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Comparison of spontaneous and experimentally induced canine prostatic hyperplasia.
Open accessAbstract
Spontaneous prostatic hyperplasia in the beagle appears to progress with age from a glandular to a cystic histological appearance. Prostatic hyperplasia can be induced in young beagles with intact testes by treatment for 4 mo with either dihydrotestosterone or 5 alpha-androstane-3 alpha, 17 beta-diol, alone, or with either of these steroids in combination with 17 beta-estradiol. In contrast, the induction of prostatic hyperplasia in young castrated beagles, in which the gland had been allowed to involute for 1 mo, requires the administration of both 17 beta-estradiol and either 5 alpha-androstane-3 alpha, 17 beta-diol or dihydrotestosterone. Testosterone and 17 beta-estradiol, either singly or in combination, did not produce the hyperplastic condition in intact or castrated beagles. The experimentally induced prostatic hyperplasia is identical in pathology to the glandular hyperplasia that occurs naturally in the aging dog with intact testes. However, cystic hyperplasia was not produced by any of the treatments tested in young animals.
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Cited by
Hayward, S. W., Dahiya, R., Cunha, G. R., Bartek, J., Deshpande, N., & Narayan, P. (1995) · In Vitro Cellular & Developmental Biology - Animal · doi:10.1007/bf02631333 · Cited by 340
The role of estrogens and estrogen receptors in normal prostate growth and disease
Prins, G. S., & Korach, K. S. (2008) · Steroids · doi:10.1016/j.steroids.2007.10.013 · Cited by 332
Bauman, D. R., Steckelbroeck, S., Williams, M. V., Peehl, D. M., & Penning, T. M. (2006) · Molecular Endocrinology · doi:10.1210/me.2005-0287 · Cited by 120
Metadata
- Authors
- DeKlerk, D. P., Coffey, D. S., Ewing, L. L., McDermott, I. R., Reiner, W. G., Robinson, C. H., Scott, W. W., Strandberg, J. D., Talalay, P., Walsh, P. C., Wheaton, L. G., & Zirkin, B. R.
- Venue
- Journal of Clinical Investigation
- Published
- 1979-09-01
- Volume
- 64
- Issue
- 3
- Pages
- 842-849
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W1993285058
- Cited by
- 283
- References
- 0
- FWCI
- 19.41
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Comparison of spontaneous and experimentally induced canine prostatic hyperplasia. https://app.cochat.ai/papers/10.1172/jci109532
- The paper
- DeKlerk, D. P., Coffey, D. S., Ewing, L. L., McDermott, I. R., Reiner, W. G., Robinson, C. H., Scott, W. W., Strandberg, J. D., Talalay, P., Walsh, P. C., Wheaton, L. G., & Zirkin, B. R. (1979). Comparison of spontaneous and experimentally induced canine prostatic hyperplasia. Journal of Clinical Investigation. https://doi.org/10.1172/jci109532
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