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Effect of Free Fatty Acids on Myocardial Function and Oxygen Consumption in Intact Dogs
Open accessAbstract
Myocardial function and oxygen consumption (MVO(2)) were studied during increased myocardial uptake of free fatty acids (FFA) induced by intravenous infusion of a fat emulsion (Intralipid) after heparinization in anesthetized and intact dogs. During raised myocardial uptake of FFA, MVO(2) increased in all experiments. On the average, MVO(2) rose from 8.6 to 10.7 ml/min.100 g, or 26% (P < 0.001). This was mainly due to elevated myocardial oxygen extraction, as myocardial blood flow was unchanged, or increased slightly. In the recovery period, MVO(2) returned to normal. Left ventricular pressure, the maximal rate of rise of left ventricular pressure (dP/dt), heart rate, and cardiac output remained unchanged during the raised myocardial uptake of FFA. These experiments show that increased myocardial uptake of FFA in intact hearts was associated with augmented MVO(2), despite unchanged mechanical activity.
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Cited by
Beta blockade during and after myocardial infarction: An overview of the randomized trials
Yusuf, S., Peto, R., Lewis, J., Collins, R., & Sleight, P. (1985) · Progress in Cardiovascular Diseases · doi:10.1016/s0033-0620(85)80003-7 · Cited by 3,205
Capes, S. E., Hunt, D., Malmberg, K., & Gerstein, H. C. (2000) · The Lancet · doi:10.1016/s0140-6736(99)08415-9 · Cited by 2,187
Furnary, A. P., Gao, G., Grunkemeier, G. L., Wu, Y., Zerr, K. J., Bookin, S. O., Floten, H. S., & Starr, A. (2003) · The Journal of Thoracic and Cardiovascular Surgery · doi:10.1067/mtc.2003.181 · Cited by 1,130
Regulation of fatty acid oxidation in the mammalian heart in health and disease
Lopaschuk, G. D., Belke, D. D., Gamble, J., Toshiyuki, I., & Schönekess, B. O. (1994) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(94)00082-4 · Cited by 554
Effects of glucose and fatty acids on myocardial ischaemia and arrhythmias
Oliver, E. F., & Opie, L. H. (1994) · The Lancet · doi:10.1016/s0140-6736(94)90939-3 · Cited by 508
Metadata
- Authors
- Mjøs, O. D.
- Venue
- Journal of Clinical Investigation
- Published
- 1971-07-01
- Volume
- 50
- Issue
- 7
- Pages
- 1386-1389
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W2069689528
- Cited by
- 309
- References
- 0
- FWCI
- 11.26
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Mjøs, O. D. (1971). Effect of Free Fatty Acids on Myocardial Function and Oxygen Consumption in Intact Dogs. Journal of Clinical Investigation. https://doi.org/10.1172/jci106621
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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