The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Experimental glomerulonephritis in the isolated perfused rat kidney.
Open accessAbstract
The development of immune deposits on the subepithelial surface of the glomerular capillary wall was studied in isolated rat kidneys perfused at controlled perfusion pressure, pH, temperature, and flow rates with recirculating oxygenated perfusate containing bovine serum albumin (BSA) in buffer and sheep antibody to rat proximal tubular epithelial cell brush border antigen (Fx1A). Control kidney were perfused with equal concentrations of non-antibody immunoglobulin (Ig)G. Renal function was monitored by measuring inulin clearance, sodium reabsorption, and urine flow as well as BSA excretion and fractional clearance. Perfused kidneys were studied by light, immunofluorescence, and electron microscopy. All kidneys perfused with anti-Fx1A developed diffuse, finely granular deposits of IgG along the glomerular capillary wall by immunofluorescence. Electron microscopy revealed these deposits to be localized exclusively in the subepithelial space and slit pores. Similar deposits were produced in a nonrecirculating perfusion system, thereby excluding the formation of immune complexes in the perfusate caused by renal release of tubular antigen. Control kidneys perfused with nonantibody IgG did not develop glomerular immune deposits. Renal function and BSA excretion were the same in experimental and control kidneys. Glomerular deposits in antibody perfused kidneys were indistinguishable from deposits in rats injected with anti-Fx1A or immunized with Fx1A to produce autologous immune complex nephropathy. These studies demonstrate that subepithelial immune deposits can be produced in the isolated rat kidney by perfusion with specific antibody to Fx1A in the absence of circulating immune complexes. In this model deposits result from in situ complex formation rather than circulating immune complex deposition.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Izui, S., Lambert, P. H., & Miescher, P. A. (1976) · The Journal of experimental medicine · doi:10.1084/jem.144.2.428 · Cited by 313
Cited by
M-Type Phospholipase A 2 Receptor as Target Antigen in Idiopathic Membranous Nephropathy
Beck, L. H., Bonegio, R. G. B., Lambeau, G., Beck, D. M., Powell, D. W., Cummins, T. D., Klein, J. B., & Salant, D. J. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0810457 · Cited by 2,347
Self-citationIn situ immune complex formation and glomerular injury
Couser, W. G., & Salant, D. J. (1980) · Kidney International · doi:10.1038/ki.1980.1 · Cited by 379
Self-citationA new role for complement in experimental membranous nephropathy in rats.
Salant, D. J., Belok, S., Madaio, M. P., & Couser, W. G. (1980) · Journal of Clinical Investigation · doi:10.1172/jci109987 · Cited by 310
Self-citation
Metadata
- Authors
- Couser, W. G., Steinmuller, D. R., Stilmant, M. M., Salant, D. J., & Lowenstein, L. M.
- Venue
- Journal of Clinical Investigation
- Published
- 1978-12-01
- Volume
- 62
- Issue
- 6
- Pages
- 1275-1287
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W2134252312
- Cited by
- 385
- References
- 1
- FWCI
- 18.43
- Type
- journal article
- Language
- en
- Open access
- bronze
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Experimental glomerulonephritis in the isolated perfused rat kidney. https://app.cochat.ai/papers/10.1172/jci109248
- The paper
- Couser, W. G., Steinmuller, D. R., Stilmant, M. M., Salant, D. J., & Lowenstein, L. M. (1978). Experimental glomerulonephritis in the isolated perfused rat kidney. Journal of Clinical Investigation. https://doi.org/10.1172/jci109248
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
