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Cyclosporin a. Inhibition of experimental autoimmune uveitis in Lewis rats.
Open accessAbstract
Cyclosporin A (CS-A), a selective inhibitor of T lymphocytes, is reported here to prevent S antigen (S-Ag) induced uveitis in Lewis rats. The S-Ag, found in all mammalian retinas, is uveitogenic under experimental conditions and patients with certain uveitic entities demonstrate cell mediated responses to this antigen. Daily treatment with CS-A (10 mg/kg) begun on the same day as S-Ag immunization totally inhibited the development of the uveitis in this experimental autoimmune model. Moreover a greater CS-A dose (40 mg/kg) efficiently prevented the disease process when therapy was started 7 d after S-Ag immunization. Anti-S-Ag antibody titers were observed to be similar in rats either protected or not protected with CS-A. Our data support strongly the need for T cell participation in this disease model. Since ocular inflammatory disease is an important cause of visual impairment, the data further suggest that CS-A may be useful in the treatment of patients with intractable uveitis.
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Cited by
Masuda, K., Urayama, A., Kogure, M., Nakajima, A., Nakae, K., & Inaba, G. (1989) · The Lancet · doi:10.1016/s0140-6736(89)92381-7 · Cited by 490
Nussenblatt, R. B., Mittal, K. K., Ryan, S., Richard Green, W., & Edward Maumenee, A. (1982) · American Journal of Ophthalmology · doi:10.1016/0002-9394(82)90069-1 · Cited by 351
Self-citationKodama, M., Matsumoto, Y., Fujiwara, M., Masani, F., Izumi, T., & Shibata, A. (1990) · Clinical Immunology and Immunopathology · doi:10.1016/0090-1229(90)90039-s · Cited by 330
Nussenblatt, R. B., Palestine, A. G., & Chan, C.-C. (1983) · American Journal of Ophthalmology · doi:10.1016/s0002-9394(14)77814-6 · Cited by 323
Self-citationChapter 3 Retinal specific antigens and immunopathogenic processes they provoke
Gery, I., Mochizuki, M., & Nussenblatt, R. B. (1986) · Progress in Retinal Research · doi:10.1016/0278-4327(86)90006-4 · Cited by 280
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Metadata
- Authors
- Nussenblatt, R. B., Rodrigues, M. M., Wacker, W. B., Cevario, S. J., Salinas-Carmona, M. C., & Gery, I.
- Venue
- Journal of Clinical Investigation
- Published
- 1981-04-01
- Volume
- 67
- Issue
- 4
- Pages
- 1228-1231
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W2029595835
- Cited by
- 170
- References
- 0
- FWCI
- 9.54
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Nussenblatt, R. B., Rodrigues, M. M., Wacker, W. B., Cevario, S. J., Salinas-Carmona, M. C., & Gery, I. (1981). Cyclosporin a. Inhibition of experimental autoimmune uveitis in Lewis rats. Journal of Clinical Investigation. https://doi.org/10.1172/jci110138
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