The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Effect of chronic hyperglycemia on in vivo insulin secretion in partially pancreatectomized rats.
Open accessAbstract
We have examined the effect of chronic (4 wk) hyperglycemia on insulin secretion in vivo in an awake, unstressed rat model. Three groups of animals were examined: control, partial (90%) pancreatectomy, and partial pancreatectomy plus phlorizin, in order to normalize plasma glucose levels. Insulin secretion in response to arginine (2 mM), hyperglycemia (+100 mg/dl), and arginine plus hyperglycemia was evaluated. In diabetic compared with control animals three specific alterations were observed: (a) a deficient insulin response, in both first and second phases, to hyperglycemia; (b) an augmented insulin response to the potentiating effect of arginine under basal glycemic conditions; and (c) an inability of hyperglycemia to augment the potentiating effect of arginine above that observed under basal glycemic conditions. Normalization of the plasma glucose profile by phlorizin treatment in diabetic rats completely corrected all three beta cell abnormalities. These results indicate that chronic hyperglycemia can lead to a defect in in vivo insulin secretion which is reversible when normoglycemia is restored.
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Cites
Henry, R. R., Wallace, P., & Olefsky, J. M. (1986) · Diabetes · doi:10.2337/diab.35.9.990 · Cited by 325 · cited 1×
“Thus, acute (41) and chronic (42) caloric restriction, intensified insulin therapy (43), and sulfonylurea drugs (44, 45) all result in a significant lowering of the plasma glucose concentration and a concomitant increase in insulin secretion which may be sustained even after the therapy is”
BackgroundBlood-Brain Glucose Transfer: Repression in Chronic Hyperglycemia
Gjedde, A., & Crone, C. (1981) · Science · doi:10.1126/science.7027439 · Cited by 235 · cited 1×
“Other investigators have shown that hyperglycemia can down-regulate the glucose transport system in noninsulin dependent tissues, such as the cerebral cortex (35, 36).”
BackgroundGerich, J. E., Charles, M. A., & Grodsky, G. M. (1974) · Journal of Clinical Investigation · doi:10.1172/jci107823 · Cited by 230
The Acute and Chronic Effects of Sulfonylurea Therapy in Type II Diabetic Subjects
Kolterman, O. G., Gray, R. S., Shapiro, G., Scarlett, J. A., Griffin, J., & Olefsky, J. M. (1984) · Diabetes · doi:10.2337/diab.33.4.346 · Cited by 213
Cited by
DeFronzo, R. A. (2009) · Diabetes · doi:10.2337/db09-9028 · Cited by 3,016
Self-citationIslet cell failure in type 2 diabetes
Prentki, M. (2006) · Journal of Clinical Investigation · doi:10.1172/jci29103 · Cited by 1,690
Pathogenesis of type 2 diabetes mellitus
DeFronzo, R. A. (2004) · Medical Clinics of North America · doi:10.1016/j.mcna.2004.04.013 · Cited by 1,342
Self-citationAbdul-Ghani, M. A., Tripathy, D., & DeFronzo, R. A. (2006) · Diabetes Care · doi:10.2337/dc05-2179 · Cited by 744
Self-citationImpaired Glucose Tolerance as a Disorder of Insulin Action
Lillioja, S., Mott, D. M., Howard, B. V., Bennett, P. H., Yki-Järvinen, H., Freymond, D., Nyomba, B. L., Zurlo, F., Swinburn, B., & Bogardus, C. (1988) · New England Journal of Medicine · doi:10.1056/nejm198805123181901 · Cited by 578
Metadata
- Authors
- Rossetti, L., Shulman, G. I., Zawalich, W., & DeFronzo, R. A.
- Venue
- Journal of Clinical Investigation
- Published
- 1987-10-01
- Volume
- 80
- Issue
- 4
- Pages
- 1037-1044
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W2102348011
- Cited by
- 330
- References
- 4
- FWCI
- 10.13
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Rossetti, L., Shulman, G. I., Zawalich, W., & DeFronzo, R. A. (1987). Effect of chronic hyperglycemia on in vivo insulin secretion in partially pancreatectomized rats. Journal of Clinical Investigation. https://doi.org/10.1172/jci113157
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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