The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.
Bone morphogenetic protein expression in human atherosclerotic lesions.
Open accessAbstract
Artery wall calcification associated with atherosclerosis frequently contains fully formed bone tissue including marrow. The cellular origin is not known. In this study, bone morphogenetic protein-2a, a potent factor for osteoblastic differentiation, was found to be expressed in calcified human atherosclerotic plaque. In addition, cells cultured from the aortic wall formed calcified nodules similar to those found in bone cell cultures and expressed bone morphogenetic protein-2a with prolonged culture. The predominant cells in these nodules had immunocytochemical features characteristic of microvascular pericytes that are capable of osteoblastic differentiation. Pericyte-like cells were also found by immunohistochemistry in the intima of bovine and human aorta. These findings suggest that arterial calcification is a regulated process similar to bone formation, possibly mediated by pericyte-like cells.
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Osteoprotegerin-deficient mice develop early onset osteoporosis and arterial calcification.
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Bone Formation and Inflammation in Cardiac Valves
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Metadata
- Authors
- Boström, K., Watson, K. E., Horn, S., Wortham, C., Herman, I. M., & Demer, L. L.
- Venue
- Journal of Clinical Investigation
- Published
- 1993-04-01
- Volume
- 91
- Issue
- 4
- Pages
- 1800-1809
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W2147834547
- Cited by
- 1,020
- References
- 22
- FWCI
- 6.56
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Boström, K., Watson, K. E., Horn, S., Wortham, C., Herman, I. M., & Demer, L. L. (1993). Bone morphogenetic protein expression in human atherosclerotic lesions. Journal of Clinical Investigation. https://doi.org/10.1172/jci116391
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
