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New biochemical marker for bone metabolism. Measurement by radioimmunoassay of bone GLA protein in the plasma of normal subjects and patients with bone disease.
Open accessAbstract
gamma-Carboxyglutamic acid-containing protein of bone (BGP) is an abundant noncollagenous protein of mammalian bone. BGP has a molecular weight of 5,800 and contains three residues of the vitamin K-dependent amino acid, gamma-carboxyglutamic acid. We have applied a radioimmunoassay based on calf BGP for the measurement of the protein in the plasma of 109 normal humans and 112 patients with various bone diseases. BGP in human plasma was demonstrated to be indistinguishable from calf BGP by assay dilution studies and gel permeation chromatography. The mean (+/- SE) concentration of BGP in normal subjects was 6.78 (+/- 0.20) ng/ml, 7.89 (+/- 0.32) for males and 4.85 (+/- 0.35) for females. Plasma BGP was increased in patients with Paget's disease of bone, bone metastases, primary hyperparathyroidism, renal osteodystrophy, and osteopenia. Plasma BGP did correlate with plasma alkaline phosphatase (AP) in some instances, but there were dissociations between the two. It was additionally observed that patients with liver disease had normal plasma BGP despite increased plasma AP, a reflection of the lack of specificity of AP measurements for bone disease. Our studies indicate that the radioimmunoassay of plasma BGP can be a useful and specific procedure for evaluating the patient with bone disease.
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Citations
Cited by
SERUM BONE GLA-PROTEIN: A SPECIFIC MARKER FOR BONE FORMATION IN POSTMENOPAUSAL OSTEOPOROSIS
Brown, J. P., Malaval, L., Chapuy, M. C., Delmas, P. D., Edouard, C., & Meunier, P. J. (1984) · The Lancet · doi:10.1016/s0140-6736(84)92506-6 · Cited by 668
Morrison, N. A., Yeoman, R., Kelly, P. J., & Eisman, J. A. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.15.6665 · Cited by 601
Osteocalcin: Isolation, characterization, and detection
Gundberg, C. M., Hauschka, P. V., Lian, J. B., & Gallop, P. M. (1984) · Methods in Enzymology · doi:10.1016/0076-6879(84)07036-1 · Cited by 332
Sartorio, A., Conti, A., Ferrero, S., Giambona, S., Re, T., Passini, E., & Ambrosi, B. (1998) · European Journal of Endocrinology · doi:10.1530/eje.0.1380146 · Cited by 84
Differences in basal and postexercise osteocalcin levels in athletic and nonathletic humans
Nishiyama, S., Tomoeda, S., Ohta, T., Higuchi, A., & Matsuda, I. (1988) · Calcified Tissue International · doi:10.1007/bf02571312 · Cited by 86
Metadata
- Authors
- Price, P. A., Parthemore, J. G., & Deftos, L. J.
- Venue
- Journal of Clinical Investigation
- Published
- 1980-11-01
- Volume
- 66
- Issue
- 5
- Pages
- 878-883
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W2041633275
- Cited by
- 657
- References
- 0
- FWCI
- 27.27
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Price, P. A., Parthemore, J. G., & Deftos, L. J. (1980). New biochemical marker for bone metabolism. Measurement by radioimmunoassay of bone GLA protein in the plasma of normal subjects and patients with bone disease. Journal of Clinical Investigation. https://doi.org/10.1172/jci109954
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
