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Hyperglycemia normalizes insulin-stimulated skeletal muscle glucose oxidation and storage in noninsulin-dependent diabetes mellitus.
Open accessAbstract
The diminished ability of insulin to promote glucose disposal and storage in muscle has been ascribed to impaired activation of glycogen synthase (GS). It is possible that decreased glucose storage could occur as a consequence of decreased glucose uptake, and that GS is impaired secondarily. Muscle glucose uptake in 15 diabetic subjects was matched to 15 nondiabetic subjects by maintaining fasting hyperglycemia during infusion of insulin. Leg muscle glucose uptake, glucose oxidation (local indirect calorimetry), release of glycolytic products, and muscle glucose storage, as well as muscle GS and pyruvate dehydrogenase (PDH) were determined before and during insulin infusion. Basal leg glucose oxidation and PDH were increased in the diabetics. Insulin-stimulated leg glucose uptake in the diabetics (8.05 +/- 1.41 mumol/[min.100 ml leg tissue]) did not differ from controls (5.64 +/- 0.37). Insulin-stimulated leg glucose oxidation, nonoxidized glycolysis, and glucose storage (2.48 +/- 0.27, 0.68 +/- 0.15, and 5.04 +/- 1.34 mumol/[min.100 ml], respectively) were not different from controls (2.18 +/- 0.12, 0.62 +/- 0.16, and 2.83 +/- 0.31). PDH and GS in noninsulin-dependent diabetes mellitus (NIDDM) were also normal during insulin infusion. When diabetics were restudied after being rendered euglycemic by overnight insulin infusion, GS and PDH were reduced compared with hyperglycemia. Thus, fasting hyperglycemia is sufficient to normalize insulin-stimulated muscle glucose uptake in NIDDM, and glucose is distributed normally to glycogenesis and glucose oxidation, possibly by normalization of GS and PDH.
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“Further support for these findings comes from studies in which glucose disposal rates were matched by increasing the glucose or insulin infusion rates ([27](#r27), [66](#r66)).”
From Metabolic flexibility and insulin resistance (2008) · cites this paper as [27]
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Cites
1 retracted
Insulin Sensitivity and Insulin Binding to Monocytes in Maturity-Onset Diabetes
Defronzo, R., Deibert, D., Hendler, R., Felig, P., & Soman, V. (1979) · Journal of Clinical Investigation · doi:10.1172/jci109394 · Cited by 188
Retracted(1975) · Journal of AOAC INTERNATIONAL · doi:10.1093/jaoac/58.5.1085 · Cited by 20,078
Classification and diagnosis of diabetes mellitus and other categories of glucose intolerance.
National Diabetes Data Group (1979) · Diabetes · doi:10.2337/diab.28.12.1039 · Cited by 4,909
(1966) · Food and Cosmetics Toxicology · doi:10.1016/s0015-6264(66)80573-4 · Cited by 4,296
Coated Charcoal Immunoassay of Insulin
Herbert, V. D., Lau, K., Gottlieb, C. W., & Bleicher, S. J. (1965) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-25-10-1375 · Cited by 2,969
Calculation of substrate oxidation rates in vivo from gaseous exchange.
Frayn, K. N. (1983) · Journal of Applied Physiology · doi:10.1152/jappl.1983.55.2.628 · Cited by 2,365
DeFronzo, R. A., Jacot, E., Jequier, E., Maeder, E., Wahren, J., & Felber, J. P. (1981) · Diabetes · doi:10.2337/diab.30.12.1000 · Cited by 1,770
Shulman, G. I., Rothman, D. L., Jue, T., Stein, P., DeFronzo, R. A., & Shulman, R. G. (1990) · New England Journal of Medicine · doi:10.1056/nejm199001253220403 · Cited by 1,248
Effect of fatty acids on glucose production and utilization in man.
Ferrannini, E., Barrett, E. J., Bevilacqua, S., & DeFronzo, R. A. (1983) · Journal of Clinical Investigation · doi:10.1172/jci111133 · Cited by 1,050
Kolterman, O., Gray, R. S., Griffin, J., BURSTEIN, P. J., Insel, J. R., Scarlett, J. A., & Olefsky, J. M. (1981) · Journal of Clinical Investigation · doi:10.1172/jci110350 · Cited by 628
Cited by
Sorted by citations
Items 101–200 of 208
Comparison of type 1, type 2, and atypical ketosis-prone diabetes at 4 years of diabetes duration
Ramos-Román, M. A., Pinero-Pilona, A., ADAMS-HUET, B. A., & Raskin, P. (2006) · Journal of Diabetes and its Complications · doi:10.1016/j.jdiacomp.2006.01.005 · Cited by 32
Glycogen synthase: a putative locus for diet-induced hyperglycemia.
Seldin, M. F., Mott, D. M., Bhat, D., Petro, A., Kuhn, C. M., Kingsmore, S. F., Bogardus, C., Opara, E. C., Feinglos, M. N., & Surwit, R. S. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117317 · Cited by 33
13 C/ 31 P NMR studies of glucose transport in human skeletal muscle
Roussel, R., Carlier, P. G., Robert, J., Velho, G., & Bloch, G. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.3.1313 · Cited by 30
Piatti, P., Monti, L. D., Davis, S. N., Conti, M., Brown, M. D., Pozza, G., & Alberti, K. G. M. M. (1996) · Diabetologia · doi:10.1007/bf00400420 · Cited by 31
Androgens, the Metabolic Syndrome, and Non–Insulin‐Dependent Diabetes Mellitus
Björntorp, P. A. (1993) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1993.tb38738.x · Cited by 28
Buse, J. B., Polonsky, K. S., & Burant, C. (2011) · Elsevier eBooks · doi:10.1016/b978-1-4377-0324-5.00031-6 · Cited by 28
The RNA binding protein HuR influences skeletal muscle metabolic flexibility in rodents and humans
Mynatt, R. L., Noland, R. C., Elks, C. M., Vandanmagsar, B., Bayless, D. S., Stone, A. C., Ghosh, S., Ravussin, É., & Warfel, J. D. (2019) · Metabolism · doi:10.1016/j.metabol.2019.05.010 · Cited by 28
“Classical approaches to describing whole body and skeletal muscle metabolic flexibility have involved measurement of RER changes before and after insulin stimulation[1, 5, 33].”
BackgroundAnti-diabetic potential of Psidium guajava leaf in streptozotocin induced diabetic rats
Tella, T., Masola, B., & Mukaratirwa, S. (2022) · Phytomedicine Plus · doi:10.1016/j.phyplu.2022.100254 · Cited by 36
Wiernsperger, N. F. (2005) · Diabetes & Metabolism · doi:10.1016/s1262-3636(07)70212-4 · Cited by 27
Rissanen, J., Pihlajamäki, J., Heikkinen, S., Kekäläinen, P., Mykkänen, L., Kuusisto, J., Kolle, Å., & Laakso, M. (1997) · Diabetologia · doi:10.1007/s001250050826 · Cited by 26
Effect of lipid oxidation on glucose utilization in humans
Jéquier, E. (1998) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/67.3.527s · Cited by 25
Fechner, E., Bilet, L., Peters, H. P. F., Hiemstra, H., Jacobs, D. M., Eyndt, C. O. ‘., Moonen‐Kornips, E., Mensink, R. P., & Schrauwen, P. (2019) · Clinical Nutrition · doi:10.1016/j.clnu.2019.12.010 · Cited by 27
Poynten, A. M., Markovic, T., Maclean, E., Furler, S. M., Freund, J., Chisholm, D. J., & Campbell, L. V. (2003) · International Journal of Obesity · doi:10.1038/sj.ijo.0802393 · Cited by 26
Hepatic glucose production: therapeutic target in type 2 diabetes?
Stæhr, P., Nielsen, O. H., & Beck‐Nielsen, H. (2002) · Diabetes Obesity and Metabolism · doi:10.1046/j.1463-1326.2002.00177.x · Cited by 25
Fatty acid oxidation in human skeletal muscle
Jensen, M. D. (2002) · Journal of Clinical Investigation · doi:10.1172/jci17303 · Cited by 25
“The present study reports changes in LCFA oxidation and a change in malonyl-CoA levels after 5 hours of significant hyperinsulinemia (insulin concentrations much higher than usually seen in type 2 diabetes) (13).”
BackgroundRasmussen, B. B., Holmbäck, U. C., Volpi, E., Morio, B., Paddon‐Jones, D., & Wolfe, R. R. (2002) · Journal of Clinical Investigation · doi:10.1172/jci200215715 · Cited by 24
Walker, M., Agius, L., Ørskov, H., & Alberti, K. G. M. M. (1993) · Metabolism · doi:10.1016/0026-0495(93)90219-e · Cited by 23
Mechanisms of Insulin Resistance Leading to Hypertension: What We Can Learn from Experimental Models
Sechi, L. A., & Bartoli, E. (1997) · Journal of Investigative Medicine · doi:10.1177/108155899704500503 · Cited by 22
Metabolic flexibility during sleep
Zhang, S., Tanaka, Y., Ishihara, A., Uchizawa, A., Park, I., Iwayama, K., Ogata, H., Yajima, K., Omi, N., Satoh, M., et al. (2021) · Scientific Reports · doi:10.1038/s41598-021-97301-8 · Cited by 21
Zhao, M., Shen, L., Ouyang, Z., Li, M., Deng, G., Yang, C., Zheng, W., Kong, L., Wu, X., Wu, X., et al. (2019) · Journal of Molecular Cell Biology · doi:10.1093/jmcb/mjz050 · Cited by 21
“Reductions in Glu disposal by skeletal muscle appear largely as decreased non-oxidative Glu metabolism, including glycogen synthesis (Kelley and Mandarino, 1990; Hojlund et al., 2003).”
Féry, F., Mélot, C., & BALASSE, E. O. (1993) · Metabolism · doi:10.1016/0026-0495(93)90113-3 · Cited by 21
Contribution of obesity to insulin resistance in noninsulin-dependent diabetes mellitus
Perriello, G., Misericordia, P., Volpi, E., Pampanelli, S., Santeusanio, F., Brunetti, P., & Bolli, G. B. (1995) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.80.8.7629243 · Cited by 21
FDG uptake tracks the oxidative damage in diabetic skeletal muscle: An experimental study
Bauckneht, M., Cossu, V., Castellani, P., Piccioli, P., Orengo, A. M., Emionite, L., Giulio, F. D., Donegani, M. I., Miceli, A., Raffa, S., et al. (2019) · Molecular Metabolism · doi:10.1016/j.molmet.2019.11.007 · Cited by 21
Regulation of Muscle Glucose Uptake In Vivo
Mandarino, L. J., Bonadonna, R. C., McGuinness, O. P., Halseth, A. E., & Wasserman, D. H. (2001) · Comprehensive physiology · doi:10.1002/cphy.cp070227 · Cited by 19
Self-citationAng, J.-H. C., Sun, L., Foo, S.-Y. R., Leow, M. K., Vidal‐Puig, A., Fontana, L., & Dalakoti, M. (2025) · Cell Reports Medicine · doi:10.1016/j.xcrm.2025.102354 · Cited by 23
“…fuel sources to meet energy demands—being central to this adaptability 1,2 Initially thought to be primarily determined by skeletal muscle, 3,4 metabolic flexibility is now recognized as a systemic feature relevant across the whole body, impacting organs, tissues, cells and even organelles.”
Fernández‐Verdejo, R., Castro‐Sepúlveda, M., Gutiérrez‐Pino, J., Malo‐Vintimilla, L., López‐Fuenzalida, A., Olmos, P. R., Santos, J. L., & Galgani, J. E. (2020) · Obesity · doi:10.1002/oby.22783 · Cited by 19
“The RQ after an overnight fast has often been considered a MetFlex marker (6-8).”
BackgroundFatty acid oxidation in human skeletal muscle
Jensen, M. D. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0217303 · Cited by 19
Germani, D., Puglianiello, A., & Cianfarani, S. (2008) · Cardiovascular Diabetology · doi:10.1186/1475-2840-7-14 · Cited by 19
“Insulin resistance and type 2 diabetes are characterized by hyperglycemia with hyperinsulinemia, a reduced ability to oxidize fat, and an accumulation of fat within skeletal muscle [11,12].”
BackgroundJensen, M. D., Nguyen, T. T., Mijares, A. H., Johnson, C. M., & Murray, M. J. (1998) · Journal of Applied Physiology · doi:10.1152/jappl.1998.84.1.141 · Cited by 18
“This question could potentially be addressed by using limb-balance studies; however, most previous studies that examined limb glucose and fat oxidation by using indirect calorimetry have focused primarily (10, 11, 13) or exclusively (8, 9) on men.”
BackgroundGopal, K., Abdualkader, A. M., Li, X., Greenwell, A. A., Karwi, Q. G., Altamimi, T., Saed, C. T., Uddin, G. M., Darwesh, A. M., Jamieson, K. L., et al. (2023) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2023.105375 · Cited by 20
“However, in patients with obesity and type 2 diabetes, muscles become unresponsive to insulin action to increase glucose oxidation (4 – 6).”
BackgroundImpaired glucose partitioning in primary myotubes from severely obese women with type 2 diabetes
Zou, K., Turner, K., Zheng, D., Hinkley, J. M., Kugler, B. A., Hornby, P. J., Lenhard, J. M., Jones, T. E., Pories, W. J., Dohm, G. L., et al. (2020) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00157.2020 · Cited by 17
The Epidemic of Type 2 Diabetes Mellitus: Its Links to Obesity, Insulin Resistance, and Lipotoxicity
Cusi, K. J. (2009) · Humana Press eBooks · doi:10.1007/978-1-59745-260-1_1 · Cited by 15
Soares, R. N., Colosio, A. L., Murias, J. M., & Pogliaghi, S. (2019) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/apnm-2018-0866 · Cited by 17
Metabolic and Molecular Pathogenesis of Type 2 Diabetes Mellitus
DeFronzo, R. A., Mandarino, L. J., & Ferrannini, E. (2003) · Wiley eBooks · doi:10.1002/0470862092.d0310 · Cited by 15
Self-citationWhole Blood Gene Expression Profiles in Insulin Resistant Latinos with the Metabolic Syndrome
Tangen, S. E., Tsinajinnie, D., Nuñez, M., Shaibi, G. Q., Mandarino, L. J., & Coletta, D. K. (2013) · PLoS ONE · doi:10.1371/journal.pone.0084002 · Cited by 15
Self-citationHenry, R. R., Thorburn, A. W., Beerdsen, P., & Gumbiner, B. (1991) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1991.261.1.e132 · Cited by 14
Swislocki, A. (1997) · American Journal of Hypertension · doi:10.1016/s0895-7061(96)00209-9 · Cited by 14
Chronic exercise improves hepatic acylcarnitine handling
Hernández‐Saavedra, D., Hinkley, J. M., Baer, L. A., Pinckard, K. M., Vidal, P., Nirengi, S., Brennan, A. M., Chen, E. Y.-S., Narain, N. R., Bussberg, V., et al. (2024) · iScience · doi:10.1016/j.isci.2024.109083 · Cited by 13
“…Fatty acid trafficking, defined by the ability to regulate lipid mobilization to be used by tissues to fuel fatty acid oxidation, 1,2,40 is largely impaired in patients who are obese or have type 2 diabetes.”
BackgroundLópez, X., Bouché, C., Tatro, E., & Goldfine, A. B. (2008) · Diabetes Obesity and Metabolism · doi:10.1111/j.1463-1326.2008.00913.x · Cited by 14
Peterson, C. M., Zhang, B., Johannsen, D. L., & Ravussin, É. (2017) · International Journal of Obesity · doi:10.1038/ijo.2017.58 · Cited by 15
“Some studies have shown that adjusting MF for the glucose disposal rate (GDR) (9, 11, 25) or measuring MF at matched GDR (8) causes the differences to vanish between lean individuals and individuals with obesity or diabetes, which suggests that metabolic inflexibility stems mostly from lower rates of glucose transport.”
BackgroundInfluentialMetabolic inflexibility in individuals with obesity assessed by near-infrared spectroscopy
Soares, R. N., Reimer, R. A., Doyle–Baker, P. K., & Murias, J. M. (2017) · Diabetes and Vascular Disease Research · doi:10.1177/1479164117725478 · Cited by 12
Mingrone, G., Gaetano, A. D., Av, G., Capristo, E., Benedetti, G., Castagneto, M., & Gasbarrini, G. B. (1999) · Journal of Parenteral and Enteral Nutrition · doi:10.1177/014860719902300280 · Cited by 12
Mostert, M., Rabbone, I., Piccinini, M., Curto, M., Vai, S., Musso, A., & RINAUDO, M. T. (1999) · Journal of Endocrinological Investigation · doi:10.1007/bf03343603 · Cited by 12
Guiducci, L., Liistro, T., Burchielli, S., Panetta, D., Bonora, D., Cecco, P. D., Bucci, M., Moehrs, S., Guerra, A. D., Salvadori, P., et al. (2011) · NMCD. Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2010.11.006 · Cited by 9
Regulation of glycogen synthase in muscle and its role in Type 2 diabetes
Kleinert, M., Sylow, L., & Richter, E. A. (2012) · Diabetes Management · doi:10.2217/dmt.12.54 · Cited by 11
van Breda, E., KEIZER, H. A., Kuipers, H., & van Kranenburg, G. (2003) · British Journal of Sports Medicine · doi:10.1136/bjsm.37.4.345 · Cited by 10
Mingrone, G., Gaetano, A. D., Av, G., Capristo, E., Benedetti, G., Castagneto, M., & Gasbarrini, G. B. (1997) · British Journal Of Nutrition · doi:10.1079/bjn19970190 · Cited by 10
“…is non-insulin-dependent diabetes mellitus (NIDDM), in which the inhibition of the enzyme glycogen synthase (Beck-Nielsen et al. 1992), coupled with a reduced activity of the pyruvate dehydrogenase (EC 1.2.4.1; PDH) complex (Kelley & Mandarino, 1990; Beck-Nielsen et al. 1992) is well recognized.”
InfluentialReview: Adipose tissue: passive sump or active pump?
Perry, C., Sattar, N. A., & Petrie, J. R. (2001) · The British Journal of Diabetes · doi:10.1177/14746514010010020801 · Cited by 10
Insulin Resistance in Essential Hypertension
Hsueh, W. A. (1991) · Springer eBooks · doi:10.1007/978-1-4471-1892-3_5 · Cited by 11
Vestergaard, H., Lund, S. A., Bj�rb�k, C., & Pedersen, O. B. (1995) · Diabetologia · doi:10.1007/bf00422374 · Cited by 9
Fernández‐Verdejo, R., Malo‐Vintimilla, L., Gutiérrez‐Pino, J., López‐Fuenzalida, A., Olmos, P. R., Pablo Irarrázaval, M., & Galgani, J. E. (2021) · Frontiers in Nutrition · doi:10.3389/fnut.2021.745907 · Cited by 7
Schmitz, O., Lund, S. A., Bak, J. F., �rskov, L., Andersen, P. H., M⊘ller, N., Rasmussen, O., Christiansen, J. S., & Pedersen, O. B. (1994) · Acta Diabetologica · doi:10.1007/bf00580757 · Cited by 7
NMR Studies on the Mechanism of Insulin Resistance
Perseghin, G., Petersen, K. F., & Shulman, G. I. (1999) · Humana Press eBooks · doi:10.1007/978-1-59259-716-1_9 · Cited by 7
Galuska, D., Nolte, L. A., Th�rne, A., Kristensen, J. S., Wallberg‐Henriksson, H., & Zierath, J. R. (1994) · Diabetologia · doi:10.1007/s001250050105 · Cited by 7
A review of developments in glycogen synthase kinase-3 regulators over the past 10 years
Wang, Y., Sun, K., Liu, J., Quan, Y., Lu, F.-Z., Quan, Z., Li, X., Shen, Q., & Luan, T. (2025) · Biochemical Pharmacology · doi:10.1016/j.bcp.2025.117204 · Cited by 7
Dotzert, M. S., McDonald, M. W., Olver, T. D., Sammut, M. J., & Melling, C. W. J. (2022) · Journal of Diabetes and its Complications · doi:10.1016/j.jdiacomp.2022.108365 · Cited by 6
Baugh, M. E., Bowser, S. M., McMillan, R. P., Davy, B. M., Essenmacher, L. A., Neilson, A. P., Hulver, M. W., & Davy, K. P. (2020) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00576.2019 · Cited by 6
RINAUDO, M. T., Curto, M., Rabbone, I., Piccinini, M., Bruno, R., Mioletti, S., & Gamba, S. (1994) · Journal of Diabetes and its Complications · doi:10.1016/1056-8727(94)90047-7 · Cited by 6
Rabbone, I., Piccinini, M., Curto, M., Mostert, M., Gamba, S., Mioletti, S., Bruno, R., & RINAUDO, M. T. (1998) · British Journal of Clinical Pharmacology · doi:10.1046/j.1365-2125.1998.00680.x · Cited by 6
Cao, Y., Xu, R., & Zhang, J. (2026) · Frontiers in Pediatrics · doi:10.3389/fped.2026.1679527 · Cited by 5
Barakati, N., Bustos, R. Z., Coletta, D., Langlais, P., Kohler, L., Luo, M., Funk, J., Willis, W., & Mandarino, L. (2022) · Metabolic Syndrome and Related Disorders · doi:10.1089/met.2022.0062 · Cited by 6
“2,3,5 The term metabolic inflexibility has been used to refer to a reduced ability of resting skeletal muscle of insulin-resistant obese and type 2 diabetic patients to appropriately select oxidative fuels, in particular, lipid.”
Self-citationPathogenesis of Type 2 Diabetes
Cusi, K. J., & DeFronzo, R. A. (2001) · Comprehensive physiology · doi:10.1002/cphy.cp070237 · Cited by 5
Barbetti, F. (1996) · Acta Diabetologica · doi:10.1007/bf00571560 · Cited by 4
Barriocanal, L. A., Borthwick, A. C., Stewart, M. W., Wells, A., Hurel, S. J., Yeaman, S. J., & Taylor, R. (1995) · Diabetic Medicine · doi:10.1111/j.1464-5491.1995.tb00429.x · Cited by 4
Yki‐Järvinen, H., & McClain, D. A. (2015) · Wiley eBooks · doi:10.1002/9781118387658.ch27 · Cited by 5
Yki‐Järvinen, H. (2004) · Wiley eBooks · doi:10.1002/0470862092.d0405 · Cited by 4
Diagnosis and Management of Horses with Equine Metabolic Syndrome (EMS)
Chameroy, K. A. (2010) · Cited by 3
Olenick, A., Pearson, R. C., Shaker, N., Blankenship, M. M., Tinius, R. A., Winchester, L. J., Oregon, E., & Maples, J. M. (2022) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph191912913 · Cited by 3
Jéquier, E., & Tappy, L. (1997) · Molecular Aspects of Medicine · doi:10.1016/s0098-2997(97)00045-9 · Cited by 3
Gopal, K., Abdualkader, A. M., Li, X., Greenwell, A. A., Karwi, Q. G., Saed, C. T., Uddin, G. M., Darwesh, A. M., Jamieson, K. L., Altamimi, T., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.05.10.540277 · Cited by 3
Bustos, R. Z., Coletta, D. K., Galons, J., Davidson, L., Langlais, P. R., Funk, J. L., Willis, W. T., & Mandarino, L. J. (2023) · Frontiers in Physiology · doi:10.3389/fphys.2023.1208186 · Cited by 2
Self-citationObesity and the Risk for Diabetes
Gougeon, R. (2001) · Elsevier eBooks · doi:10.1016/b978-012193155-1/50029-5 · Cited by 2
Genetic and Epigenetics of Type 2 Diabetes
Coletta, D. K. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-386456-7.02002-5 · Cited by 2
Subramanian, S. P. (2018) · Journal of Diabetes and Obesity · doi:10.15436/2376-0494.18.1690 · Cited by 2
A NEW METABOLISM MODEL FOR HUMAN SKELETAL MUSCLE
Lv, D., & Goodwine, B. (2008) · Cited by 2
van Breda, E. (1994) · Research Publications (Maastricht University) · doi:10.26481/dis.19940224eb · Cited by 2
Lowe, A. C., Reijnders, D., Tam, C. S., Redman, L. M., Beyl, R. A., LeBlanc, K. A., Hausmann, M. G., Albaugh, V. L., Greenway, F. L., & Ravussin, É. (2024) · Clinical Obesity · doi:10.1111/cob.12726 · Cited by 1
Li, D. F., Morita, K., Kokaji, T., Hatano, A., Hirayama, A., Soga, T., Suzuki, Y., Matsumoto, M., Tsuchiya, T., Ozaki, H., et al. (2026) · npj Systems Biology and Applications · doi:10.1038/s41540-026-00678-3 · Cited by 1
Free Fatty Acids, Insulin Resistance, and Ectopic Fat
Kelley, D. E. (2007) · Humana Press eBooks · doi:10.1007/978-1-59745-400-1_5 · Cited by 1
“Using arteriovenous limb balance methods to assess oxygen and carbon dioxide exchange across the leg, we observed an elevated RQ across the leg after an overnight fast in type 2 DM ( 20 ), which denoted a decreased reliance on fat oxidation.”
MethodSelf-citationWatve, M. (2012) · Springer eBooks · doi:10.1007/978-1-4614-4409-1_2 · Cited by 1
Fatty acid oxidation in human skeletal muscle
Jensen, M. D. (2002) · Journal of Clinical Investigation · doi:10.1172/jci200217303 · Cited by 1
Sikter, A. (2020) · Acta Scientific Medical Sciences · doi:10.31080/asms.2020.04.0553
Shadid, S. (2007) · Research Publications (Maastricht University) · doi:10.26481/dis.20070523ss · Cited by 1
Impaired glycogen synthesis of skeletal muscle in patients with insulin-resistant diabetes mellitus
Pedersen, O. B., Hansen, L., & Bak, J. F. (1994) · Journal of Diabetes and its Complications · doi:10.1016/1056-8727(94)90046-9 · Cited by 1
[Physiopathology of post-prandial hyperglycemia].
Scheen, A. J., & Paquot, N. (2006) · PubMed · Cited by 1
Glucose Metabolism in Low Birth Weight Neonatal Pigs
McCauley, S. R. (2019) · VTechWorks (Virginia Tech) · Cited by 1
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Metadata
- Authors
- Kelley, D. E., & Mandarino, L. J.
- Affiliations
- University of Pittsburgh (US)
- United States Department of Veterans Affairs (US)
- Venue
- Journal of Clinical Investigation
- Published
- 1990-12-01
- Volume
- 86
- Issue
- 6
- Pages
- 1999-2007
- ISSN
- 0021-9738 (ISSN-L)
- PMC
- PMC329837
- OpenAlex
- W2171543951
- Cited by
- 210
- References
- 37
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 3 · 2023: 4 · 2022: 5 · 2021: 4 · 2020: 6 · 2019: 6 · 2018: 4 · 2017: 5 · 2016: 3 · 2015: 5 · 2014: 5 · 2013: 4 · 2012: 8
- FWCI
- 2.85
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Clinical Investigation (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- American Diabetes Association
- Research to Prevent Blindness
- Deutsches Krebsforschungszentrum
- National Institutes of Health (5r01dk041075-03)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01-DK41075)
- National Center for Research Resources (M01RR000056)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Keywords
- hyperglycemia, type 2 diabetes, muscle glucose uptake, glycogen synthase, pyruvate dehydrogenase, insulin resistance, glycogen synthesis, glycolysis
- MeSH terms
- Alanine, Calorimetry, Diabetes Mellitus, Type 2, Glucose, Glycogen Synthase, Glycolysis, Humans, Hyperglycemia, Insulin, Lactates, Leg, Lipid Mobilization, Muscles, Pyruvate Dehydrogenase Complex
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