The DOI matches its Crossref record.
Protein-bound homocyst(e)ine. A possible risk factor for coronary artery disease.
Open accessAbstract
The development of atherosclerotic changes and thromboembolism are common features in homocystinurics. Hence, we postulate a positive correlation between the level of homocyst(e)ine in the blood and the occurrence of coronary artery disease. Homocysteine is found either as free homocystine, cysteine-homocysteine mixed disulfide, or protein-bound homocyst(e)ine. In nonhomocystinuric subjects, most homocysteine molecules are detectable in the protein-bound form. Thus, protein-bound homocyst(e)ine in stored plasma which reflected total plasma homocyst(e)ine was determined in 241 patients with coronary artery disease (173 males and 68 females). The mean +/- SD total plasma homocyst(e)ine was 5.41 +/- 1.62 nmol/ml in male patients, 4.37 +/- 1.09 nmol/ml in male controls, 5.66 +/- 1.93 nmol/ml in female patients, and 4.16 +/- 1.62 nmol/ml in female controls. The differences between the patients with coronary artery disease and the controls were statistically significant (P less than 0.0005).
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
Homocysteine and Cardiovascular Disease
Refsum, H., Ueland, P. M., Nygård, O., & Vollset, S. E. (1998) · Annual Review of Medicine · doi:10.1146/annurev.med.49.1.31 · Cited by 2,180
Diet and Health: What Should We Eat?
Willett, W. C. (1994) · Science · doi:10.1126/science.8160011 · Cited by 1,008
Rapid high-performance liquid chromatographic assay for total homocysteine levels in human serum
Ubbink, J. B., Hayward Vermaak, W. J., & Bissbort, S. (1991) · Journal of Chromatography B: Biomedical Sciences and Applications · doi:10.1016/0378-4347(91)80407-4 · Cited by 678
Homocyst(e)ine Decreases Bioavailable Nitric Oxide by a Mechanism Involving Glutathione Peroxidase
Upchurch, G. R., Welch, G. N., Fabian, A. J., Freedman, J. E., Johnson, J. L., Keaney, J. F., & Loscalzo, J. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.27.17012 · Cited by 668
Folic acid—an innocuous means to reduce plasma homocysteine
Brattström, L. E., Israelsson, B., Jeppsson, J.-O., & Hultberg, B. L. (1988) · Scandinavian Journal of Clinical and Laboratory Investigation · doi:10.3109/00365518809167487 · Cited by 363
Metadata
- Authors
- Kang, S. S., Wong, P. W., Cook, H. Y., Norusis, M., & Messer, J. V.
- Venue
- Journal of Clinical Investigation
- Published
- 1986-05-01
- Volume
- 77
- Issue
- 5
- Pages
- 1482-1486
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W2031374350
- Cited by
- 302
- References
- 0
- FWCI
- 10.57
- Type
- journal article
- Language
- en
- Open access
- bronze
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Protein-bound homocyst(e)ine. A possible risk factor for coronary artery disease. https://app.cochat.ai/papers/10.1172/jci112461
- The paper
- Kang, S. S., Wong, P. W., Cook, H. Y., Norusis, M., & Messer, J. V. (1986). Protein-bound homocyst(e)ine. A possible risk factor for coronary artery disease. Journal of Clinical Investigation. https://doi.org/10.1172/jci112461
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
