The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.
Antibodies against transforming growth factor-beta 1 suppress intimal hyperplasia in a rat model.
Open accessAbstract
Intimal hyperplasia is induced by therapeutic vascular interventions and often results in clinically important narrowing of the vascular lumen. Examination of the role of TGF-beta 1 in a rat carotid artery injury model confirmed the presence of a previously reported increase in TGF-beta 1 mRNA in the media of injured arteries. Administration of neutralizing anti- TGF-beta 1 antibodies significantly (P < 0.05) reduced the size of the intimal lesions that developed after carotid balloon injury. A control antibody had no effect. The intimal/medial area ratio was also reduced in the anti-TGF-beta 1 group relative to controls (P < 0.01). Immunohistochemical staining showed that two TGF-beta 1-induced extracellular matrix components, EDA + fibronectin and versican, were greatly increased in the untreated neointimal lesions, but were almost completely absent from the lesions of the anti-TGF-beta 1-treated animals. We conclude that TGF-beta 1 is causally involved in the development of intimal hyperplasia, and that anti-TGF-beta 1 agents may be useful in achieving at least partial control of this condition.
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Cites
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Transforming growth factor-beta in disease: the dark side of tissue repair.
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Self-citationInhibition of Neointimal Smooth Muscle Accumulation After Angioplasty by an Antibody to PDGF
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Suppression of experimental glomerulonephritis by antiserum against transforming growth factor β1
Border, W. A., Okuda, S., Languino, L. R., Sporn, M. B., & Ruoslahti, E. (1990) · Nature · doi:10.1038/346371a0 · Cited by 988
Self-citationBorder, W. A., Noble, N. A., Yamamoto, T., Harper, J. R., Yamaguchi, Y., Pierschbacher, M. D., & Ruoslahti, E. (1992) · Nature · doi:10.1038/360361a0 · Cited by 974
Self-citationSato, Y., & Rifkin, D. B. (1989) · The Journal of cell biology · doi:10.1083/jcb.109.1.309 · Cited by 905
Transforming growth factor-beta: recent progress and new challenges.
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Cited by
Transforming growth factor‐β in stem cells and tissue homeostasis
Xu, X., Zheng, L., Yuan, Q., Zhen, G., Crane, J. L., Zhou, X., & Cao, X. (2018) · Bone Research · doi:10.1038/s41413-017-0005-4 · Cited by 414
Metadata
- Authors
- Wolf, Y. G., Rasmussen, L. M., & Ruoslahti, E.
- Venue
- Journal of Clinical Investigation
- Published
- 1994-03-01
- Volume
- 93
- Issue
- 3
- Pages
- 1172-1178
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W2151302132
- Cited by
- 304
- References
- 35
- FWCI
- 6.86
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Wolf, Y. G., Rasmussen, L. M., & Ruoslahti, E. (1994). Antibodies against transforming growth factor-beta 1 suppress intimal hyperplasia in a rat model. Journal of Clinical Investigation. https://doi.org/10.1172/jci117070
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
