The DOI matches its Crossref record; 42 of the 43 references it cites were found in a registry or an index; none of the 16 sources its claims cite is checked for support yet.
Role of tumor necrosis factor-alpha in the pathophysiologic alterations after hepatic ischemia/reperfusion injury in the rat.
Open accessAbstract
Cytokines are recognized as critical early mediators of organ injury. We attempted to determine whether or not severe hepatic ischemia/reperfusion injury results in tumor necrosis factor-alpha (TNF-alpha) release with subsequent local and systemic tissue injury. After 90 min of lobar hepatic ischemia, TNF was measurable during the reperfusion period in the plasma of all 14 experimental animals, with levels peaking between 9 and 352 pg/ml. Endotoxin was undetectable in the plasma of these animals. Pulmonary injury, as evidenced by a neutrophilic infiltrate, edema and intra-alveolar hemorrhage developed after hepatic reperfusion. The neutrophilic infiltrate was quantitated using a myeloperoxidase (MPO) assay; this demonstrated a significant increase in MPO after only 1 h of reperfusion. Anti-TNF antiserum pretreatment significantly reduced the pulmonary MPO after hepatic reperfusion. After a 12-h reperfusion period, there was histologic evidence of intra-alveolar hemorrhage and pulmonary edema. Morphometric assessment showed that pretreatment with anti-TNF antiserum was able to completely inhibit the development of pulmonary edema. Liver injury was quantitated by measuring serum glutamic pyruvic transaminase which showed peaks at 3 and 24 h. Anti-TNF antiserum pretreatment was able to significantly reduce both of these peak elevations. These data show that hepatic ischemia/reperfusion results in TNF production, and that this TNF is intimately associated with pulmonary and hepatic injury.
Overview
AI snapshot
Written from the paper’s full text.
TL;DR
In a rat model of 90-minute lobar hepatic ischemia/reperfusion, TNF became measurable in plasma in all 14 experimental animals and was associated with subsequent pulmonary and hepatic injury. Pretreatment with anti-TNF antiserum reduced pulmonary neutrophil sequestration, abolished pulmonary edema, and lowered serum SGPT elevations after reperfusion.
Key findings
- After hepatic ischemia/reperfusion, TNF was measurable in plasma of all 14 experimental animals, with a mean peak level of 69.4±30.3 pg/ml and a range of 9–352 pg/ml; TNF was undetectable in sham-operated controls, and endotoxin was undetectable (<5 pg/ml).
- Pulmonary neutrophil sequestration, measured by MPO, peaked after 1 h of reperfusion at 0.653±0.089 U versus 0.213±0.034 U in sham animals (P<0.005). Anti-TNF antiserum reduced MPO to 0.458±0.057 U compared with 0.701±0.040 U in control-serum animals (P<0.005), though it did not return values to sham baseline.
- After 12 h of reperfusion, control-serum animals had 20±4 flooded alveoli/high-power field, whereas anti-TNF antiserum-treated animals had 0±0 (P<0.05 by Wilcoxon rank-sum test).
- Serum SGPT peaked at 3 and 24 h after reperfusion; anti-TNF antiserum significantly reduced both peak elevations (P<0.05 at 3 h and P<0.005 at 24 h versus untreated and control-serum groups). Twenty-four-hour survival was 67% in untreated animals, 92% with anti-TNF antiserum, and 60% with control serum, but the differences were not statistically significant.
Methods
- Adult male pathogen-free Sprague-Dawley rats (200–300 g) underwent 90 min of lobar hepatic ischemia using a Heifitz clip, with sham-operated controls treated identically except for vascular occlusion.
- Plasma TNF activity was measured with a WEHI 164 subclone 13 bioassay; positive samples were confirmed by neutralization with polyclonal rabbit anti-murine TNF antiserum. Endotoxin was measured by a perchloric acid-modified chromogenic limulus assay.
- Organ injury was assessed by pulmonary MPO assay, blinded histologic morphometry of edema-filled alveoli, and serum SGPT. Anti-TNF effects were tested by pretreating rats with polyclonal rabbit anti-murine TNF antiserum versus control rabbit serum. Statistical comparisons used Student Newman-Keuls or Wilcoxon rank-sum tests when data were not normally distributed.
Limitations
- The paper states that 24-h survival differences were not statistically significant, most likely because of relatively small group sizes.
- The paper states that further studies are needed to document the degree to which the observed pulmonary pathology is neutrophil dependent.
- The paper states that the mechanism of TNF induction after hepatic ischemia/reperfusion is not completely clear; the text infers Kupffer cell production/leakage but does not directly establish the cellular source.
- Evident from the text: anti-TNF antiserum did not prevent the transient hypotension after revascularization, so the protective effects observed were not attributable to hemodynamic stabilization.
Model-written summary. Check it against the paper before relying on it.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
0 of 16 cited sources checked · 0 supported · 0 flagged
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“After 90 min of lobar hepatic ischemia, TNF was measurable during the reperfusion period in the plasma of all 14 experimental animals, with levels peaking between 9 and 352 pg/ml.”
- Also stated in: § Results · plain
“TNF was measurable in the plasma of all 14 experimental animals”
§ Role of Tumor Necrosis Factor-a in the Pathophysiologic Alterations after Hepatic Ischemia/Reperfusion Injury in the Rat > Abstract
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passes- Also stated in: § Results · plain
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Endotoxin was undetectable in the plasma of these animals.”
- Also stated in: § Results · plain
“In addition, endotoxin was unde- tectable (< 5 pg/ml).”
§ Role of Tumor Necrosis Factor-a in the Pathophysiologic Alterations after Hepatic Ischemia/Reperfusion Injury in the Rat > Abstract
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passes- Also stated in: § Results · plain
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“TNF was un- detectable at any time point in the three sham-operated con- trol animals”
§ Role of Tumor Necrosis Factor-a in the Pathophysiologic Alterations after Hepatic Ischemia/Reperfusion Injury in the Rat > Results
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesA result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“The neutrophilic infiltrate was quantitated using a myeloperoxidase (MPO) assay; this demonstrated a significant increase in MPO after only 1 h of reperfusion.”
- Also stated in: § Results · plain
“1 h postrevascularization, mean pulmonary MPO was 0.653±0.089U as compared with 0.213±0.034U for sham-operated animals (P < 0.005; Fig. 3.).”
§ Role of Tumor Necrosis Factor-a in the Pathophysiologic Alterations after Hepatic Ischemia/Reperfusion Injury in the Rat > Abstract
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passes- Also stated in: § Results · plain
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Pulmonary injury, as evidenced by a neutrophilic infiltrate, edema and intra-alveolar hemorrhage developed after hepatic reperfusion.”
§ Role of Tumor Necrosis Factor-a in the Pathophysiologic Alterations after Hepatic Ischemia/Reperfusion Injury in the Rat > Abstract
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesA result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“and that a picture of pulmonary neutrophil sequestration and hemorrhagic edema develops.”
§ Role of Tumor Necrosis Factor-a in the Pathophysiologic Alterations after Hepatic Ischemia/Reperfusion Injury in the Rat > Discussion
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesA result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“of 12 animals treated with anti-TNF antiserum before the induction of hepatic ischemia, 11 animals survived for 24 h, giving a 24-h survival of 92%.”
§ Role of Tumor Necrosis Factor-a in the Pathophysiologic Alterations after Hepatic Ischemia/Reperfusion Injury in the Rat > .)
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesA result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“For animals undergoing hepatic ischemia and reperfusion alone, the mean minimum systolic blood was significantly different from sham-operated an- imals (P < 0.005).”
§ Role of Tumor Necrosis Factor-a in the Pathophysiologic Alterations after Hepatic Ischemia/Reperfusion Injury in the Rat > Results
Strength:plain· not yet calibratedCausal:direct· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passesA result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Of 24 animals undergoing 90 min of lobar hepatic ischemia and 24 h of reperfusion, eight animals ex- pired before 24 h, resulting in a 24-h survival of 67%.”
§ Role of Tumor Necrosis Factor-a in the Pathophysiologic Alterations after Hepatic Ischemia/Reperfusion Injury in the Rat > .)
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesA result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“This was not the result of protection from a hypotensive effect, since the anti-TNF and control serum groups showed the same degree of transient hypotension after clamp release.”
§ Role of Tumor Necrosis Factor-a in the Pathophysiologic Alterations after Hepatic Ischemia/Reperfusion Injury in the Rat > Discussion
Load-bearingStrength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passes
- It may state two separate claims as one. 17
- The quote only partly states this claim. 3
- Probably not a substantial claim. 7
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“The mean peak TNF level was 69.4±30.3pg/ml with a range of 9-352 pg/ml.”
§ Role of Tumor Necrosis Factor-a in the Pathophysiologic Alterations after Hepatic Ischemia/Reperfusion Injury in the Rat > Results
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Thus, anti-TNF treatment blunted the increase in pulmonary MPO but did not reduce the MPO level to that observed in sham-operated controls.”
§ Role of Tumor Necrosis Factor-a in the Pathophysiologic Alterations after Hepatic Ischemia/Reperfusion Injury in the Rat > Results
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“MPO levels were maximal after 1 h of reperfusion and gradually decreased over the next 11 h.”
§ Role of Tumor Necrosis Factor-a in the Pathophysiologic Alterations after Hepatic Ischemia/Reperfusion Injury in the Rat > Results
Tests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passesIt may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“24 h survival in animals treated with control serum was similar to that seen in the untreated experimental group with 6 of 10 animals surviving for 24 h.”
§ Role of Tumor Necrosis Factor-a in the Pathophysiologic Alterations after Hepatic Ischemia/Reperfusion Injury in the Rat > .)
Strength:plain· not yet calibratedn = 10Tests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passesIt may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“the anti-TNF-treated rats illustrate essentially normal histology.”
§ Role of Tumor Necrosis Factor-a in the Pathophysiologic Alterations after Hepatic Ischemia/Reperfusion Injury in the Rat > Discussion
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesThe quote only partly states this claim.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Anti-TNF antiserum pretreatment was able to significantly reduce both of these peak elevations.”
- Also stated in: § Results · plain
“SGPT levels were significantly decreased both 3 and 24 h postrevascularization in the animals treated with anti-TNF antiserum as compared to untreated experimental animals and animals treated with control serum (P < 0.05 after 3 h of reperfusion and”
§ Role of Tumor Necrosis Factor-a in the Pathophysiologic Alterations after Hepatic Ischemia/Reperfusion Injury in the Rat > Abstract
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
- Also stated in: § Results · plain
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Statistical significance was not achieved between any of the groups, most likely due to the relatively small numbers in the groups.”
§ Role of Tumor Necrosis Factor-a in the Pathophysiologic Alterations after Hepatic Ischemia/Reperfusion Injury in the Rat > .)
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“After 3 h of hepatic reperfusion, there was a significant decrease in SGPT in animals pretreated with anti-TNF antiserum as compared with both the untreated ex- perimental animals and the control serum-treated animals.”
- Also stated in: § Discussion · hedged
“Animals treated with anti-TNF antiserum showed a significant reduction in a hepatocyte-specific enzyme (SGPT) after hepatic ischemia/reperfusion in comparison to controls treated with control serum”
§ Role of Tumor Necrosis Factor-a in the Pathophysiologic Alterations after Hepatic Ischemia/Reperfusion Injury in the Rat > Discussion
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesThe quote only partly states this claim.
- Also stated in: § Discussion · hedged
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Anti-TNF antiserum pretreatment significantly reduced the pulmonary MPO after hepatic reperfusion.”
§ Role of Tumor Necrosis Factor-a in the Pathophysiologic Alterations after Hepatic Ischemia/Reperfusion Injury in the Rat > Abstract
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesThe quote only partly states this claim.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“the operated rats show intra-alveolar hemorrhage and some edema fluid.”
§ Role of Tumor Necrosis Factor-a in the Pathophysiologic Alterations after Hepatic Ischemia/Reperfusion Injury in the Rat > Discussion
Load-bearingStrength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
In the paper
“Recent clinical data have shown that impaired hepatic function greatly influences severity and impedes reso- lution of ARDS (4).”
§ Role of Tumor Necrosis Factor-a in the Pathophysiologic Alterations after Hepatic Ischemia/Reperfusion Injury in the Rat > Introduction
What the sources say
- Not checked yetcites [4]
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesProbably not a substantial claim. It may state two separate claims as one.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Since the pulmonary circulation represents the first vascu- lar bed into which these cytokines are delivered, the pulmonary parenchyma would be likely to manifest the toxic effects of these cytokines.”
§ Role of Tumor Necrosis Factor-a in the Pathophysiologic Alterations after Hepatic Ischemia/Reperfusion Injury in the Rat > Introduction
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
- Rests on an assumption: The pulmonary circulation is the first vascular bed into which cytokines from injured liver are delivered.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“The lower limit of endotoxin detection in this assay is 5 pg/ml.”
§ Role of Tumor Necrosis Factor-a in the Pathophysiologic Alterations after Hepatic Ischemia/Reperfusion Injury in the Rat > Methods
Strength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✗ Load-bearing: fails✓ Based: passesProbably not a substantial claim. The paper’s conclusions may not depend on it.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“The TNF release also did not appear directly related to the hypotensive effect produced by the I/R process, since anti-TNF antiserum treatment blocked the observed pathology, but did not alter the hypotension following clamp release.”
§ Role of Tumor Necrosis Factor-a in the Pathophysiologic Alterations after Hepatic Ischemia/Reperfusion Injury in the Rat > Discussion
Load-bearingStrength:hedged· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
In the paper
“primary nonfunction of the graft after liver transplantation is also associated with the rapid development ofpulmonary insufficiency (5).”
§ Role of Tumor Necrosis Factor-a in the Pathophysiologic Alterations after Hepatic Ischemia/Reperfusion Injury in the Rat > Introduction
What the sources say
- Not checked yetcites [5]
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesProbably not a substantial claim.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“The pulmonary pathology appears to be a consequence of TNF, since pretreatment with neutralizing anti-TNF anti- serum blunted the neutrophilic infiltrate (as measured by MPO) and completely abolished both the diffuse edema and patchy hemorrhage.”
§ Role of Tumor Necrosis Factor-a in the Pathophysiologic Alterations after Hepatic Ischemia/Reperfusion Injury in the Rat > Discussion
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“Slides were examined in a blinded manner.”
§ Role of Tumor Necrosis Factor-a in the Pathophysiologic Alterations after Hepatic Ischemia/Reperfusion Injury in the Rat > Myeloperoxidase (MPO) assay. Pulmonary neutrophil sequestra- tion was quantitated with the MPO assay (I14).
Strength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✗ Load-bearing: fails✓ Based: passesProbably not a substantial claim. The paper’s conclusions may not depend on it.
In the paper
“Previous in vitro studies have docu- mented the ability of Kupffer cells to produce TNF (28).”
§ Role of Tumor Necrosis Factor-a in the Pathophysiologic Alterations after Hepatic Ischemia/Reperfusion Injury in the Rat > Discussion
What the sources say
- Not checked yetcites [28]
Strength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✗ Load-bearing: fails✓ Based: passesProbably not a substantial claim. The paper’s conclusions may not depend on it.
In the paper
“This antiserum neutralizes both natural and recombinant TNF, cross-reacts with rat TNF and has no cross-reactivity with interleukin 1.”
§ Role of Tumor Necrosis Factor-a in the Pathophysiologic Alterations after Hepatic Ischemia/Reperfusion Injury in the Rat > Methods
What the sources say
- Not checked yetcites 1 1, 12
Load-bearingStrength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
In the paper
“Previous studies have documented a deleterious effect of TNF on the hepatocyte where infused rTNF results in focal hepatic necrosis, as does LPS infusion, and the latter finding could be blocked with anti-TNF antiserum (13).”
§ Role of Tumor Necrosis Factor-a in the Pathophysiologic Alterations after Hepatic Ischemia/Reperfusion Injury in the Rat > Discussion
What the sources say
- Not checked yetcites [13]
Strength:boosted· not yet calibratedCausal:direct· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✗ Load-bearing: fails✓ Based: passesProbably not a substantial claim. The paper’s conclusions may not depend on it. It may state two separate claims as one.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“However, our model was specifically chosen to avoid such vascular con- gestion, involving only lobar vascular occlusion with unim- peded portal flow to the right lobe.”
§ Role of Tumor Necrosis Factor-a in the Pathophysiologic Alterations after Hepatic Ischemia/Reperfusion Injury in the Rat > Discussion
Load-bearingStrength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
The paper states this without a source or data behind it here, so there is nothing to check it against. The quote shows it is in the paper.
In the paper
“The three caudal lobes retain an intact portal inflow and venous out- flow, preventing intestinal venous congestion and possible leakage of bacteria or bacterial products into the circulation.”
§ Role of Tumor Necrosis Factor-a in the Pathophysiologic Alterations after Hepatic Ischemia/Reperfusion Injury in the Rat > Methods
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
In the paper
“These data confirm our earlier study which used an intravenous ra- dioactive tracer to document protein leakage into the lungs (9).”
§ Role of Tumor Necrosis Factor-a in the Pathophysiologic Alterations after Hepatic Ischemia/Reperfusion Injury in the Rat > Results
What the sources say
- Not checked yetcites [9]
Strength:plain· not yet calibratedn = 5Tests✓ Asserted: passes✓ Checkable: passes✗ Load-bearing: fails✓ Based: passesProbably not a substantial claim. The paper’s conclusions may not depend on it.
In the paper
“By utilizing a rat model of lobar, rather than total, hepatic ischemia, a severe ischemic insult was produced without in- ducing mesenteric venous hypertension (8).”
§ Role of Tumor Necrosis Factor-a in the Pathophysiologic Alterations after Hepatic Ischemia/Reperfusion Injury in the Rat > Methods
What the sources say
- Not checked yetcites [8]
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“and that TNF has both local deleterious effects on the hepatocyte and extensive damaging effects on pulmonary integrity.”
§ Role of Tumor Necrosis Factor-a in the Pathophysiologic Alterations after Hepatic Ischemia/Reperfusion Injury in the Rat > Discussion
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
The paper relies on this without support.
TNF is produced primarily by cells of the monocyte/macrophage lineage.
“TNF is produced primarily by cells of the monocyte/macrophage lineage”
The paper relies on this without support.
The liver Kupffer cell mass is the largest fixed macrophage population in the body.
“the liver Kupffer cell mass is the largest fixed macrophage population in the body.”
The paper relies on this without support.
The pulmonary circulation is the first vascular bed into which cytokines from injured liver are delivered.
“the pulmonary circulation represents the first vascu- lar bed into which these cytokines are delivered”
The paper relies on this without support.
The anti-TNF antiserum used in these experiments neutralizes TNF in vivo and does not have other relevant biological activities that could account for the observed protection.
“pretreatment with neutralizing anti-TNF anti- serum blunted the neutrophilic infiltrate”
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Reperfusion of ischemic tissues stimulates cytokine overproduction (e.g., TNF, IL-1, HMGB1), which contributes to the pathogenesis of resulting tissue damage (42)(43)(44).”
From Physiology and immunology of the cholinergic antiinflammatory pathway (2007) · cites this paper as [43]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
Each contradiction between two passages listed here was confirmed by an independent check.
Hepatocyte-injury claim cites the Limulus-assay reference
MinorThe discussion cites reference 13 for prior findings about TNF, LPS, and hepatic necrosis, but reference 13 describes a method for the Limulus test rather than those findings.
“Previous studies have documented a deleterious effect of TNF on the hepatocyte where infused rTNF results in focal hepatic necrosis, as does LPS infusion, and the latter finding could be blocked with anti-TNF antiserum (13).”
“13. Obayashi, T. 1984. Addition of perchloric acid to blood sam- ples for colorimetric limulus, test using chromogenic substrate: com- parison with conventional procedures and clinical applications. J. Lab. Clin. Med. 104:321-330.”
Allograft-rejection citation points to a parasitic-infection paper
MinorThe text cites reference 24 for TNF in renal allograft rejection, but reference 24 is titled as a study of parasitic infections. The renal allograft rejection paper appears as reference 25.
“renal allograft rejection (24)”
“24. Scuderi, P., K. E. Sterling, K. S. Lam, P. R. Finley, K. J. Ryan, C. G. Ray, E. Peterson, D. J. Slyman, and S. E. Salmon. 1986. Raised serum levels of tumor necrosis factor in parasitic infections. Lancet. 1:1364-1365.”
Citations
Cites
Shock and Tissue Injury Induced by Recombinant Human Cachectin
Tracey, K. J., Beutler, B., Lowry, S. F., Merryweather, J., Wolpe, S., Milsark, I. W., Hariri, R. J., Fahey, T. J., Zentella, A., Albert, J. D., et al. (1986) · Science · doi:10.1126/science.3764421 · Cited by 2,549
Anti-cachectin/TNF monoclonal antibodies prevent septic shock during lethal bacteraemia
Tracey, K. J., Fong, Y., Hesse, D. G., Manogue, K. R., Lee, A. T., Kuo, G. C., Lowry, S. F., & Cerami, A. (1987) · Nature · doi:10.1038/330662a0 · Cited by 2,448
Detection of circulating tumor necrosis factor after endotoxin administration
Michie, H. R., Manogue, K. R., Spriggs, D. R., Revhaug, A., O'Dwyer, S., Dinarello, C. A., Cerami, A., Wolff, S. M., & Wilmore, D. W. (1988) · New England Journal of Medicine · doi:10.1056/nejm198806093182301 · Cited by 1,677
Espevik, T., & Nissen-Meyer, J. (1986) · Journal of Immunological Methods · doi:10.1016/0022-1759(86)90322-4 · Cited by 1,256
Waage, A., Halstensen, A. I., & Espevik, T. (1987) · The Lancet · doi:10.1016/s0140-6736(87)91728-4 · Cited by 1,085
Bevilacqua, M. P., Pober, J. S., Majeau, G. R., Fiers, W. C., Cotran, R. S., & Gimbrone, M. A. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.12.4533 · Cited by 1,059
Gamble, J. R., Harlan, J. M., Klebanoff, S. J., & Vadas, M. A. (1985) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.82.24.8667 · Cited by 1,031
Shalaby, M. R., Aggarwal, B. B., Rinderknecht, E., Svedersky, L. P., Finkle, B. S., & Palladino, M. A. (1985) · The Journal of Immunology · doi:10.4049/jimmunol.135.3.2069 · Cited by 916
Tumor Necrosis Factor and Disease Severity in Children with Falciparum Malaria
Grau, G. E., Taylor, T. E., Molyneux, M. E., Wirima, J. J., VASSALLI, P., Hommel, M., & Lambert, P. (1989) · New England Journal of Medicine · doi:10.1056/nejm198906153202404 · Cited by 839
Stimulation of neutrophils by tumor necrosis factor.
Klebanoff, S. J., Vadas, M. A., Harlan, J. M., Sparks, L., Gamble, J. R., Agosti, J. M., & Waltersdorph, A. M. (1986) · The Journal of Immunology · doi:10.4049/jimmunol.136.11.4220 · Cited by 832
Flagged first, then by citations
1 of the 43 references couldn’t be matched to a known paper.
Research works printed but not linked: 2
- Glantz, S. A. 1987. Primer of Biostatistics. 2nd edition.
- Bevilacqua, M. P., J. S. Pober, G. R. Majeau, W. Fiers, R. S. Cotran, and M. A. Gimbrone. 1986. Recombinant tumor necrosis factor induces procoagulant activity in cultured human vascular endo- thelium. Proc. Natl. Acad. Sci. USA. 83:4533-4537.
Cited by
Sorted by citations
Items 401–500 of 821
Beierle, E. A., Vauthey, J., Moldawer, L. L., et al. (1996) · The American Journal of Surgery · doi:10.1016/s0002-9610(99)80100-7 · Cited by 34
Rat liver ischemia–reperfusion-induced apoptosis and necrosis are decreased by FK506 pretreatment
Crénesse, D., Laurens, M., Heurteaux, C., et al. (2003) · European Journal of Pharmacology · doi:10.1016/s0014-2999(03)01977-0 · Cited by 33
Bromelain Ameliorates Hepatic Microcirculation After Warm Ischemia
Bahde, R., Palmes, D., Minin, E., et al. (2007) · Journal of Surgical Research · doi:10.1016/j.jss.2006.10.004 · Cited by 33
Giri, S., Nieber, K., & Bader, A. (2010) · Expert Opinion on Drug Metabolism & Toxicology · doi:10.1517/17425251003792521 · Cited by 33
“In 1999, [187], the limitations on TVX usage were issued in response to the strong association of TVX usage in 14 cases of hepatotoxicity, including 6 deaths and 4 patients who required liver transplantation [188].”
BackgroundTAURINE ATTENUATES COLD ISCHEMIA-REOXYGENATION INJURY IN RAT LIVER1
Wettstein, M., & ussinger, D. H. (2000) · Transplantation · doi:10.1097/00007890-200006150-00012 · Cited by 33
Totsuka, E., Todo, S., Zhu, Y., Ishizaki, N., Kawashima, Y., Jin, M. B., Urakami, A., Shimamura, T., & Starzl, T. E. (1998) · Journal of the American College of Surgeons · doi:10.1016/s1072-7515(98)00179-3 · Cited by 33
EXPRESSION OF TISSUE FACTOR IN HEPATIC ISCHEMIC-REPERFUSION INJURY OF THE RAT
Kobayashi, Y., Yoshimura, N., Nakamura, K. D., et al. (1998) · Transplantation · doi:10.1097/00007890-199809270-00004 · Cited by 33
Furukawa, Y., Libby, P., Stinn, J. L., et al. (2002) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)64928-0 · Cited by 32
Ikemura, K., Iwamoto, T., & Okuda, M. (2009) · Expert Opinion on Drug Metabolism & Toxicology · doi:10.1517/17425250903008525 · Cited by 32
“Moreover, liver I/R injury was reported to also lead to remote organ injury [16].”
BackgroundBoros, P., Tarcsafalvi, A., Wang, L., et al. (2001) · Transplantation · doi:10.1097/00007890-200109150-00011 · Cited by 32
Ohyama, I., Ohmiya, N., Niwa, Y., et al. (2004) · European Journal of Gastroenterology & Hepatology · doi:10.1097/01.meg.0000108315.52416.bf · Cited by 32
Mortality, endotoxaemia and cytokine expression after intermittent and continuous hepatic ischaemia
Hewitt, G., Halliday, I., McCaigue, M. D., et al. (1995) · British journal of surgery · doi:10.1002/bjs.1800821043 · Cited by 32
Wheeler, M. D., Kono, H., Rusyn, I., Arteel, G. E., McCarty, D. M., Samulski, R. J., & Thurman, R. G. (2000) · Hepatology · doi:10.1053/jhep.2000.19339 · Cited by 31
Wang, M., Sakon, M., Umeshita, K., et al. (2001) · Journal of Hepatology · doi:10.1016/s0168-8278(00)00017-9 · Cited by 32
Chan, K., Lin, C.-J., Lee, P., et al. (2008) · Anesthesia & Analgesia · doi:10.1213/ane.0b013e318181f4e6 · Cited by 31
Maring, J., Klompmaker, I. J., Zwaveling, J. H., et al. (2000) · Liver Transplantation · doi:10.1053/jlts.2000.8311 · Cited by 31
Gomez, D. (2007) · World Journal of Gastroenterology · doi:10.3748/wjg.v13.i5.657 · Cited by 32
Shock and Multiple Organ Failure
Abello, P. A., Buchman, T. G., & Bulkley, G. B. (1994) · Advances in experimental medicine and biology · doi:10.1007/978-1-4615-1833-4_18 · Cited by 31
Spin trap protection from tumor necrosis factor cytotoxicity
Pogrebniak, H. W., Matthews, W. J., Mitchell, J. A., et al. (1991) · Journal of Surgical Research · doi:10.1016/0022-4804(91)90026-i · Cited by 31
Neutrophil-induced lung damage after hepatic ischemia and endotoxemia
McGuire, G. M., Liu, P., & Jaeschke, H. (1996) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(95)02028-4 · Cited by 31
STRATEGIES TO MODULATE THE DELETERIOUS EFFECTS OF ENDOTHELIN IN HEPATIC ISCHEMIA-REPERFUSION1
Peralta, C., Bulbena, O., Bargall, R., Prats, N., Gelp�, E., & Rosell??-Catafau, J. (2000) · Transplantation · doi:10.1097/00007890-200012270-00016 · Cited by 31
Palladini, G., Ferrigno, A., Rizzo, V., et al. (2012) · Toxicologic Pathology · doi:10.1177/0192623312441403 · Cited by 30
“The same was true for TNF-alfa concentration, an index of Kupffer cell activation (Table 1) (Colletti et al. 1990).”
BackgroundYamagami, K., Yamamoto, Y., Kume, M., Ishikawa, Y., Yamaoka, Y., Hiai, H., & Toyokuni, S. (2000) · Antioxidants and Redox Signaling · doi:10.1089/ars.2000.2.1-127 · Cited by 30
“…and intercellular adhesion molecule-1 (ICAM-1) (Yadav et al, 1998), as well as cy tokine networks including tumor necrosis fac tors (TNF-a) (Colletti et al, 1990, 1996) and NF-kB (Hur et al, 1999) in the IR injury of liver However, there has been a paucity of data on the early events of IR…”
Ke, B., Shen, X., GAO, F. G., Busuttil, R. W., & Kupiec‐Weglinski, J. W. (2004) · Human Gene Therapy · doi:10.1089/1043034041361244 · Cited by 30
Urata, K., Brault, A., Rocheleau, B., et al. (2000) · Transplant International · doi:10.1007/s001470050724 · Cited by 30
Promotion of Hepatic Ischemia/Reperfusion Injury by IL-12 is Independent of STAT41
Kato, A., Graul-Layman, A. J., Edwards, M. J., et al. (2002) · Transplantation · doi:10.1097/00007890-200204150-00023 · Cited by 29
Lv, X., Wang, Z., Huang, S., et al. (2011) · International Journal of Medical Sciences · doi:10.7150/ijms.8.353 · Cited by 29
Unconventional RORγt+ T Cells Drive Hepatic Ischemia Reperfusion Injury
Eggenhofer, E., Rovira, J., Sabet-Baktach, M., Gröll, A., Scherer, M. N., Dahlke, M., Farkas, S. A., Loss, M., Koehl, G. E., Lang, S. A., et al. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1202975 · Cited by 30
Yoshimoto, K., Tajima, H., Ohta, T., et al. (2012) · Oncology Reports · doi:10.3892/or.2012.1896 · Cited by 29
“However, this clamping causes ischemia-reperfusion injury (19,41), and ischemia-reperfusion injury elicits endothelial cell injury that can manifest as swelling, detachment from the underlying basement membrane, and compromised barrier function.”
Intermittent Hepatic Pedicle Clamping Reduces Liver and Lung Injury
Kimura, N., Muraoka, R., Horiuchi, T., et al. (1998) · Journal of Surgical Research · doi:10.1006/jsre.1998.5311 · Cited by 29
Zhang, T., Xiu, H., Liu, J., Ma, Y., Xu, K.-Q., & Huang, W. (2017) · International Immunopharmacology · doi:10.1016/j.intimp.2017.08.008 · Cited by 28
Ninomiya, M., Shimada, M., Harada, N., et al. (2004) · British journal of surgery · doi:10.1002/bjs.4401 · Cited by 28
THE PORTOSYSTEMIC SHUNT PROTECTS LIVER AGAINST ISCHEMIC REPERFUSION INJURY1
SANKARY, H. N., Yin, D., Chong, A. S., et al. (1999) · Transplantation · doi:10.1097/00007890-199910150-00010 · Cited by 28
Rabie, M. A., Zaki, H. F., & Sayed, H. M. (2019) · Biochemical Pharmacology · doi:10.1016/j.bcp.2019.08.001 · Cited by 25
Iwasaki, W., Kume, M., Kudo, K., Uchinami, H., Kikuchi, I., Nakagawa, Y., Yoshioka, M., & Yamamoto, Y. (2010) · Shock · doi:10.1097/shk.0b013e3181b2ffd2 · Cited by 27
RORγt+ IL-22-producing NKp46+ cells protect from hepatic ischemia reperfusion injury in mice
Eggenhofer, E., Sabet-Rashedi, M., Lantow, M., et al. (2015) · Journal of Hepatology · doi:10.1016/j.jhep.2015.08.023 · Cited by 27
Detection of alcoholic liver disease
Gordon, H. (2001) · World Journal of Gastroenterology · doi:10.3748/wjg.v7.i3.297 · Cited by 27
El‐Ghoneimi, A., Cursio, R., Schmid‐Alliana, A., et al. (2007) · HPB · doi:10.1080/13651820701272292 · Cited by 27
Hepatic stellate cells reversibly express α-smooth muscle actin during acute hepatic ischemia
Rubbia‐Brandt, L., Mentha, G., Desmoulière, A., Costa, A. M. A., Giostra, E., Molas, G., Enzan, H., & Gabbiani, G. (1997) · Transplantation Proceedings · doi:10.1016/s0041-1345(97)00415-6 · Cited by 28
Flohé, S., Speidel, N., Flach, R., et al. (1998) · Transplant International · doi:10.1007/s001470050110 · Cited by 27
Köken, T., Serteser, M., Kahraman, A., et al. (2003) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2003.10.001 · Cited by 27
Turnbull, A. V., & RIVIER, C. L. (1998) · Endocrinology · doi:10.1210/endo.139.1.5642 · Cited by 27
Calleri, A., Roggio, D., Navarro‐Tableros, V., Stefano, N. D., Pasquino, C., David, E., Frigatti, G., Rigo, F., Antico, F., Caropreso, P., et al. (2020) · Stem Cell Reviews and Reports · doi:10.1007/s12015-020-10078-7 · Cited by 26
Ito, K., Ozasa, H., Yoneya, R., & Horikawa, S. (2002) · Liver International · doi:10.1034/j.1600-0676.2002.01685.x · Cited by 26
Tian, X., Yao, J.-H., Li, Y., et al. (2006) · World Journal of Gastroenterology · doi:10.3748/wjg.v12.i3.388 · Cited by 26
Yang, X. F., Liang, L., Zong, C., Lai, F., Zhu, P., Liu, Y., Jiang, J., Yang, Y., Gao, L., Ye, F., et al. (2015) · Oncotarget · doi:10.18632/oncotarget.6744 · Cited by 26
“Activated KCs are able to secret a series of inflammatory cytokines such as TNF-α, IL-6 and chemokines [26-28].”
BackgroundAttenuation of renal ischemia-reperfusion injury by FR167653 in dogs
Kitada, H., Sugitani, A., Yamamoto, H., et al. (2002) · Surgery · doi:10.1067/msy.2002.124629 · Cited by 26
Kupffer Cell Function in Ischemic and Nonischemic Livers After Hepatic Partial Ischemia/Reperfusion
Nakamitsu, A., Hiyama, E., Imamura, Y., et al. (2001) · Surgery Today · doi:10.1007/s005950170198 · Cited by 26
THE EFFECT OF TISSUE FACTOR PATHWAY INHIBITOR ON HEPATIC ISCHEMIC REPERFUSION INJURY OF THE RAT
Yoshimura, N., Kobayashi, Y., Nakamura, K. D., et al. (1999) · Transplantation · doi:10.1097/00007890-199901150-00007 · Cited by 26
Bianchi, M., Fantuzzi, G., Bertini, R., Perin, L., Salmona, M., & Ghezzi, P. (1993) · Cytokine · doi:10.1016/1043-4666(93)90045-7 · Cited by 26
Reperfusion injury following cold ischemia activates rat liver Kupffer cells.
Rao, P. N., Liu, T., Synder, J. T., et al. (1991) · PubMed · Cited by 26
Apoptosis: A new mechanism of endothelial and Kupffer cell killing
TAKEI, Y., Kawano, S., Nishimura, Y., et al. (1995) · Journal of Gastroenterology and Hepatology · doi:10.1111/j.1440-1746.1995.tb01802.x · Cited by 26
Ito, K., Ozasa, H., & Horikawa, S. (2005) · Liver International · doi:10.1111/j.1478-3231.2005.01102.x · Cited by 25
Selzner, M., Selzner, N., Chen, L., et al. (2009) · Liver Transplantation · doi:10.1002/lt.21864 · Cited by 25
Abbate, M., & Remuzzi, G. (1996) · Renal Failure · doi:10.3109/08860229609052807 · Cited by 25
Hato, S., Urakami, A., Yamano, T., et al. (2001) · European Surgical Research · doi:10.1159/000049707 · Cited by 25
Chiang, C., Hsu, K., Yan, H., et al. (1997) · Journal of Applied Physiology · doi:10.1152/jappl.1997.83.2.583 · Cited by 25
“Similar results were also demonstrated by others in I/R injury of liver (7) and lung (33).”
ResultOtani, Y., Takeyoshi, I., Koibuchi, Y., et al. (2000) · The Journal of Heart and Lung Transplantation · doi:10.1016/s1053-2498(00)00066-8 · Cited by 25
Imose, M., Nagaki, M., Naiki, T., et al. (2003) · Liver International · doi:10.1034/j.1478-3231.2003.00867.x · Cited by 25
In situ detection of oxidative stress in rat hepatocytes
Mochida, S., Masaki, N., Ohta, Y., et al. (1992) · The Journal of Pathology · doi:10.1002/path.1711670114 · Cited by 25
Carrick, J. B., Martins, O., Snider, C. C., et al. (1997) · Journal of Surgical Research · doi:10.1006/jsre.1997.4998 · Cited by 25
Lou, J., Bühler, L. H., Deng, S., et al. (1998) · Hepatology · doi:10.1002/hep.510270326 · Cited by 25
High tidal volume ventilation induces lung injury after hepatic ischemia-reperfusion
Ota, S., Nakamura, K., Yazawa, T., Kawaguchi, Y., Baba, Y., Kitaoka, R., Morimura, N., Goto, T., Yamada, Y., & Kurahashi, K. (2006) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00151.2006 · Cited by 24
“Given that macrophages are known to be able to produce a high amount of TNF- and that the liver contains the largest fixed population of macrophages (Kupffer cells) in the body (7, 9), the liver macrophages are considered to be the source of circulating TNF- .”
BackgroundTolba, R. H., Fet, N., Yonezawa, K., et al. (2014) · European Surgical Research · doi:10.1159/000362411 · Cited by 24
Sheth, H. D., Hafez, T. S., Glantzounis, G., et al. (2010) · Journal of Gastroenterology and Hepatology · doi:10.1111/j.1440-1746.2010.06323.x · Cited by 24
TNF-Dependent Signaling Pathways in Liver Cancer: Promising Targets for Therapeutic Strategies?
Roderburg, C., Gautheron, J., & Luedde, T. (2012) · Digestive Diseases · doi:10.1159/000341700 · Cited by 24
Recent advances in understanding acute respiratory distress syndrome
Wohlrab, P., Kraft, F., Tretter, V. E., Ullrich, R., Markstaller, K., & Klein, K. U. (2018) · F1000Research · doi:10.12688/f1000research.11148.1 · Cited by 26
The protective function of galectin‐9 in liver ischemia and reperfusion injury in mice
Hirao, H., Uchida, Y., Kadono, K., et al. (2015) · Liver Transplantation · doi:10.1002/lt.24159 · Cited by 24
“TNF-a triggers neutrophilattracting CXC chemokines to express adhesion molecules on vascular endothelial cells.(32) Neutrophil adhesion to endothelial cells leads to their transmigration into the liver parenchyma.”
BackgroundTanaka, W., Yamanaka, N., Onishi, M., et al. (2000) · Journal of Gastroenterology · doi:10.1007/s005350050024 · Cited by 24
Shimoda, M., Iwasaki, Y., Sawada, T., et al. (2007) · Pathobiology · doi:10.1159/000101050 · Cited by 24
Flohé, S., Speidel, N., Flach, R., et al. (1998) · Transplant International · doi:10.1111/j.1432-2277.1998.tb00782.x · Cited by 24
“Antibodies to TNFa have proved to be protective in hepatic reperfusion injury [ 2 ].”
BackgroundBachmann, S., Caldwell-Kenkel, J. C., Currin, R. T., et al. (1992) · Springer eBooks · doi:10.1007/978-3-642-77423-2_106 · Cited by 24
The Influence of Microenvironment on Survival of Intraportal Transplanted Islets
Yan, L., Ye, L., Chen, Y., He, S.-Q., Zhang, C., Mao, X., & Li, S.-W. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.849580 · Cited by 24
“In addition, it has been suggested that ischemia reperfusion phenomena may directly trigger the activation of sinusoidal endothelial cells and help trigger nonspecific inflammatory responses (109).”
BackgroundInterleukin-11 protects mouse liver from warm ischemia/reperfusion (WI/Rp) injury
Yu, J., Feng, Z., Tan, L., Pu, L., & Kong, L. (2016) · Clinics and Research in Hepatology and Gastroenterology · doi:10.1016/j.clinre.2015.11.009 · Cited by 24
“[5] Colletti LM, Remick DG, Burtch GD, Kunkel SL, Strieter RM, Campbell DAJ.”
BackgroundHeme oxygenase 1 expression in postischemic reperfusion liver damage: effect of L‐Arginine
Lanteri, R., Acquaviva, R., Giacomo, C. D., et al. (2006) · Microsurgery · doi:10.1002/micr.20206 · Cited by 23
Fernández‐Martínez, E., Morales‐Ríos, M. S., Pérez‐Álvarez, V. M., & Muriel, P. (2001) · Drug Development Research · doi:10.1002/ddr.10022 · Cited by 23
“, 1995], ischemiareperfusion [Colletti et al., 1990], cadmium-induced hepatotoxicity [Kayama et al.”
BackgroundEffect of FR167653 on Small Bowel Ischemia-Reperfusion Injury in Dogs
Takeyoshi, I., Iwanami, K., Ohwada, S., Kawashima, Y., Kawata, K., Aiba, M., Kobayashi, J., Koyama, T., Matsumoto, K., Satoh, S., et al. (1999) · Digestive Diseases and Sciences · doi:10.1023/a:1026633510390 · Cited by 23
“treatment resulted in inhibition of hepatic ischemia± reperfusion injury ( 27 ).”
BackgroundGuo, T., Su, Z., Wang, Q., et al. (2019) · Future Medicinal Chemistry · doi:10.4155/fmc-2018-0432 · Cited by 22
How Machine Perfusion Ameliorates Hepatic Ischaemia Reperfusion Injury
Clarke, G., Mergental, H., Hann, A., Perera, M. T. P. R., Afford, S. C., & Mirza, D. F. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22147523 · Cited by 22
Edaravone prevents lung injury induced by hepatic ischemia–reperfusion
Uchiyama, M., Tojo, K., Yazawa, T., et al. (2014) · Journal of Surgical Research · doi:10.1016/j.jss.2014.11.011 · Cited by 22
Kim, Y.-I., Chung, H.-J., Song, K., et al. (2006) · The American Journal of Surgery · doi:10.1016/j.amjsurg.2005.04.018 · Cited by 22
Endotoxin tolerance protects against local hepatic ischemia/reperfusion injury in the rat
Fernández, E. D., Flohé, S., Siemers, F., et al. (2000) · Journal of Endotoxin Research · doi:10.1179/096805100101532216 · Cited by 22
Ito, M., Ishikawa, Y., Kiguchi, H., et al. (2004) · Journal of Gastroenterology and Hepatology · doi:10.1111/j.1440-1746.2004.03435.x · Cited by 22
Duenschede, F., Westermann, S., Riegler, N., Miesner, I., Erbes, K., Ewald, P., Kircher, A., Schaefer, H., Schneider, J., Schad, A., et al. (2006) · European Surgical Research · doi:10.1159/000096061 · Cited by 22
“demonstrated the influence of glycine on apoptosis in a rat model of mesenteric IRI.The most striking result, however, was the decreased content of TNFα in the affected livers. This result might best explain the protection by glycine. TNFα is known to be one of the key mediators that dramatically influences warm hepat…”
BackgroundSystemic and Liver Cytokine Activation
Enayati, P. G. (1994) · Archives of Surgery · doi:10.1001/archsurg.1994.01420350057006 · Cited by 22
THE MACROPHAGE, TNF, AND OTHER CYTOKINES
Pass, H. I., Mew, D., Pass, H. A., et al. (1995) · Chest Surgery Clinics of North America · doi:10.1016/s1052-3359(25)00673-8 · Cited by 22
Squadrito, F., Altavilla, D., Zingarelli, B., et al. (1993) · Life Sciences · doi:10.1016/0024-3205(93)90753-p · Cited by 22
Bachmann, S., Caldwell-Kenkel, J. C., Currin, R. T., et al. (1992) · Transplant International · doi:10.1111/tri.1992.5.s1.345 · Cited by 22
Urata, K., Brault, A., Rocheleau, B., et al. (2000) · Transplant International · doi:10.1111/j.1432-2277.2000.tb01020.x · Cited by 22
Microbiologic findings in feedlot cattle with acute interstitial pneumonia
Woolums, A. R., Mason, G. L., Hawkins, L. L., Brown, C. C., Williams, S. M., Gould, J. A., Fox, J. J., Sturgeon, S. D., Anderson, J. L., Duggan, F. E., et al. (2004) · American Journal of Veterinary Research · doi:10.2460/ajvr.2004.65.1525 · Cited by 21
Zhu, Q., Li, C., Wang, K., et al. (2017) · Liver Transplantation · doi:10.1002/lt.24735 · Cited by 21
Change in free radical-related substances in plasma following ischemia-reperfusion in rat liver
Iwamoto, A., Egashira, T., Takayama, F., et al. (2002) · Pathophysiology · doi:10.1016/s0928-4680(02)00010-x · Cited by 21
“There have been reports that provide evidence for the generation of tumor necrosis factor during ischemiareperfusion injury of the liver, and endotoxin and cytokines are known inducers of NO generation [26,27].”
BackgroundKnudsen, A. R., Kannerup, A.-S., Grønbæk, H., Hamilton-Dutoit, S. J., Nyengaard, J. R., Funch-Jensen, P. M., & Mortensen, F. V. (2012) · Journal of Surgical Research · doi:10.1016/j.jss.2012.03.036 · Cited by 21
“[33] Colletti LM, Remick DG, Burtch GD, et al.”
BackgroundResultReduction of Liver Ischemia Reperfusion Injury by Silencing of TNF-α Gene with shRNA
Hernandez‐Alejandro, R., Zhang, X., Croome, K. P., Zheng, X., Parfitt, J. R., Chen, D., Jevnikar, A. M., Wall, W. J., Min, W.-P., & Quan, D. (2011) · Journal of Surgical Research · doi:10.1016/j.jss.2011.10.004 · Cited by 21
Suzuki, S., Nakamura, S., Sakaguchi, T., et al. (1998) · Journal of Surgical Research · doi:10.1006/jsre.1998.5419 · Cited by 21
Iwasaki, Y., Tagaya, N., Hattori, Y., et al. (2002) · Journal of Surgical Research · doi:10.1006/jsre.2002.6505 · Cited by 21
Interleukin 18 binding protein ameliorates ischemia/reperfusion–induced hepatic injury in mice
Ouzounidis, N., Giakoustidis, A. E., Poutahidis, T., et al. (2015) · Liver Transplantation · doi:10.1002/lt.24359 · Cited by 20
Pentoxifylline in Liver Ischemia and Reperfusion
Genovés, P., García, D., Cejalvo‐Lapeña, D., et al. (2013) · Journal of Investigative Surgery · doi:10.3109/08941939.2013.835454 · Cited by 20
“significantly higher levels of TNF-α was associated with a murine model after 90 min of liver ischemia and 1 hr of reperfusion [36].”
BackgroundYin, X. Y., Lai, P. B. S., Lee, J. F. Y., et al. (2000) · British journal of surgery · doi:10.1046/j.1365-2168.2000.01574.x · Cited by 20
Metadata
- Authors
- Colletti, L. M., Remick, D. G., Burtch, G. D., Kunkel, S. L., Strieter, R. M., & Campbell, D. A.
- Affiliations
- University of Michigan (US)
- Venue
- Journal of Clinical Investigation
- Published
- 1990-06-01
- Volume
- 85
- Issue
- 6
- Pages
- 1936-1943
- ISSN
- 0021-9738 (ISSN-L)
- PMC
- PMC296661
- OpenAlex
- W2099883737
- Semantic Scholar
- ef00ab3fc75d2591f58ef3691dd24619b03cf25e
- Cited by
- 817
- References
- 43
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 2 · 2023: 5 · 2022: 10 · 2021: 8 · 2020: 5 · 2019: 6 · 2018: 16 · 2017: 12 · 2016: 6 · 2015: 15 · 2014: 12 · 2013: 20 · 2012: 24
- FWCI
- 40.45
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Clinical Investigation (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01hl031237-32)
- National Heart, Lung, and Blood Institute (HL-35276, HL31237, HL 31963, P01HL031963)
- Topics
- Health Sciences › Medicine › Surgery › Organ Transplantation Techniques and Outcomes
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Ischemia and Reperfusion
- Keywords
- TNF-α, hepatic ischemia-reperfusion injury, cytokines, pulmonary edema, intra-alveolar hemorrhage, neutrophil infiltration, myeloperoxidase, liver injury, systemic inflammatory response, endotoxin
- MeSH terms
- Alanine Transaminase, Animals, Hemodynamics, Ischemia, Liver, Liver Diseases, Lung, Peroxidase, Neutrophils, Time Factors, Tumor Necrosis Factor-alpha, Reperfusion Injury, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
A language model drew the claims from the paper on 2026-10-10, under version 3 of the claim definition (model deepseek-v4.1-flash, prompt extract-v3).
A second model labelled each claim on 2026-10-10 (model jev-1.13-20260917, definition revision gold-guideline-v0.2).
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
