Metabolic clearance rate and blood production rate of testosterone and dihydrotestosterone in normal subjects, during pregnancy, and in hyperthyroidism
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The metabolic clearance rate (MCR) and blood production rate (BP) of testosterone (T) and dihydrotestosterone (DHT), the conversion of plasma testosterone to plasma dihydrotestosterone, and the renal clearance of androstenedione, testosterone, and dihydrotestosterone have been studied in man. In eight normal men, the MCR(T) (516+/-108 [SD] liters/m(2)/day) was significantly greater than the MCR(DHT) (391+/-71 [SD] liters/m(2)/day). In seven females, the MCR(T) (304+/-53 [SD] liters/m(2)/day) was also greater than the MCR(DHT) (209+/-45 [SD] liters/m(2)/day) and both values were less than their respective values in men (P < 0.001). In men the conversion of testosterone into dihydrotestosterone at 2.8+/-0.3% (SD) was greater than that found in females, 1.56+/-0.5% (SD) (P < 0.001). In five pregnant females the MCR(T) (192+/-36 [SD] liters/m(2)/day), the MCR(DHT) (89+/-30 [SD] liters/m(2)/day) and the conversion of testosterone into dihydrotestosterone (0.72+/-0.15%) (SD) were significantly less than the values found in nonpregnant women. In five females with hyperthyroidism, the MCR for testosterone and dihydrotestosterone were similar to those observed in pregnant females, but the conversion of testosterone into dihydrotestosterone (2.78+/-1.7%) (SD) was greater, and similar to that found in men. In men the production of dihydrotestosterone was 0.39+/-0.1 (SD) mg/day, 50% being derived from the transformation of plasma testosterone. In women the production of DHT was 0.05+/-0.028 (SD) mg/day, only 10% coming from testosterone. During pregnancy, the production of testosterone and dihydrotestosterone are similar to that in normal women. In three patients with testicular feminization syndrome (an adult with hyperthyroidism and two children) these two MCRs were greatly reduced compared to the normal females, but the conversion of testosterone into dihydrotestosterone was in the limits of normal male rangeIn the normal subjects the renal clearance of androstenedione was greater than that of testosterone and dihydrotestosterone. Less than 20% of the dihydrotestosterone and less than 10% of the androstenedione in the urine is derived from the plasma dihydrotestosterone and androstenedione.
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Circulating testosterone in men is 15-fold higher than in children or women of any age.
“circulating testosterone exceeding 15-fold that of women at any age”
From Circulating Testosterone as the Hormonal Basis of Sex Differences in Athletic Performance (2018) · cites this paper as [7]
After puberty, men produce 20 times more testosterone than women.
“after puberty men produce 20 times more testosterone than women (4–7)”
From Circulating Testosterone as the Hormonal Basis of Sex Differences in Athletic Performance (2018) · cites this paper as [7]
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References 34 · Cited by 91
- Authors
- Saez, J. M., Forest, M. G., Morera, A. M., & Bertrand, J.
- Affiliations
- Inserm (FR)
- Venue
- Journal of Clinical Investigation
- Published
- 1972-05-01
- Volume
- 51
- Issue
- 5
- Pages
- 1226-1234
- ISSN
- 0021-9738 (ISSN-L)
- PMC
- PMC292254
- OpenAlex
- W2015813771
- Cited by
- 91
- References
- 34
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 3 · 2023: 4 · 2022: 1 · 2020: 1 · 2019: 1 · 2018: 3 · 2017: 1 · 2016: 2 · 2015: 1 · 2014: 1 · 2012: 2
- FWCI
- 4.07
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Clinical Investigation (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Keywords
- testosterone, dihydrotestosterone, metabolic clearance rate, androgen metabolism, 5α-reductase, pregnancy, hyperthyroidism, androgen insensitivity syndrome, androstenedione, renal clearance, sex differences, androgen production, 5β-dihydrotestosterone, 5beta-reductase
- MeSH terms
- Adult, Androstanes, Carbon Isotopes, Child, Preschool, Chromatography, Gas, Chromatography, Thin Layer, Female, Humans, Hyperthyroidism, Infant, Ketosteroids, Kidney, Male, Metabolic Clearance Rate, Middle Aged, Pregnancy, Protein Binding, Dihydrotestosterone, Androgen-Insensitivity Syndrome, Testosterone, Tritium, 17-Ketosteroids
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