Cited by 483Pancreatic function and diabetesDiabetes and associated disordersDiabetes Treatment and Management

The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.

Diminished B cell secretory capacity in patients with noninsulin-dependent diabetes mellitus

Open access

Ward, W K, Bolgiano, D C, McKnight, B, Halter, J B, Porte, D·1984·Journal of Clinical Investigation

Open this paper in CoChat — free account Open PDF

Abstract

In order to assess whether patients with noninsulin-dependent diabetes mellitus (NIDDM) possess normal insulin secretory capacity, maximal B cell responsiveness to the potentiating effects of glucose was estimated in eight untreated patients with NIDDM and in eight nondiabetic controls. The acute insulin response to 5 g intravenous arginine was measured at five matched plasma glucose levels that ranged from approximately 100-615 mg/dl. The upper asymptote approached by acute insulin responses (AIRmax) and the plasma glucose concentration at half-maximal responsiveness (PG50) were estimated using nonlinear regression to fit a modification of the Michaelis-Menten equation. In addition, glucagon responses to arginine were measured at these same glucose levels to compare maximal A cell suppression by hyperglycemia in diabetics and controls. Insulin responses to arginine were lower in diabetics than in controls at all matched glucose levels (P less than 0.001 at all levels). In addition, estimated AIRmax was much lower in diabetics than in controls (83 +/- 21 vs. 450 +/- 93 microU/ml, P less than 0.01). In contrast, PG50 was similar in diabetics and controls (234 +/- 28 vs. 197 +/- 20 mg/dl, P equals NS) and insulin responses in both groups approached or attained maxima at a glucose level of approximately 460 mg/dl. Acute glucagon responses to arginine in patients with NIDDM were significantly higher than responses in controls at all glucose levels. In addition, although glucagon responses in control subjects reached a minimum at a glucose level of approximately 460 mg/dl, responses in diabetics declined continuously throughout the glucose range and did not reach a minimum. Thus, A cell sensitivity to changes in glucose level may be diminished in patients with NIDDM. In summary, patients with NIDDM possess markedly decreased maximal insulin responsiveness to the potentiating effects of glucose. Such a defect indicates the presence of a reduced B cell secretory capacity and suggests a marked generalized impairment of B cell function in patients with NIDDM.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1172/jci111542

Cites

38 of 38 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Exploratory Data Analysis
David, F. N., & Tukey, J. W. (1977) · Biometrics · doi:10.2307/2529486 · Cited by 12,707
Applied Regression Analysis
Hahn, G. J., Draper, N. R., & Smith, H. C. (1982) · Technometrics · doi:10.2307/1267833 · Cited by 5,820
Classification and diagnosis of diabetes mellitus and other categories of glucose intolerance.
National Diabetes Data Group (1979) · Diabetes · doi:10.2337/diab.28.12.1039 · Cited by 4,909
Exploratory Data Analysis
Tukey, J. W. (1977) · International Linear Collider · Cited by 2,155
Studies of pancreatic alpha cell function in normal and diabetic subjects
Unger, R. H., Aguilar-Parada, E., Müller, W. A., & Eisentraut, A. M. (1970) · Journal of Clinical Investigation · doi:10.1172/jci106297 · Cited by 837
Effects of arterial versus venous sampling on analysis of glucose kinetics in man
McGuire, E. A., Helderman, J. H., Tobin, J. D., Andres, R., & Berman, M. D. (1976) · Journal of Applied Physiology · doi:10.1152/jappl.1976.41.4.565 · Cited by 704
A threshold distribution hypothesis for packet storage of insulin and its mathematical modeling
Grodsky, G. M. (1972) · Journal of Clinical Investigation · doi:10.1172/jci107011 · Cited by 391
Insulin secretion in diabetes mellitus
Pfeifer, M. A., Halter, J. B., & Porte, D. (1981) · The American Journal of Medicine · doi:10.1016/0002-9343(81)90579-9 · Cited by 367
Self-citation
The pancreatic islets in diabetes
Gepts, W., & LeCompte, P. M. (1981) · The American Journal of Medicine · doi:10.1016/0002-9343(81)90417-4 · Cited by 348
Glucagon and the a Cell
Unger, R. H., & Orci, L. (1981) · New England Journal of Medicine · doi:10.1056/nejm198106183042504 · Cited by 303

Show all 37 references

Sorted by citations

Items 301–400 of 482

NO‐dependent and ‐independent elevation of plasma levels of insulin and glucose in rats by L‐arginine
Jun, T., & Wennmalm, Å. (1994) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1994.tb16993.x · Cited by 19
Hyperglycaemia is associated with impaired pulsatile insulin secretion: effect of basal insulin therapy
Meier, J. J., Pennartz, C., Schenker, N., Menge, B., Schmidt, W. E., Heise, T., Kapitza, C., & Veldhuis, J. D. (2012) · Diabetes Obesity and Metabolism · doi:10.1111/dom.12022 · Cited by 18
Lixisenatide as add‐on treatment among patients with different β‐cell function levels as assessed by HOMA‐β index
Bonadonna, R. C., Blonde, L., Antsiferov, M. B., Berria, R., Gourdy, P., Hatunic, M., Mohan, V., & Horowitz, M. (2017) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.2897 · Cited by 17
HNF1A and A1CF coordinate a beta cell transcription-splicing axis that is disrupted in type 2 diabetes
Bernardo, E., Vas, M. G. D., Balboa, D., Cuenca-Ardura, M., Bonàs‐Guarch, S., Planas-Fèlix, M., Mollandin, F., Torrens-Dinarès, M., Maestro, M. A., García-Hurtado, J., et al. (2025) · Cell Metabolism · doi:10.1016/j.cmet.2025.07.007 · Cited by 16
GLP-1 Receptor Blockade Reduces Stimulated Insulin Secretion in Fasted Subjects With Low Circulating GLP-1
Gray, S. M., Hoselton, A. L., Krishna, R., Slentz, C. A., & D’Alessio, D. A. (2022) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgac396 · Cited by 15
Prkar1a in the Regulation of Insulin Secretion
Hussain, M. A., Stratakis, C. A., & Kirschner, L. S. (2012) · Hormone and Metabolic Research · doi:10.1055/s-0032-1321866 · Cited by 16
Human Physiology of Genetic Defects Causing Beta-cell Dysfunction
Kettunen, J. L. T., & Tuomilehto, J. (2020) · Journal of Molecular Biology · doi:10.1016/j.jmb.2019.12.038 · Cited by 18
Habitual dietary intake versus glucose tolerance, insulin sensitivity and insulin secretion in postmenopausal women
Larsson, H. E., Elmståhl, S., Berglund, G., & Åhrén, B. (1999) · Journal of Internal Medicine · doi:10.1046/j.1365-2796.1999.00503.x · Cited by 17
Hyperamylinemia is associated with hyperinsulinemia in the glucose-tolerant, insulin-resistant offspring of two Mexican-American non—insulin-dependent diabetic parents
Gulli, G., Rossetti, L., & DeFronzo, R. A. (1997) · Metabolism · doi:10.1016/s0026-0495(97)90209-2 · Cited by 17
Insulin secretion to glucose as well as nonglucose stimuli is impaired in spontaneously diabetic Nagoya-Shibata-Yasuda mice
Hamada, Y., Ikegami, H., Ueda, H., Kawaguchi, Y., Yamato, E., Nojima, K., Yamada, K. D., Babaya, N., Shibata, M. S., & Ogihara, T. (2001) · Metabolism · doi:10.1053/meta.2001.27198 · Cited by 17
Assessment of beta‐cell function in young patients with type 2 diabetes: arginine‐stimulated insulin secretion may reflect beta‐cell reserve
Sjöstrand, M., Carlson, K., Arnqvist, H. J., Guðbjörnsdóttir, S., Landin‐Olsson, M., Lindmark, S., Nyström, L., Svensson, M. K. E., Eriksson, J. W., & Bolinder, J. (2013) · Journal of Internal Medicine · doi:10.1111/joim.12116 · Cited by 16
Islet Dysfunction: An Underlying Defect in the Pathophysiology of Type 2 Diabetes
Pratley, R. E. (2006) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/s0889-8529(07)70004-x · Cited by 16
Association of Habitual Daily Physical Activity With Glucose Tolerance and β-Cell Function in Adults With Impaired Glucose Tolerance or Recently Diagnosed Type 2 Diabetes From the Restoring Insulin Secretion (RISE) Study
Temple, K. A., Tjaden, A. H., Atkinson, K. M., Barengolts, E., Hannon, T. S., Mather, K. J., Utzschneider, K. M., Edelstein, S. L., Ehrmann, D. A., Mokhlesi, B., et al. (2019) · Diabetes Care · doi:10.2337/dc19-0538 · Cited by 16
TIRF Microscopy Analysis of the Mechanism of Insulin Exocytosis
Nagamatsu, S. (2006) · Endocrine Journal · doi:10.1507/endocrj.kr-75 · Cited by 16
Early insulin release effectively improves glucose tolerance: studies in two rodent models of type 2 diabetes mellitus
de Souza, C. J., Gagen, K., Chen, W., & Dragonas, N. (2001) · Diabetes Obesity and Metabolism · doi:10.1046/j.1463-1326.2001.00115.x · Cited by 16
Postprandial hyperglycaemia in type 2 diabetes: pathophysiological aspects, teleological notions and flags for clinical practice
Boutati, E. I., & Raptis, S. (2004) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.528 · Cited by 17
A metabolic redox relay supports ER proinsulin export in pancreatic islet β cells
Rohli, K. E., Stubbe, N. J., Walker, E. M., Pearson, G. L., Soleimanpour, S. A., & Stephens, S. B. (2024) · JCI Insight · doi:10.1172/jci.insight.178725 · Cited by 17
Improved Glycemic Control Enhances the Incretin Effect in Patients With Type 2 Diabetes
An, Z., Prigeon, R. L., & D’Alessio, D. A. (2013) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2013-1199 · Cited by 15
Diabetes/Syndrome X
Schmeltz, L. R., & Metzger, B. E. (2007) · Elsevier eBooks · doi:10.1016/b0-08-045044-x/00179-6 · Cited by 16
Evaluation of β‐cell mass and function in the Göttingen minipig
Larsen, M. O., Rolin, B., Raun, K., Knudsen, L., Gotfredsen, C., & Bock, T. (2007) · Diabetes Obesity and Metabolism · doi:10.1111/j.1463-1326.2007.00785.x · Cited by 13
The plasma C-peptide and insulin responses to stimulation with intravenous glucagon and a mixed meal in well-controlled Type 2 (non-insulin-dependent) diabetes mellitus: dependency on acutely established hyperglycaemia
Gjessing, H. J., Reinholdt, B., & Pedersen, O. (1989) · Diabetologia · doi:10.1007/bf00297450 · Cited by 15
Adaptation to intermittent stress promotes maintenance of β-cell compensation: comparison with food restriction
Bates, H. E., Sirek, A., Kiràly, M. A., Yue, J. T. Y., Riddell, M. C., Matthews, S. G., & Vranić, M. (2008) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.90378.2008 · Cited by 15
Pathophysiology of Canine Diabetes
Hoenig, M. E. (1995) · Veterinary Clinics of North America Small Animal Practice · doi:10.1016/s0195-5616(95)50052-x · Cited by 14
Hyperglycemic clamp-derived disposition index is negatively associated with metabolic syndrome severity in obese subjects
Shah, S. S., Ramirez, C. E., Powers, A. C., Yu, C., Shibao, C. A., & Luther, J. M. (2016) · Metabolism · doi:10.1016/j.metabol.2016.02.011 · Cited by 14
Early Metabolic Markers That Anticipate Loss of Insulin Independence in Type 1 Diabetic Islet Allograft Recipients
Hirsch, D., Odorico, J. S., Danobeitia, J. S., Alejandro, R., Rickels, M. R., Hanson, M. S., Radke, N. A., Baidal, D. A., Hullett, D. A., Naji, A., et al. (2012) · American Journal of Transplantation · doi:10.1111/j.1600-6143.2011.03947.x · Cited by 14
Role of GLP-1 induced glucagon suppression in type 2 diabetes mellitus.
Hare, K. J. (2010) · PubMed · Cited by 14
Cytochemical localization of NADPH-diaphorase in the four types of pancreatic islet cell
Bouwens, L., & Kl�ppel, G. (1994) · Histochemistry and Cell Biology · doi:10.1007/bf00269546 · Cited by 14
Impaired β-cell sensitivity to glucose and maximal insulin secretory capacity in adolescents with type 2 diabetes
Elder, D. A., Woo, J. G., & D’Alessio, D. A. (2009) · Pediatric Diabetes · doi:10.1111/j.1399-5448.2009.00601.x · Cited by 14
Targeting SUR1/Abcc8-Type Neuroendocrine KATP Channels in Pancreatic Islet Cells
Nakamura, Y., & Bryan, J. (2014) · PLoS ONE · doi:10.1371/journal.pone.0091525 · Cited by 14
The effect of various blood glucose levels on post-glucagon C-peptide secretion in type 2 (non insulin-dependent) diabetes
Nosari, I., Lepore, G., Maglio, M. L., Cortinovis, F., & Pagani, G. A. (1992) · Journal of Endocrinological Investigation · doi:10.1007/bf03348682 · Cited by 14
AIRarg and AIRgluc as predictors of insulin secretory reserve
Robertson, R. P. (2004) · Transplantation Proceedings · doi:10.1016/j.transproceed.2004.04.014 · Cited by 14
Non‐insulin dependent diabetes mellitus: defects in insulin secretion
Wolffenbuttel, B. H. R., & van Haeften, T. W. (1993) · European Journal of Clinical Investigation · doi:10.1111/j.1365-2362.1993.tb00743.x · Cited by 14
Insulin Secretion in Diabetes Mellitus
Cerasi, E. (1988) · Springer eBooks · doi:10.1007/978-3-642-72691-0_11 · Cited by 14
In vivo β-cell function at the transition to early non-insulin-dependent diabetes mellitus
Swinburn, B. A., Gianchandani, R. Y., Saad, M. F., & Lillioja, S. (1995) · Metabolism · doi:10.1016/0026-0495(95)90189-2 · Cited by 14
James Lind Alliance research priorities: what role do carbohydrates, fats and proteins have in the management of Type 2 diabetes, and are there risks and benefits associated with particular approaches?
Dyson, P. A., McArdle, P., Mellor, D. D., & Guess, N. D. (2018) · Diabetic Medicine · doi:10.1111/dme.13826 · Cited by 15
Ovarian insufficiency impairs glucose-stimulated insulin secretion through activation of hypothalamic de novo ceramide synthesis
Meneyrol, K., Estévez‐Salguero, Á., González‐García, I., Guitton, J., Taouis, M., Benomar, Y., Magnan, C., López, M., & Stunff, H. L. (2021) · Metabolism · doi:10.1016/j.metabol.2021.154846 · Cited by 12
Incretin-based therapy and pancreatic beta cells
Chon, S., Riveline, J., Blondeau, B., & Gautier, J. (2014) · Diabetes & Metabolism · doi:10.1016/j.diabet.2014.05.003 · Cited by 12
Hyperglycemia abolishes meal-induced satiety by a dysregulation of ghrelin and peptide YY3–36 in healthy overweight/obese humans
Knudsen, S. H., Karstoft, K., & Solomon, T. P. J. (2013) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00563.2013 · Cited by 12
Pathophysiology of Insulin Secretion in Diabetes Mellitus
Ward, W. K., Beard, J. C., Halter, J. B., & Porte, D. (1985) · Advances in experimental medicine and biology · doi:10.1007/978-1-4757-1850-8_9 · Cited by 12
Self-citation
The Effect of Chronic Hyperglycaemia on the Islet B‐cell Responsiveness in Newly Diagnosed Type 2 Diabetes
Gjessing, H. J., Reinhold, B., & Pedersen, O. (1992) · Diabetic Medicine · doi:10.1111/j.1464-5491.1992.tb01853.x · Cited by 12
Prospective evaluation of β-cell function in insulin antoantibody-positive relatives of insulin-dependent diabetic patients
Neifing, J. L., Greenbaum, C. J., Kahn, S. E., McCulloch, D. K., Bärmeier, H., Lernmark, Å., & Palmer, J. P. (1993) · Metabolism · doi:10.1016/0026-0495(93)90107-y · Cited by 12
Addressing the insulin secretion defect: A logical first-line approach
Gerich, J. E. (2000) · Metabolism · doi:10.1053/meta.2000.17824 · Cited by 12
Mechanism(s) of the blood glucose lowering action of benfluorex
Riccio, A., de Kreutzenberg, S. V., Dorella, M., Tos, V. D., Biasi, L., Marescotti, M. C., Tiengo, A., & Prato, S. D. (1993) · Diabetes/Metabolism Reviews · doi:10.1002/dmr.5610090505 · Cited by 12
Effect of 24-week treatment with ipragliflozin on proinsulin/C-peptide ratio in Japanese patients with type 2 diabetes
Nagai, Y., Ohta, A., Sada, Y., Kato, H., & Tanaka, Y. (2016) · Expert Opinion on Pharmacotherapy · doi:10.1080/14656566.2016.1261110 · Cited by 11
Non-glucose modulators of insulin secretion in healthy humans: (dis)similarities between islet and in vivo studies
Henquin, J. (2021) · Metabolism · doi:10.1016/j.metabol.2021.154821 · Cited by 13
Early clinical studies with liraglutide
Schmidt, W. E. (2010) · International Journal of Clinical Practice · doi:10.1111/j.1742-1241.2010.02500.x · Cited by 11
Affected sib-pair analysis of the GLUT1 glucose transporter gene locus in non-insulin-dependent diabetes mellitus (NIDDM): evidence for no linkage
Baroni, M. G., Alcolado, J. C., Gragnoli, C., Franciosi, A., Cavallo, M. G., Fiore, V., Pozzilli, P., & Galton, D. J. (1994) · Human Genetics · doi:10.1007/bf00201569 · Cited by 10
Beta cell function in the preclinical period of insulin‐dependent diabetes
McCulloch, D. K., Palmer, J. P., & Benson, E. A. (1987) · Diabetes/Metabolism Reviews · doi:10.1002/dmr.5610030102 · Cited by 10
Association between 1,5-Anhydroglucitol and Acute C Peptide Response to Arginine among Patients with Type 2 Diabetes
Shen, Y., Si, Y., Lu, J., Ma, X., Zhang, L., Mo, Y., Lu, W., Zhu, W., Bao, Y., Hu, G., et al. (2020) · Journal of Diabetes Research · doi:10.1155/2020/4243053 · Cited by 10
Induction of remission in diabetes by lowering blood glucose
Weir, G. C., & Bonner‐Weir, S. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1213954 · Cited by 13
Impact of insulin glargine and lixisenatide on β‐cell function in patients with type 2 diabetes mellitus: A randomized open‐label study
Meier, J. J., Schenker, N., Kahle, M., Schliess, F., Kapitza, C., & Menge, B. A. (2017) · Diabetes Obesity and Metabolism · doi:10.1111/dom.12968 · Cited by 10
Response : Nitric Oxide and Arginine-Evoked Insulin Secretion
Schmidt, H. H. H. W., Warner, T. D., Ishii, K., Sheng, H., & Murad, F. (1992) · Science · doi:10.1126/science.258.5086.1376-b · Cited by 10
Function and survival of intrasplenic islet autografts in dogs
Burg, M. P. M. V. D., Guicherit, O. R., Jansen, J. B. �. �., Frölich, M. A., Lamers, C. B. H. W., Lemkes, H. H. P. J., Bruijn, J. A., & Gooszen, H. G. (1996) · Diabetologia · doi:10.1007/bf00400411 · Cited by 10
Insulin analogues: New therapies for type 2 diabetes mellitus
Bethel, M. A., & Feinglos, M. N. (2002) · Current Diabetes Reports · doi:10.1007/s11892-002-0104-4 · Cited by 10
Porcine Islet Adaptation to Metabolic Need of Monkeys in Pig-to-Monkey Intraportal Islet Xenotransplantation
Lee, J.-I., Shin, J., Jung, W.-Y., Lee, G., Kim, M.-S., Kim, Y.-S., Choi, J. W., Park, C., & Kim, S.-J. (2013) · Transplantation Proceedings · doi:10.1016/j.transproceed.2013.01.090 · Cited by 9
Verapamil and Its Role in Diabetes
Zimmermann, P., Aberer, F., Eckstein, M. L., Haupt, S., Erlmann, M. P., & Moser, O. (2022) · Diabetology · doi:10.3390/diabetology3030030 · Cited by 10
What Not to Overlook in the Management of Patients with Type 2 Diabetes Mellitus: The Nephrological and Hepatological Perspectives
Alfieri, C., Molinari, P., Cinque, F., Vettoretti, S., Cespiati, A., Bignamini, D., Nardelli, L., Fracanzani, A. L., Castellano, G., & Lombardi, R. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25147728 · Cited by 10
Comparison of the hypoglycemic effect of sitagliptin versus the combination of mitiglinide and voglibose in drug-naïve Japanese patients with type 2 diabetes
Ohta, A., Ohshige, T., Sakai, K., Nakamura, Y., Tenjin, A., Tsukiyama, S., Terashima, Y., Matsubara, F., Kawata, T., Nagai, Y., et al. (2013) · Expert Opinion on Pharmacotherapy · doi:10.1517/14656566.2013.842554 · Cited by 9
Sequential Treatment Escalation with Dapagliflozin and Saxagliptin Improves Beta Cell Function in Type 2 Diabetic Patients on Previous Metformin Treatment: An Exploratory Mechanistic Study
Forst, T. M., Alghdban, M., Fischer, A., Weber, M. M., Voswinkel, S., Heise, T., Kapitza, C., & Plum‐Mörschel, L. (2018) · Hormone and Metabolic Research · doi:10.1055/a-0591-9442 · Cited by 9
Different β‐cell secretory phenotype in non‐obese compared to obese early type 2 diabetes
Gudipaty, L., Rosenfeld, N. K., Fuller, C. S., Cuchel, M., & Rickels, M. R. (2020) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.3295 · Cited by 9
Analysis of coding variants in the betacellulin gene in type 2 diabetes and insulin secretion in African American subjects
Elbein, S. C., Wang, X., Karim, M. A., Chu, W. S., & Silver, K. D. (2006) · BMC Medical Genetics · doi:10.1186/1471-2350-7-62 · Cited by 9
Reduced glucose effectiveness as a feature of glucose intolerance: Evidence in elderly Type-2 diabetic subjects
Viviani, G. L., & Pacini, G. (1999) · Aging Clinical and Experimental Research · doi:10.1007/bf03399659 · Cited by 9
Abnormalities of Insulin Secretion and β‐Cell Defects in Type 2 Diabetes
Alsahli, M., & Gerich, J. E. (2010) · Wiley eBooks · doi:10.1002/9781444324808.ch10 · Cited by 11
The Genetics and Pathophysiology of Type II and Gestational Diabetes
Csorba, T. R., Edwards, A. L., & Tan, M. H. (1995) · Critical Reviews in Clinical Laboratory Sciences · doi:10.3109/10408369509082593 · Cited by 9
Islet amyloid polypeptide response to maximal hyperglycemia and arginine is altered in impaired glucose tolerance and type 2 diabetes mellitus
Guardado‐Mendoza, R., Chávez, A. O., Jiménez-Ceja, L. M., HANSIS-DIARTE, A. A., DeFronzo, R. A., Folli, F. B., & Tripathy, D. (2016) · Acta Diabetologica · doi:10.1007/s00592-016-0904-7 · Cited by 8
Efficacy and safety of Chinese herbal medicine on blood glucose fluctuations in patients with type 2 diabetes mellitus
Leng, Y., Zhou, X., Xie, Z., Hu, Z., Gao, H., Liu, X., Xie, H., Fu, X., & Xie, C. (2020) · Medicine · doi:10.1097/md.0000000000021904 · Cited by 8
Living Donor Pancreas Transplantation
Gruessner, R. W. G. (2004) · Springer eBooks · doi:10.1007/978-1-4757-4371-5_14 · Cited by 8
Proportional proinsulin responses in first-degree relatives of patients with type 2 diabetes mellitus
R�der, M. E., Eriksson, J. G., HARTLING, S. G., Groop, P., & Binder, C. (1993) · Acta Diabetologica · doi:10.1007/bf00572856 · Cited by 8
Gliclazide and bedtime insulin are more efficient than insulin alone for type 2 diabetic patients with sulfonylurea secondary failure
Chazan, A. C. S., & Gomes, M. B. (2001) · Brazilian Journal of Medical and Biological Research · doi:10.1590/s0100-879x2001000100006 · Cited by 8
β‐Cell Dysfunction in Type 2 Diabetes
Utzschneider, K. M., & Kahn, S. E. (2003) · Wiley eBooks · doi:10.1002/0470862092.d0403 · Cited by 8
Functional adaptation of the human β‐cells after frequent exposure to noradrenaline
Dela, F. (2015) · Journal of Physiology · doi:10.1113/jp270486 · Cited by 5
Impaired phasic insulin and amylin secretion in diabetic rats
Leahy, J. L., & Fineman, M. S. (1998) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1998.275.3.e457 · Cited by 7
A new perspective of probe development for imaging pancreatic beta cell in vivo.
Neo, C. W. Y., Ciaramicoli, L. M., Soetedjo, A. A. P., Teo, A., & Kang, N.-Y. (2020) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2020.01.009 · Cited by 8
Detour Ahead: Incretin Hormone Signaling Alters Its Intracellular Path as β-Cell Failure Progresses During Diabetes
Hussain, M. A., Laimon-Thomson, E. L., Mustafa, S. M., Deck, A., & Song, B. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.665345 · Cited by 8
Arginine Thiazolidine Carboxylate Stimulates Insulin Secretion through Production of Ca2+-Mobilizing Second Messengers NAADP and cADPR in Pancreatic Islets
Park, D., Shawl, A. I., Ha, T., Park, K.-H., Kim, S.-Y., & Kim, U. (2015) · PLoS ONE · doi:10.1371/journal.pone.0134962 · Cited by 7
Quantitative and qualitative differences in basal and glucose- and arginine-stimulated insulin secretion in healthy subjects and different stages of NIDDM
Ratheiser, K., Reitgruber, W., Komjati, M., Bratusch-Marrain, P. R., Vierhapper, H., & Waldhäusl, W. K. (1990) · Acta Diabetologica · doi:10.1007/bf02581332 · Cited by 7
Roux-en-Y Gastric Bypass Is Associated With Hyperinsulinemia But Not Increased Maximal β-Cell Function
Georgia, A., Asnis, M. C. C., Febres, G., Tsang, A., Bessler, M., & Körner, J. (2019) · Journal of the Endocrine Society · doi:10.1210/js.2018-00213 · Cited by 7
Impact of a mild decrease in fasting plasma glucose on β-cell function in healthy subjects and patients with type 2 diabetes
Seghieri, M., Rebelos, E., Astiarraga, B., Baldi, S., Mari, A., & Ferrannini, E. (2016) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00428.2015 · Cited by 7
Therapy targeting β-cell survival and function in type 2 diabetes mellitus
Pørksen, N. K. (2006) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2006.06.014 · Cited by 7
Glucoregulation after Canine Islet Transplantation: Contribution of Insulin Secretory Capacity, Insulin Action, and the Entero-Insular Axis
Burg, M. P. M. V. D., van Suylichem, P. T. R., Guicherit, O. R., Frölich, M., Lemkes, H. H. P. J., & Gooszen, H. G. (1997) · Cell Transplantation · doi:10.1016/s0963-6897(97)00050-x · Cited by 7
Regulation of Insulin Secretion in Vivo
Vidal, J., & Kahn, S. E. (2001) · Endocrine updates · doi:10.1007/978-1-4615-1597-5_7 · Cited by 7
Insulin and Glucagon Secretion in vivo and its Neural Control
Taborsky, G. J. (2001) · Comprehensive physiology · doi:10.1002/cphy.cp070206 · Cited by 7
IDENTIFYING BREED DIFFERENCES IN INSULIN DYNAMICS, SKELETAL MUSCLE AND ADIPOSE TISSUE HISTOLOGY AND GENE EXPRESSION
Manfredi, J. M. (2016) · Michigan State University Libraries · doi:10.25335/8bxe-b906 · Cited by 8
The effects of food on the pharmacokinetics of mitiglinide tablets in healthy volunteers and a novel mass-spectrometric (UPLC-MS/MS) method for such studies
Zhang, J., Cai, L., Peng, W.-X., Zhu, R.-H., Yang, J., & Zhang, Q.-Z. (2011) · Journal of Clinical Pharmacy and Therapeutics · doi:10.1111/j.1365-2710.2011.01257.x · Cited by 6
IS BETA CELL DYSFUNCTION RESPONSIBLE FOR FLAT GLUCOSE TOLERANCE CURVE IN PRIMARY HYPOTHYROIDISM? (A HYPOTHESIS)
Pakhetra, R., Garg, M., & SAINI, J. (2001) · Medical Journal Armed Forces India · doi:10.1016/s0377-1237(01)80129-5 · Cited by 6
Effect of the Incretin Hormones on the Endocrine Pancreas in End-Stage Renal Disease
Jørgensen, M. B., Idorn, T., Rydahl, C., Hansen, H. P., Bressendorff, I. O., Brandi, L., Albrechtsen, N. J. W., van Hall, G., Hartmann, B., Holst, J. J., et al. (2019) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgz048 · Cited by 7
Precision and accuracy of hyperglycemic clamps in a multicenter study
Mather, K. J., Tjaden, A. H., Hoehn, A., Nadeau, K. J., Buchanan, T. A., Kahn, S. E., Arslanian, S. A., Caprio, S., Atkinson, K. M., Cree‐Green, M., et al. (2021) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00598.2020 · Cited by 5
The beta-cell response to glucagon and mixed meal stimulation in non-insulin dependent diabetes
Gjessing, H. J., Damsgaard, E. M. S., Matzen, L. H., FABER, O. K., & Frøland, A. (1988) · Scandinavian Journal of Clinical and Laboratory Investigation · doi:10.3109/00365518809088759 · Cited by 6
Obesity and Type 2 Diabetes Mellitus: A Treatment Challenge
Gumbiner, B., & Battiwala, M. (2002) · The Endocrinologist · doi:10.1097/00019616-200201000-00007 · Cited by 6
Mechanism of Impaired Glucose-potentiated Insulin Secretion in Diabetic 90% Pancreatectomy Rats
Hosokawa, Y., Hosokawa, H., Chen, C., & Leahy, J. L. (2016) · Cited by 5
Fasting, Postprandial and Postprandial plus Glucagon‐stimulated Plasma C‐peptide Levels in Non‐insulin‐dependent Diabetics and in Control Subjects
Sarlund, H., Laakso, M., Pyörälà, K., & Penttilä, I. (1987) · Acta Medica Scandinavica · doi:10.1111/j.0954-6820.1987.tb03359.x · Cited by 5
The effect of Nateglinide taken with food on gastric emptying rates in healthy subjects
Anderson, D., Shelley, S., Kellett, N., Marshall, D., & Nimmo, W. S. (2003) · Clinical Therapeutics · doi:10.1016/s0149-2918(03)80165-0 · Cited by 5
Effect of Medical and Surgical Interventions on α-Cell Function in Dysglycemic Youth and Adults in the RISE Study
Kahn, S. E., Edelstein, S. L., Arslanian, S. A., Barengolts, E., Caprio, S., Ehrmann, D. A., Hannon, T. S., Marcovina, S. M., Mather, K. J., Nadeau, K. J., et al. (2021) · Diabetes Care · doi:10.2337/dc21-0461 · Cited by 6
The Role of the Liver in Insulin Action and Resistance
Radziuk, J., & Pye, S. (1999) · Humana Press eBooks · doi:10.1007/978-1-59259-716-1_11 · Cited by 5
Advances in the Treatment of Diabetes Mellitus in the Elderly
Hoogwerf, B. J., Mehta, A., & Reddy, S. S. K. (1996) · Drugs & Aging · doi:10.2165/00002512-199609060-00006 · Cited by 5
Pathogenesis of Type 2 Diabetes
Cusi, K. J., & DeFronzo, R. A. (2001) · Comprehensive physiology · doi:10.1002/cphy.cp070237 · Cited by 5
Nutrient metabolism regulates insulin granule formation in the pancreatic islet β-cell via ER redox homeostasisPreprint
Rohli, K. E., Boyer, C. K., Bearrows, S. C., Moyer, M. R., Elison, W. S., Bauchle, C. J., Blom, S. E., Yu, C.-L., Pope, M. R., Zhang, J., et al. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.09.22.461417 · Cited by 5
Pancreatic β‐cell turnover in health and disease
Alcibahy, Y., Darwish, R., Butler, A. E., & Moin, A. S. M. (2025) · Diabetes Obesity and Metabolism · doi:10.1111/dom.70191 · Cited by 5
Type 2 Diabetes Mellitus
Hupfeld, C. J., & Olefsky, J. M. (2015) · Elsevier eBooks · doi:10.1016/b978-0-323-18907-1.00040-8 · Cited by 7
Effect of nifedipine on glucose potentiation of the acute insulin response to arginine in non-insulin-dependent diabetics
Krempf, M., Ranganatan, S., Ritz, P., Garnier, J., & Charbonnel, B. H. (1991) · European Journal of Clinical Pharmacology · doi:10.1007/bf00626361 · Cited by 4

Authors: Ward, W. K., Bolgiano, D. C., McKnight, B., Halter, J. B., & Porte, D.
Affiliations: University of Washington (US)
United States Department of Veterans Affairs (US)
Venue: Journal of Clinical Investigation
Publisher: American Society for Clinical Investigation
Published: 1984-10-01
Volume: 74
Issue: 4
Pages: 1318-1328
ISSN: 0021-9738 (ISSN-L)
DOI: 10.1172/jci111542
PMC: PMC425299
OpenAlex: W1969480413
Cited by: 483
References: 37
Citations by year: 2026: 1 · 2025: 7 · 2024: 7 · 2023: 6 · 2022: 6 · 2021: 12 · 2020: 13 · 2019: 10 · 2018: 13 · 2017: 8 · 2016: 19 · 2015: 10 · 2014: 19 · 2013: 14 · 2012: 14
FWCI: 10.29
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Journal of Clinical Investigation (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (5p30am017047-11, 5r01am012829-17)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pancreatic function and diabetes
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Diabetes and associated disorders
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
Keywords: type 2 diabetes, insulin secretion, acute insulin response, arginine stimulation, glucagon response, glucose-stimulated insulin secretion, hyperglycemia, Michaelis-Menten kinetics
MeSH terms: Insulin Secretion, Adult, Aging, Arginine, Blood Glucose, Catecholamines, Diabetes Mellitus, Diabetes Mellitus, Type 2, Glucagon, Humans, Insulin, Islets of Langerhans, Male, Middle Aged, Obesity

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Diminished B cell secretory capacity in patients with noninsulin-dependent diabetes mellitus

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks