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On the pathogenesis of hyperparathyroidism in chronic experimental renal insufficiency in the dog
Open accessAbstract
Healthy adult dogs were subjected to stepwise reduction of nephron population so as to create the transition from normal renal function to advanced renal insufficiency. Studies were performed at each level of renal function. Glomerular filtration rate (GFR), renal phosphate clearance, and serum radioimmunoassayable parathyroid hormone (PTH) levels were measured. Two groups of animals were studied. In one, phosphorous intake was maintained at 1200 mg/day. As GFR declined, fractional phosphate excretion rose reciprocally, and PTH levels increased over 20-fold. In the second group, phosphorous intake was maintained at less than 100 mg/day. As GFR fell, fractional phosphate excretion changed little, and no increment in PTH levels occurred. The data suggest that the control system regulating phosphate excretion contributes importantly to the pathogenesis of secondary hyperparathyroidism in advancing renal insufficiency.
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Cited by
Lavi-Moshayoff, V., Wasserman, G., Meir, T., Silver, J., & Naveh-Many, T. (2010) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00360.2010 · Cited by 441
Early Control of PTH and FGF23 in Normophosphatemic CKD Patients: A New Target in CKD-MBD Therapy?
Oliveira, R. B., Cancela, A. L. E., Graciolli, F. G., Dos Reis, L. M., Draibe, S. A., Cuppari, L., Carvalho, A. B., Jorgetti, V., Canziani, M. E., & Moysés, R. M. A. (2010) · Clinical Journal of the American Society of Nephrology · doi:10.2215/cjn.05420709 · Cited by 357
Mechanisms and Regulation of Intestinal Phosphate Absorption
Hernando, N., & Wagner, C. A. (2018) · Comprehensive Physiology · doi:10.1002/cphy.c170024 · Cited by 70
Phosphate intake, hyperphosphatemia, and kidney function
Rubio-Aliaga, I., & Krapf, R. (2022) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-022-02691-x · Cited by 65
Metadata
- Authors
- Slatopolsky, E., Caglar, S., Pennell, J. P., Taggart, D. D., Canterbury, J. M., Reiss, E., & Bricker, N. S.
- Venue
- Journal of Clinical Investigation
- Published
- 1971-03-01
- Volume
- 50
- Issue
- 3
- Pages
- 492-499
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W2089345381
- Cited by
- 481
- References
- 0
- FWCI
- 23.23
- Type
- journal article
- Language
- en
- Open access
- bronze
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- The paper
- Slatopolsky, E., Caglar, S., Pennell, J. P., Taggart, D. D., Canterbury, J. M., Reiss, E., & Bricker, N. S. (1971). On the pathogenesis of hyperparathyroidism in chronic experimental renal insufficiency in the dog. Journal of Clinical Investigation. https://doi.org/10.1172/jci106517
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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