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Chemotaxis of monocytes and neutrophils to platelet-derived growth factor.
Open accessAbstract
The platelet-derived growth factor (PDGF) is shown to be chemotactic for monocytes and neutrophils. Maximum monocyte chemotaxis to PDGF is fully equal to that achieved with C5a and occurs at congruent to 20 ng/ml (congruent to 0.7 nM). Maximum neutrophil chemotaxis is congruent to 60% that achieved with C5A but occurs at congruent to 1 ng/ml (congruent to 32 pM). The chemotactic activity of PDGF is blocked by specific antisera to PDGF and by protamine sulfate, a competitive inhibitor of PDGF binding to cell surfaces. In contrast to PDGF, epidermal growth factor shows no chemotactic activity for inflammatory cells at 0.5-100 ng/ml. The high level of chemotactic activity of PDGF suggests that in addition to its role as a mitogen for smooth muscle cells and fibroblasts, PDGF may be involved in attracting inflammatory cells to sites of platelet release.
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Citations
Cited by
Recombinant Human Platelet-Derived Growth Factor: Biology and Clinical Applications
Hollinger, J. O., Hart, C. E., Hirsch, S. N., Lynch, S., & Friedlaender, G. E. (2008) · Journal of Bone and Joint Surgery · doi:10.2106/jbjs.g.01231 · Cited by 353
Grotendorst, G. R., Martin, G. R., Pencev, D., Sodek, J., & Harvey, A. K. (1985) · Journal of Clinical Investigation · doi:10.1172/jci112243 · Cited by 275
Mustoe, T. A., Pierce, G. F., Morishima, C., & Deuel, T. F. (1991) · Journal of Clinical Investigation · doi:10.1172/jci115048 · Cited by 266
Self-citationCarré, P. C., Mortenson, R. L., King, T. E., Noble, P. W., Sable, C. L., & Riches, D. W. (1991) · Journal of Clinical Investigation · doi:10.1172/jci115501 · Cited by 253
Clark, R. A., Wikner, N. E., Doherty, D. E., & Norris, D. A. (1988) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)37900-6 · Cited by 152
Metadata
- Authors
- Deuel, T. F., Senior, R. M., Huang, J. S., & Griffin, G. L.
- Venue
- Journal of Clinical Investigation
- Published
- 1982-04-01
- Volume
- 69
- Issue
- 4
- Pages
- 1046-1049
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W1977070858
- Cited by
- 549
- References
- 0
- FWCI
- 15.81
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Chemotaxis of monocytes and neutrophils to platelet-derived growth factor. https://app.cochat.ai/papers/10.1172/jci110509
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- Deuel, T. F., Senior, R. M., Huang, J. S., & Griffin, G. L. (1982). Chemotaxis of monocytes and neutrophils to platelet-derived growth factor. Journal of Clinical Investigation. https://doi.org/10.1172/jci110509
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
