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Cited by 141Thyroid Disorders and TreatmentsThyroid Cancer Diagnosis and TreatmentThyroid and Parathyroid Surgery

The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.

Inhibition by iodine of the release of thyroxine from the thyroid glands of patients with thyrotoxicosis

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Wartofsky, Leonard, Ransii, Bernard J., Ingbar, Sidney H.·1970·Journal of Clinical Investigation
DOI 10.1172/jci106225PMC PMC322446
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Abstract

A method has been devised which is free of many of the shortcomings of serial epithyroid counting techniques as an index of the rate of thyroid hormone secretion. By means of this method, the effect of treatment with Lugol's iodine on the rate of thyroidal secretion of thyroxine (T(4)) has been assessed in eight patients with thyrotoxicosis due to diffuse or multinodular goiter. The technique involves administration of a tracer dose of inorganic (125)I followed several days later by an intravenous tracer dose of (131)I-labeled T(4). Serial observations of serum protein-bound (PB) (125)I and (131)I are accompanied by frequent measurements of endogenous serum T(4) (T(4)-(127)I) concentration. Regardless of whether or not its administration was anteceded and accompanied by the administration of large doses of methimazole, iodine induced a rapid decrease in serum T(4)-(127)I concentration which could not be explained by an increase in the peripheral turnover of T(4), as judged from the metabolism of the (131)I-labeled hormone. Hence, the decreased serum T(4) concentration could only have resulted from decreased secretion of the hormone by the gland. Analyses of specific activity relationships between PB(125)I or T(4)-(127)I and PB(131)I made possible estimations of the extent to which iodine had decreased the rate of secretion of T(4). From such analysis, and in view of other considerations, it is concluded that the rapid decrease in T(4) secretion induced by iodine is not the result of an acute, sustained inhibition of T(4) synthesis, but rather results from an abrupt decrease in the fractional rate of thyroidal T(4) release.

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  1. Snedecor, G. W., and W. G. Cochran. 1967. Statistical Methods. Iowa State Univ. Press, Ames. 6th edition.

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Metadata

Authors
Wartofsky, L., Ransii, B. J., & Ingbar, S. H.
Affiliations
Harvard University (US)
ORCID
Wartofsky, Leonard
Venue
Journal of Clinical Investigation
Publisher
American Society for Clinical Investigation
Published
1970-01-01
Volume
49
Issue
1
Pages
78-86
ISSN
0021-9738 (ISSN-L)
DOI
10.1172/jci106225
PMC
PMC322446
OpenAlex
W2158995119
Cited by
141
References
17
Citations by year
2026: 6 · 2025: 3 · 2024: 5 · 2023: 2 · 2022: 5 · 2021: 2 · 2020: 3 · 2019: 4 · 2018: 3 · 2017: 4 · 2016: 3 · 2015: 3 · 2014: 7 · 2013: 3 · 2012: 2
FWCI
9.70
Type
journal article
Language
en
Open access
Locations
  • Journal of Clinical Investigation (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Cancer Diagnosis and Treatment
  • Health Sciences › Medicine › Surgery › Thyroid and Parathyroid Surgery
Keywords
thyrotoxicosis, thyroxine release, Lugol's iodine, thyroid hormone secretion, multinodular goiter, diffuse goiter, iodine-125 tracer, methimazole, serum thyroxine, protein-bound iodine, thyroid hormone synthesis
MeSH terms
Adult, Aged, Blood Proteins, Female, Goiter, Humans, Hyperthyroidism, Iodine, Iodine Radioisotopes, Male, Mathematics, Methimazole, Methods, Middle Aged, Protein Binding, Thyroid Gland, Thyroxine

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