The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Epstein-Barr virus-infected T lymphocytes in Epstein-Barr virus-associated hemophagocytic syndrome.
Open accessAbstract
The clonal composition of EBV-infected cells was examined in three cases of EBV-associated hemophagocytic syndrome by analysis of the heterogeneity of terminal repetitive sequences in the EBV genome, indicating monoclonal expansion of EBV-infected cells in all cases. Involvement of T lymphoid cells was determined by in situ hybridization using 35S-labeled RNA probes specific for the small EBV-encoded nuclear RNAs, EBER1 and EBER2, in combination with immunostaining for the TCR-beta chain, CD45RO, CD20, CD30 and CD68 antigens in these three cases. The majority of lymphoid cells showing EBER transcripts were stained by antibodies against CD45RO and T cell receptor-beta. In contrast, EBER-specific signals were not detectable on B cells or hemophagocytic cells. These data support the concept that EBV-associated T cell proliferation is a primary feature of EBV-AHS.
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Citations
Cites
Hypercytokinemia in familial hemophagocytic lymphohistiocytosis
Henter, J., Elinder, G., Soder, O., Hansson, M., Andersson, B., & Andersson, U. (1991) · Blood · doi:10.1182/blood.v78.11.2918.2918 · Cited by 505
Cited by
Familial and Acquired Hemophagocytic Lymphohistiocytosis
Janka, G. E. (2012) · Annual Review of Medicine · doi:10.1146/annurev-med-041610-134208 · Cited by 549
INFECTION- AND MALIGNANCY-ASSOCIATED HEMOPHAGOCYTIC SYNDROMES
Janka, G., Imashuku, S., Elinder, G., Schneider, M., & Henter, J.-I. (1998) · Hematology/Oncology Clinics of North America · doi:10.1016/s0889-8588(05)70521-9 · Cited by 455
Imashuku, S., Kuriyama, K., Teramura, T., Ishii, E., Kinugawa, N., Kato, M., Sako, M., & Hibi, S. (2001) · Journal of Clinical Oncology · doi:10.1200/jco.2001.19.10.2665 · Cited by 286
Chellapandian, D., Das, R., Zelley, K., Wiener, S. J., Zhao, H., Teachey, D. T., Nichols, K. E., & EBV‐HLH Rituximab Study Group (2013) · British Journal of Haematology · doi:10.1111/bjh.12386 · Cited by 251
“Epstein–Barr virus (EBV) is a common trigger of HLH, particularly in Asian individuals (Kawaguchi et al, 1993; Imashuku, 2002; Yachie et al, 2003) and in patients with congenital or acquired immunodeficiencies (McClain et al, 1988; Pasic et al, 2003; Rezaei et al, 2011).”
BackgroundHemophagocytic Lymphohistiocytosis in Children: Pathogenesis and Treatment
Ishii, E. (2016) · Frontiers in Pediatrics · doi:10.3389/fped.2016.00047 · Cited by 158
Metadata
- Authors
- Kawaguchi, H., Miyashita, T., Herbst, H., Niedobitek, G., Asada, M., Tsuchida, M., Hanada, R., Kinoshita, A., Sakurai, M., & Kobayashi, N.
- Venue
- Journal of Clinical Investigation
- Published
- 1993-09-01
- Volume
- 92
- Issue
- 3
- Pages
- 1444-1450
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W2151357829
- Cited by
- 206
- References
- 1
- FWCI
- 3.69
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Kawaguchi, H., Miyashita, T., Herbst, H., Niedobitek, G., Asada, M., Tsuchida, M., Hanada, R., Kinoshita, A., Sakurai, M., & Kobayashi, N. (1993). Epstein-Barr virus-infected T lymphocytes in Epstein-Barr virus-associated hemophagocytic syndrome. Journal of Clinical Investigation. https://doi.org/10.1172/jci116721
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