The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index.
31P nuclear magnetic resonance studies of high energy phosphates and pH in human muscle fatigue. Comparison of aerobic and anaerobic exercise.
Abstract
The goal of these experiments was to investigate the relationship of ATP, phosphocreatine (PCr), inorganic phosphate (Pi), monobasic phosphate (H2PO4-), and pH to human muscle fatigue. Phosphates and pH were measured in adductor pollicis using 31P nuclear magnetic resonance at 2.0 Tesla. The force of muscle contraction was simultaneously measured with a force transducer. The effects of aerobic and anaerobic exercise were compared using two exercise protocols: 4 min sustained maximal voluntary contraction (MVC) and 40 min of repeated intermittent contractions (75% MVC). The sustained maximal contraction produced a rapid decline of MVC and PCr, and was accompanied by a rapid rise of Pi, H+, and H2PO4-. Intermittent exercise produced steady state changes of MVC, pH, and phosphates. No significant changes of ATP were found in either protocol. During fatiguing exercise, PCr and Pi had a nonlinear relationship with MVC. H+ showed a more linear correlation, while H2PO4- showed the best correlation with MVC. Furthermore, the correlations between MVC and H2PO4- were similar in sustained (r = 0.70) and intermittent (r = 0.73) exercise. The highly significant linear relationship between increases of H+ and H2PO4- and the decline of MVC strongly suggests that both H+ and H2PO4- are important determinants of human muscle fatigue.
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“Because of this, prolonged high-intensity exercise results in fatigue, through metabolic, neuromuscular, and mechanical inadequacies (15, 30).”
From Comparison of a Continuous and Discontinuous GXT on VO2 in Resistance-Trained and Endurance-Trained Males (2022) · cites this paper as [30]
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“Highly resistance-trained individuals having a greater anaerobic capacity, may succumb to fatigue through metabolic acidosis before achieving maximal Q (30).”
From Comparison of a Continuous and Discontinuous GXT on VO2 in Resistance-Trained and Endurance-Trained Males (2022) · cites this paper as [30]
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Citations
Cites
Fatigue of long duration in human skeletal muscle after exercise.
Edwards, R. H., Hill, D. K., Jones, D. A., & Merton, P. A. (1977) · The Journal of Physiology · doi:10.1113/jphysiol.1977.sp012072 · Cited by 772
Bioenergetics of intact human muscle. A 31P nuclear magnetic resonance study.
Taylor, D. J., Bore, P. J., Styles, P., Gadian, D. G., & Radda, G. K. (1983) · PubMed · Cited by 510
Muscular fatigue investigated by phosphorus nuclear magnetic resonance
Joan Dawson, M., Gadian, D. G., & Wilkie, D. R. (1978) · Nature · doi:10.1038/274861a0 · Cited by 455
Examination of a Case of Suspected McArdle's Syndrome by31P Nuclear Magnetic Resonance
Ross, B. D., Radda, G. K., Gadian, D. G., Rocker, G., Esiri, M., & Falconer-Smith, J. (1981) · New England Journal of Medicine · doi:10.1056/nejm198105283042206 · Cited by 427
Bigland-Ritchie, B., Jones, D. A., Hosking, G. P., & Edwards, R. H. T. (1978) · Clinical Science · doi:10.1042/cs0540609 · Cited by 424
Energetics of human muscle: Exercise‐induced ATP depletion
Taylor, D. J., Styles, P., Matthews, P. M., Arnold, D. A., Gadian, D. G., Bore, P., & Radda, G. K. (1986) · Magnetic Resonance in Medicine · doi:10.1002/mrm.1910030107 · Cited by 320
Chance, B., Eleff, S., Leigh, J. S., Sokolow, D., & Sapega, A. (1981) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.78.11.6714 · Cited by 318
Bittl, J. A., & Ingwall, J. S. (1985) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)83652-9 · Cited by 291
Bolitho Donaldson, S. K., Hermansen, L., & Bolles, L. (1978) · Pfl�gers Archiv European Journal of Physiology · doi:10.1007/bf00585248 · Cited by 277
The early “pump” failure of the ischemic heart
Katz, A. M., & Hecht, H. H. (1969) · The American Journal of Medicine · doi:10.1016/0002-9343(69)90180-6 · Cited by 243
Cited by
Yquel, R. J., Arsac, L. M., Thiaudiere, E., Canioni, P., & Manier, G. (2002) · Journal of Sports Sciences · doi:10.1080/026404102317366681 · Cited by 94
(2006) · PubMed · Cited by 35
Kraemer, W. J., Gordon, S. E., Lynch, J. M., Pop, M. E. M. V., & Clark, K. L. (1995) · International Journal of Sport Nutrition · doi:10.1123/ijsn.5.4.300 · Cited by 20
(2022) · International Journal of Exercise Science · doi:10.70252/nhay2400 · Cited by 3
Metadata
- Authors
- Miller, R. G., Boska, M. D., Moussavi, R. S., Carson, P. J., & Weiner, M. W.
- Venue
- Journal of Clinical Investigation
- Published
- 1988-04-01
- Volume
- 81
- Issue
- 4
- Pages
- 1190-1196
- ISSN
- 0021-9738
- Cited by
- 136
- References
- 41
- Language
- en
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
