The DOI matches its Crossref record.
Parathyroid hormonelike protein from human renal carcinoma cells. Structural and functional homology with parathyroid hormone.
Open accessAbstract
A variety of solid tumors secrete proteins that are immunochemically distinct from parathyroid hormone (PTH) but activate PTH-responsive adenylate cyclase. Such PTH-like proteins have been proposed as mediators of the hypercalcemia and hypophosphatemia frequently associated with malignancies. We purified to apparent homogeneity a PTH-like protein with a molecular weight of 6,000, that is produced by human renal carcinoma cells. The amino-terminal sequence of the PTH-like protein and that of human PTH were found to display at least five identities in the first 13 positions. The purified protein bound to PTH receptors, activated adenylate cyclase in renal plasma membranes, and stimulated cAMP formation in rat osteosarcoma cells. The PTH-like protein reproduced two additional effects of PTH, stimulation of bone resorption in fetal rat limb bone cultures and inhibition of phosphate uptake in cultured opossum kidney cells. These properties are consistent with a role for PTH-like proteins as mediators of the syndrome of malignancy-associated hypercalcemia.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
Maternal Mineral and Bone Metabolism During Pregnancy, Lactation, and Post-Weaning Recovery
Kovacs, C. S. (2016) · Physiological Reviews · doi:10.1152/physrev.00027.2015 · Cited by 544
Mak, K. K., Bi, Y., Wan, C., Chuang, P.-T., Clemens, T., Young, M., & Yang, Y. (2008) · Developmental Cell · doi:10.1016/j.devcel.2008.02.003 · Cited by 202
Chorev, M., Roubini, E., McKee, R. L., Gibbons, S. W., Goldman, M. E., Caulfield, M. P., & Rosenblatt, M. (1991) · Biochemistry · doi:10.1021/bi00238a022 · Cited by 107
Self-citationEffects of aluminum on the parathyroid hormone receptors of bone and kidney
Pun, K. K., Ho, P. W. M., & Lau, P. (1990) · Kidney International · doi:10.1038/ki.1990.10 · Cited by 18
Metadata
- Authors
- Strewler, G. J., Stern, P. H., Jacobs, J. W., Eveloff, J., Klein, R. F., Leung, S. C., Rosenblatt, M., & Nissenson, R. A.
- Venue
- Journal of Clinical Investigation
- Published
- 1987-12-01
- Volume
- 80
- Issue
- 6
- Pages
- 1803-1807
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W1999856310
- Cited by
- 533
- References
- 0
- FWCI
- 41.27
- Type
- journal article
- Language
- en
- Open access
- bronze
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Parathyroid hormonelike protein from human renal carcinoma cells. Structural and functional homology with parathyroid hormone. https://app.cochat.ai/papers/10.1172/jci113275
- The paper
- Strewler, G. J., Stern, P. H., Jacobs, J. W., Eveloff, J., Klein, R. F., Leung, S. C., Rosenblatt, M., & Nissenson, R. A. (1987). Parathyroid hormonelike protein from human renal carcinoma cells. Structural and functional homology with parathyroid hormone. Journal of Clinical Investigation. https://doi.org/10.1172/jci113275
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
