummu, O., Piltonen, T. T., Laru, J., Morin‐Papunen, L., Mutikainen, M., Tavi, P., & Hakkola, J. (2020) · JBMR Plus · doi:10.1002/jbm4.10397 · Cited by 80
Metadata
- Authors
- Ponchon, G., Kennan, A. L., & DeLuca, H. F.
- Venue
- Journal of Clinical Investigation
- Published
- 1969-11-01
- Volume
- 48
- Issue
- 11
- Pages
- 2032-2037
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W2073838768
- Cited by
- 388
- References
- 0
- FWCI
- 40.86
- Type
- journal article
- Language
- en
- Open access
- green
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- Ponchon, G., Kennan, A. L., & DeLuca, H. F. (1969). “Activation” of vitamin D by the liver. Journal of Clinical Investigation. https://doi.org/10.1172/jci106168
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
