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Sulfasalazine inhibits the synthesis of chemotactic lipids by neutrophils.
Open accessAbstract
Neutrophils metabolize arachidonic acid through the liposygenase pathway to 5-hydroxy-6,8,11,14-eicosatetrenoic acid (5-HETE) and 5,12-dihydroxy-6,8,10,14-eicosatraenoic acid (5,12 diHETE). 5-HETE and 5,12diHETE are potent chemotactic agents and are thought to have important roles in the inflammatory response. In this study we demonstrate the sulfasalazine, at concentrations found in the stool of patients being treated for ulcerative colitis, blocks the synthesis of both 5-HETE and 5,12 diHETE by human neutrophils. A sulfasalazine metabolite, 5-aminosalicylate, also blocks the synthesis of 5,12 diHETE.
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Cited by
Enhanced synthesis of leukotriene B4 by colonic mucosa in inflammatory bowel disease
Sharon, P., & Stenson, W. F. (1984) · Gastroenterology · doi:10.1016/s0016-5085(84)80015-3 · Cited by 738
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Metadata
- Authors
- Stenson, W. F., & Lobos, E.
- Venue
- Journal of Clinical Investigation
- Published
- 1982-02-01
- Volume
- 69
- Issue
- 2
- Pages
- 494-497
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W1999197985
- Cited by
- 229
- References
- 0
- FWCI
- 11.68
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Stenson, W. F., & Lobos, E. (1982). Sulfasalazine inhibits the synthesis of chemotactic lipids by neutrophils. Journal of Clinical Investigation. https://doi.org/10.1172/jci110474
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
