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Free 25-hydroxyvitamin D levels are normal in subjects with liver disease and reduced total 25-hydroxyvitamin D levels.
Open accessAbstract
We determined the free fraction of 25-dihydroxyvitamin D (25OHD) in the serum of subjects with clinical evidence of liver disease and correlated these measurements to the levels of vitamin D binding protein and albumin. These subjects when compared to normal individuals had lower total 25OHD levels, higher percent free 25OHD levels, but equivalent free 25OHD levels. These subjects also had reduced vitamin D binding protein and albumin concentrations. The total concentration of 25OHD correlated positively with both vitamin D binding protein and albumin, whereas the percent free 25OHD correlated negatively with vitamin D binding protein and albumin. The free 25OHD levels did not correlate with either vitamin D binding protein or albumin. We conclude that total vitamin D metabolite measurements may be misleading in the evaluation of the vitamin D status of patients with liver disease, and recommend that free 25OHD levels also be determined before making a diagnosis of vitamin D deficiency.
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Free 25(OH)D is more appropriate than total 25(OH)D for assessing vitamin D status when DBP levels are altered (CKD, obesity, liver problems).
“Valorization of a patient’s vitamin D status in clinical settings where DBP levels are altered, such as CKD, obesity and liver problems, has also been deemed more appropriate when using free serum 25(OH)D as compared to total serum 25(OH)D [243–246].”
From Role of sex hormone-binding globulin in the free hormone hypothesis and the relevance of free testosterone in androgen physiology (2022) · cites this paper as [243]
The Introduction says total 25(OH)D may not accurately indicate vitamin D status in patients with liver disease, and the Discussion says free 25(OH)D measurement could provide important additional information for those patients. These passages support the liver-disease portion, but do not establish that free 25(OH)D is preferable in CKD or obesity. (LLM, conf=0.88)
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Research works printed but not linked: 1
- Bikle, D. D., E. Gee, B. Halloran, M. A. Kowalski, E. Ryzen, and J. G. Haddad. 1986. Assessment ofthe free fraction of 25-hydroxy- vitamin D in serum and its regulation by albumin and vitamin D-binding protein. J. Clin. Endocrinol. Metab. In press.
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Narinx, N., David, K., Walravens, J., Vermeersch, P., Claessens, F., Fiers, T., Lapauw, B., Antonio, L., & Vanderschueren, D. (2022) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-022-04562-1 · Cited by 96
Early increase of bone resorption in patients with liver cirrhosis secondary to viral hepatitis
Corazza, G. R., Trevisani, F., Di Stefano, M., De Notariis, S., Veneto, G., Cecchetti, L., Minguzzi, L., Gasbarrini, G., & Bernardi, M. (2000) · Digestive Diseases and Sciences · doi:10.1023/a:1005568406664 · Cited by 53
Metadata
- Authors
- Bikle, D. D., Halloran, B. P., Gee, E., Ryzen, E., & Haddad, J. G.
- Affiliations
- University of Southern California (US)
- University of Pennsylvania (US)
- Venue
- Journal of Clinical Investigation
- Published
- 1986-09-01
- Volume
- 78
- Issue
- 3
- Pages
- 748-752
- ISSN
- 0021-9738 (ISSN-L)
- PMC
- PMC423667
- OpenAlex
- W2019426469
- Cited by
- 158
- References
- 0
- Citations by year
- 2025: 1 · 2024: 2 · 2023: 6 · 2022: 12 · 2021: 6 · 2020: 8 · 2019: 10 · 2018: 9 · 2017: 7 · 2016: 6 · 2015: 4 · 2014: 5 · 2013: 5 · 2012: 4
- FWCI
- 5.09
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Clinical Investigation (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (AM 28116)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Vitamin D Research Studies
- Health Sciences › Nursing › Nutrition and Dietetics › Vitamin K Research Studies
- Health Sciences › Medicine › Nephrology › Parathyroid Disorders and Treatments
- Keywords
- 25-hydroxyvitamin D, free vitamin D, vitamin D binding protein, serum albumin, liver disease, vitamin D deficiency, vitamin D status assessment
- MeSH terms
- Adult, Aged, Calcifediol, Centrifugation, False Negative Reactions, Female, Humans, Liver Diseases, Male, Middle Aged, Protein Binding, Serum Albumin, Ultrafiltration, Vitamin D-Binding Protein
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