The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.
Biphasic Adrenergic Modulation of β-Adrenergic Receptors in Man
Abstract
beta-Adrenergic receptors in mononuclear leukocyte preparations were assessed with (-)[(3)H]-dihydroalprenolol binding studies during the infusion of adrenergic agonists into normal human subjects. During the infusion of isoproterenol into seven subjects, mean (+/-SE) (-)[(3)H]dihydroalprenolol binding increased from 25+/-3 fmol/mg protein to 47+/-8 fmol/mg protein (P < 0.02) at 0.5 h and 40+/-3 fmol/mg protein (P < 0.01) at 1 h and decreased to 12+/-1 fmol/mg protein (P < 0.01) at 4-6 h. During the infusion of epinephrine into three subjects, mean (-)[(3)H]dihydroalprenolol binding increased from 32+/-3 to 63+/-3 fmol/mg protein (P < 0.01) at 0.5-1 h. By Scatchard plot analysis, these changes were attributable to changes in the number of available binding sites rather than changes in binding affinity. The observed changes in the number of (-)[(3)H]dihydroalprenolol binding sites were not paralleled by changes in total mononuclear cell counts or in T lymphocyte, B lymphocyte, and monocyte distributions. Thus, we conclude that adrenergic agonists modulate the number of available beta-adrenergic receptors on circulating mononuclear cells in a biphasic manner, with an early increment and a late decrement, in man. Further, the finding that the increase in pulse rate in response to a "pulse" infusion of isoproterenol was significantly greater after 0.5-1 h of agonist infusion suggests that the observed early agonist-induced increment in beta-adrenergic receptor number on circulating cells is paralleled by increments in extra-vascular beta-adrenergic receptor sensitivity.
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“This preparation contains (−)[³H]DHA binding sites that exhibit the characteristics of β-adrenergic receptors, in that binding is rapid, reversible, and saturable, and in that competition for binding by agonists (and other antagonists) is stereospecific and exhibits the potency sequence isoproterenol > epinephrine > norepinephrine.”
From Triiodothyronine-induced Thyrotoxicosis Increases Mononuclear Leukocyte β-Adrenergic Receptor Density in Man (1981) · cites this paper as [32]
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Cites
PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT
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Self-citationMembrane receptors for hormones and neurotransmitters.
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Phospholipid Methylation Unmasks Cryptic β-Adrenergic Receptors in Rat Reticulocytes
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Induction of a Lactogenic Receptor in Rat Liver: Influence of Estrogen and the Pituitary
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Self-citationIn Vitro Study of beta-Adrenergic Receptors
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Binding of [3H]dihydroazapetine to alpha-adrenoreceptor-related proteins from rat vas deferens.
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Human B-cell mitogenic responsiveness to lectins: The requirement for T cells
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Cited by
Autonomic imbalance hypothesis and overtraining syndrome
LEHMANN, M., FOSTER, C., DICKHUTH, H.-H., & GASTMANN, U. (1998) · Medicine & Science in Sports & Exercise · doi:10.1097/00005768-199807000-00019 · Cited by 221
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Metadata
- Authors
- Tohmeh, J. F., & Cryer, P. E.
- Venue
- Journal of Clinical Investigation
- Published
- 1980-04-01
- Volume
- 65
- Issue
- 4
- Pages
- 836-840
- ISSN
- 0021-9738
- Cited by
- 113
- References
- 20
- Language
- en
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Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
