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Cited by 428Renin-Angiotensin System StudiesRenal Diseases and GlomerulopathiesRenal and Vascular Pathologies

The DOI matches its Crossref record; 46 of the 48 references it cites were found in a registry or an index.

Angiotensin II effects upon the glomerular microcirculation and ultrafiltration coefficient of the rat.

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Blantz, R C, Konnen, K S, Tucker, B J·1976·Journal of Clinical Investigation
DOI 10.1172/jci108293PMC PMC436666
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Abstract

The effects of both synthetic and biologically produced angiotensin II (AII) upon the process of glolerular filtration were examined in the plasma-expanded (2.5% body wt) Munich-Wistar rat, by micropuncture evaluation of pressures, nephron plasma flow (rpf) and filtration rate (sngfr). Plasma expansion was chosen as a control condition because (a) response to AII was uniform and predictable, (b) endogenous generation of AII was presumably suppressed, and (c) the high control values for rpf permitted accurate determination of values for the glomerular permeability coefficient (LpA) before and during AII infusion. With subpressor quantities of synthetic Asn-1, Val-5 AII (less than 5 ng/100 g body wt/min), sngfr fell from 47.7 in the control group to 39.8 nl/min/g kidney (P less than 0.005). The rpf fell to 60% of control values (P less than 0.001). Measurement of glomerular capillary (PG) and Bowman's space (Pt) hydrostatic pressures in surface glomeruli with a servo-nulling device permitted evaluation of the hydrostatic pressure gradient (deltaP = PG - Pi). DeltaP increased from 38.1 +/- 1.2 in control to 45.9 +/- 1.3 mm Hg after Asn-1, Val-5 AII and essentially neutralized the effect of decreased rpf in sngfr. The sngfr then fell as a result of a decreased in LpA from 0.063 +/- 0.008 in control to 0.028 +/- 0.004 nl/s/g kidney/mm Hg after Asn-1, Val-5 AII (P less than 0.02). Lower doses of Asp-1, Ile-5 AII (less than 3 ng/100 g body wt/min) had no effect on sngfr, rpf, deltaP, and afferent and efferent vascular resistance, but significantly elevated systemic blood pressure, suggesting peripheral effects on smooth muscle at this low dose. LpA was 0.044 +/- 0.007 nl/s/g kidney/mm Hg after low-dose Asp-1, Ile-5 AII, and 0.063 +/- 0.008 in the control group (0.02 greater than P greater than 0.1). Higher, equally pressor doses of native AII (5 ng/100 g body wt/min) produced effects almost identical to similar quantites of synthetic Asn-1, Val-5 AII upon rpf, deltaP, sngfr, and renal vascular resistance. LpA again fell to 0.026 +/- 0.004 nl/s/g kidney/mn Hg, a value almost identical to that after the synthetic AII. Paired studies with Asp-1, Ile-5 AII also demonstrated a consistent reduction in LpA.

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Crossref · 10.1172/jci108293

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Metadata

Authors
Blantz, R. C., Konnen, K. S., & Tucker, B. J.
Affiliations
United States Department of Veterans Affairs (US)
Venue
Journal of Clinical Investigation
Publisher
American Society for Clinical Investigation
Published
1976-02-01
Volume
57
Issue
2
Pages
419-434
ISSN
0021-9738 (ISSN-L)
DOI
10.1172/jci108293
PMC
PMC436666
OpenAlex
W2144447462
Cited by
428
References
48
Citations by year
2026: 3 · 2025: 3 · 2023: 1 · 2022: 2 · 2021: 4 · 2020: 4 · 2019: 1 · 2018: 1 · 2017: 1 · 2015: 2 · 2014: 2 · 2013: 2 · 2012: 13
FWCI
11.58
Type
journal article
Language
en
Open access
Locations
  • Journal of Clinical Investigation (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Cleveland Clinic
  • National Institutes of Health
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Renin-Angiotensin System Studies
  • Health Sciences › Medicine › Nephrology › Renal Diseases and Glomerulopathies
  • Health Sciences › Medicine › Nephrology › Renal and Vascular Pathologies
Keywords
angiotensin II, glomerular filtration, glomerular microcirculation, plasma flow, hydrostatic pressure gradient, plasma expansion, systemic blood pressure, dose-response relationship, rat kidney
MeSH terms
Angiotensin II, Animals, Blood Pressure, Blood Volume, Capillary Permeability, Glomerular Filtration Rate, Hydrostatic Pressure, Kidney Glomerulus, Kidney Tubules, Proximal, Male, Microcirculation, Nephrons, Vascular Resistance, Rats

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