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Effects of glucagon on adenosine 3′,5′-monophosphate and guanosine 3′,5′-monophosphate in human plasma and urine
Open accessAbstract
AB S TRA CT Glucagon, infused intravenously into fasting, well-hydrated, normal men in doses of 25-200 ng/kg per min, induced up to 30-fold increases in both plasma and urinary cyclic AMP.Cyclic GMP levels were unaffected by glucagon.Simultaneous cyclic AMP and inulin clearance studies demonstrated that the glucagoninduced increase in urinary cyclic AMP was entirely due to glomerular filtration of the elevated plasma levels of the nucleotide.The cyclic AMP response to glucagon was not medi- ated by parathyroid hormone or epinephrine, and trypsin- treated glucagon was completely inactive.The perfused rat liver released cyclic AMP into the perfusate in response to glucagon, indicating that the liver is a possible source of the cyclic AMP entering the extracellular fluids in response to glucagon in vivo.These studies were presented in part at the Annual Meeting of the Southern Society for Clinical Investigation, New Orleans, La., January 1969.Clin.Res.17: 65. (Abstr.).Dr. Broadus is a Fellow of the Life Insurance Medical Fund.
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Cited by
Radioimmunoassay for Cyclic Nucleotides
Steiner, A. L., Pagliara, A. S., Chase, L. R., & Kipnis, D. M. (1972) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)45622-6 · Cited by 572
Wang, M.-Y., Zhang, Z., Zhao, S., Onodera, T., Sun, X.-N., Zhu, Q., Li, C., Li, N., Chen, S., Paredes, M., et al. (2024) · Cell Metabolism · doi:10.1016/j.cmet.2023.12.024 · Cited by 52
Li, W., Kirchner, T., Ho, G., Bonilla, F., D'Aquino, K., Littrell, J., Zhang, R., Jian, W., Qiu, X., Zheng, S., et al. (2020) · Diabetes, Obesity and Metabolism · doi:10.1111/dom.14173 · Cited by 20
Metadata
- Authors
- Broadus, A. E., Kaminsky, N. I., Northcutt, R. C., Hardman, J. G., Sutherland, E. W., & Liddle, G. W.
- Venue
- Journal of Clinical Investigation
- Published
- 1970-12-01
- Volume
- 49
- Issue
- 12
- Pages
- 2237-2245
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W2073409252
- Cited by
- 191
- References
- 0
- FWCI
- 5.52
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Broadus, A. E., Kaminsky, N. I., Northcutt, R. C., Hardman, J. G., Sutherland, E. W., & Liddle, G. W. (1970). Effects of glucagon on adenosine 3′,5′-monophosphate and guanosine 3′,5′-monophosphate in human plasma and urine. Journal of Clinical Investigation. https://doi.org/10.1172/jci106442
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