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Distribution of glucose transporter messenger RNA transcripts in tissues of rat and man.
Open accessAbstract
We used the complementary DNA for the human hepatoma Hep G2 glucose transporter to determine the distribution of glucose transporter messenger RNA (mRNA) in rat and human tissues. Under stringent hybridization conditions, a single 2.8-kilobase (kb) transcript is seen in all rat and human tissues examined. The mRNA is most abundant in brain, and is especially enriched in the brain microvascular fraction. The mRNA abundance in rat muscle and fat is 5% that in brain. Rat liver (both adult and fetal) and human liver have very little 2.8-kb mRNA, but it is abundant in cultured human fibroblasts and EB virus-transformed lymphoblasts. The same size mRNA is present in leg muscle of two type II diabetic patients. A very homologous glucose transporter mRNA is expressed in both insulin-sensitive and -insensitive tissues of rat and man. Hepatocytes, which have abundant glucose transport, may express a homologous but nonidentical glucose transporter.
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Citations
Cited by
Drug Transport across the Blood–Brain Barrier
Pardridge, W. M. (2012) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2012.126 · Cited by 1,994
De Vivo, D. C., Trifiletti, R. R., Jacobson, R. I., Ronen, G. M., Behmand, R. A., & Harik, S. I. (1991) · New England Journal of Medicine · doi:10.1056/nejm199109053251006 · Cited by 800
The glucose transporter family: structure, function and tissue-specific expression
Gould, G. W., & Holman, G. D. (1993) · Biochemical Journal · doi:10.1042/bj2950329 · Cited by 785
Flier, J. S., Mueckler, M. M., Usher, P., & Lodish, H. F. (1987) · Science · doi:10.1126/science.3103217 · Cited by 786
Self-citationThorens, B., Sarkar, H. K., Kaback, H. R., & Lodish, H. F. (1988) · Cell · doi:10.1016/0092-8674(88)90051-7 · Cited by 786
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Metadata
- Authors
- Flier, J. S., Mueckler, M., McCall, A. L., & Lodish, H. F.
- Venue
- Journal of Clinical Investigation
- Published
- 1987-02-01
- Volume
- 79
- Issue
- 2
- Pages
- 657-661
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W2030345672
- Cited by
- 189
- References
- 0
- FWCI
- 8.32
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Flier, J. S., Mueckler, M., McCall, A. L., & Lodish, H. F. (1987). Distribution of glucose transporter messenger RNA transcripts in tissues of rat and man. Journal of Clinical Investigation. https://doi.org/10.1172/jci112864
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