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Human recombinant erythropoietin promotes differentiation of murine megakaryocytes in vitro.
Open accessAbstract
To determine if erythropoietin affects megakaryocytopoiesis, we measured acetylcholinesterase (AchE) activity, a marker of the murine megakaryocytic lineage, after the addition of human recombinant erythropoietin to serumless murine bone marrow cultures. Erythropoietin increased AchE activity substantially. Moreover, when the hormone was added to serumless cultures of 426 isolated single megakaryocytes derived from megakaryocytic colonies, erythropoietin induced a significant increase in the diameters of these cells. From a Bayesian analysis of the likelihood that some megakaryocytes increased in DNA content during the culture period, we estimate that 61% of the cells increased in ploidy. These data indicate that the action of erythropoietin is not restricted to the erythroid lineage.
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Citations
Cited by
The Human Hematopoietic Colony-Stimulating Factors
Clark, S. C., & Kamen, R. (1987) · Science · doi:10.1126/science.3296190 · Cited by 1,639
PLATELET-DERIVED GROWTH FACTOR
Ross, R. (1989) · The Lancet · doi:10.1016/s0140-6736(89)92760-8 · Cited by 940
Krantz, S. (1991) · Blood · doi:10.1182/blood.v77.3.419.419 · Cited by 855
Eschbach, J. W., Abdulhadi, M. H., Browne, J. K., Delano, B. G., Downing, M. R., Egrie, J. C., Evans, R. W., Friedman, E. A., Graber, S. E., Haley, N. R., et al. (1989) · Annals of Internal Medicine · doi:10.7326/0003-4819-111-12-992 · Cited by 795
Thrombopoietin: the primary regulator of platelet production [see comments]
Kaushansky, K. (1995) · Blood · doi:10.1182/blood.v86.2.419.bloodjournal862419 · Cited by 642
Metadata
- Authors
- Ishibashi, T., Koziol, J. A., & Burstein, S. A.
- Venue
- Journal of Clinical Investigation
- Published
- 1987-01-01
- Volume
- 79
- Issue
- 1
- Pages
- 286-289
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W1972987136
- Cited by
- 185
- References
- 0
- FWCI
- 11.05
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Ishibashi, T., Koziol, J. A., & Burstein, S. A. (1987). Human recombinant erythropoietin promotes differentiation of murine megakaryocytes in vitro. Journal of Clinical Investigation. https://doi.org/10.1172/jci112796
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