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Inhibition of platelet prostaglandin synthetase by oral aspirin.
Open accessAbstract
Aspirin inhibits platelet function by permanently acetylating the cyclooxygenase that forms prostaglandins. We determined the sensitivity of platelets to aspirin in normal subjects by measuring [3H-acetyl]aspirin-susceptible cyclooxygenase in washed platelets obtained at various times after aspirin ingestion. A single 325-mg aspirin dose inactivated 89% of platelet cyclooxygenase. The inhibition persisted for 2 days suggesting that oral aspirin also inactivated megakaryocyte cyclooxygenase. Thereafter, active enzyme returned with a time-course reflecting platelet turnover (life-span 8.2+/-2 days). Single doses of 20-650 mg aspirin resulted in 34- greater than 95% inhibition after 24 h. Daily doses of 20-325 mg aspirin for brief periods produced 61- greater than 95% inactivation when measured 24 h after cessation of the drug. Platelet cyclooxygenase is more sensitive to inactivation by aspirin than enzyme in sheep seminal vesicles.
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Cited by
Patrono, C., Coller, B., Dalen, J. E., Fitz Gerald, G. A., Fuster, V., Gent, M., Hirsh, J., & Roth, G. (2001) · Chest · doi:10.1378/chest.119.1_suppl.39s · Cited by 963
Patrignani, P., Filabozzi, P., & Patrono, C. (1982) · Journal of Clinical Investigation · doi:10.1172/jci110576 · Cited by 937
Thromboxane Biosynthesis and Platelet Function in Type II Diabetes Mellitus
Davì, G., Catalano, I., Averna, M., Notarbartolo, A., Strano, A., Ciabattoni, G., & Patrono, C. (1990) · New England Journal of Medicine · doi:10.1056/nejm199006213222503 · Cited by 597
Weitz, J. I., Eikelboom, J. W., & Samama, M. M. (2012) · Chest · doi:10.1378/chest.11-2294 · Cited by 527
Clinical pharmacology of platelet cyclooxygenase inhibition.
Patrono, C., Ciabattoni, G., Patrignani, P., Pugliese, F., Filabozzi, P., Catella, F., Davì, G., & Forni, L. (1985) · Circulation · doi:10.1161/01.cir.72.6.1177 · Cited by 454
Metadata
- Authors
- Burch, J. W., Stanford, N., & Majerus, P. W.
- Venue
- Journal of Clinical Investigation
- Published
- 1978-02-01
- Volume
- 61
- Issue
- 2
- Pages
- 314-319
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W2162637702
- Cited by
- 558
- References
- 0
- FWCI
- 37.97
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Inhibition of platelet prostaglandin synthetase by oral aspirin. https://app.cochat.ai/papers/10.1172/jci108941
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- Burch, J. W., Stanford, N., & Majerus, P. W. (1978). Inhibition of platelet prostaglandin synthetase by oral aspirin. Journal of Clinical Investigation. https://doi.org/10.1172/jci108941
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
