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Platelet-derived growth factor mRNA detection in human atherosclerotic plaques by in situ hybridization.
Open accessAbstract
Platelet-derived growth factor (PDGF) mRNA, and mRNA for its receptor, have been localized to specific cell types within the human atherosclerotic plaque, using in situ hybridization. The predominant cell types found to express PDGF A and B chain mRNA are mesenchymal-appearing intimal cells and endothelial cells, respectively, with little or no expression detected in macrophages. The distribution of PDGF receptor mRNA containing cells was also examined and found to be localized predominantly in the plaque intima.
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Cited by
The Pathogenesis of Coronary Artery Disease and the Acute Coronary Syndromes
Epstein, F. H., Fuster, V., Badimon, L., Badimon, J. J., & Chesebro, J. H. (1992) · New England Journal of Medicine · doi:10.1056/nejm199201233260406 · Cited by 2,717
Chiu, J.-J., & Chien, S. (2011) · Physiological Reviews · doi:10.1152/physrev.00047.2009 · Cited by 2,280
Stary, H. C., Chandler, A. B., Glagov, S., Guyton, J. R., Insull, W., Rosenfeld, M. E., Schaffer, S. A., Schwartz, C. J., Wagner, W. D., & Wissler, R. W. (1994) · Circulation · doi:10.1161/01.cir.89.5.2462 · Cited by 1,312
PLATELET-DERIVED GROWTH FACTOR
Ross, R. (1989) · The Lancet · doi:10.1016/s0140-6736(89)92760-8 · Cited by 940
Role of Smooth Muscle Cells in the Initiation and Early Progression of Atherosclerosis
Doran, A. C., Meller, N., & McNamara, C. A. (2008) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atvbaha.107.159327 · Cited by 804
Metadata
- Authors
- Wilcox, J. N., Smith, K. M., Williams, L. T., Schwartz, S. M., & Gordon, D.
- Venue
- Journal of Clinical Investigation
- Published
- 1988-09-01
- Volume
- 82
- Issue
- 3
- Pages
- 1134-1143
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W2053806341
- Cited by
- 479
- References
- 0
- FWCI
- 14.25
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Wilcox, J. N., Smith, K. M., Williams, L. T., Schwartz, S. M., & Gordon, D. (1988). Platelet-derived growth factor mRNA detection in human atherosclerotic plaques by in situ hybridization. Journal of Clinical Investigation. https://doi.org/10.1172/jci113671
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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