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The low density lipoprotein receptor is not required for normal catabolism of Lp(a) in humans.
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Other studies in humans did not find a defect in Lp(a) catabolism for patients with Familial Hypercholesterolemia.
“other studies did not37-39.”
From Functional interrogation of cellular Lp(a) uptake by genome-scale CRISPR screening (2025) · cites this paper as [37]
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Research works printed but not linked: 3
- Utermann, G., F. Hoppichler, H. Dieplinger, M. Seed, G. Thompson, and E. Boerwinkle. 1989. Defects in the low density lipoprotein receptor gene affect lipoprotein (a) levels: multiplicative interaction of two gene loci associated with premature atherosclerosis. Proc. Natl. Acad. Sci. USA. 86:4171-4174.
- Brewer, H. B., Jr. 1990. Effectiveness of diet and drugs in the treatment of patients with elevated Lp(a) levels. In Lipoprotein(a). A. M. Scanu, editor. Academic Press, Inc., New York. 211-220.
- Eaton, D. L., G. M. Fless, W. J. Kohr, J. W. McLean, Q. T. Xu, C. G. Miller, R. M. Lawn, and A. M. Scanu. 1987. Partial amino acid sequence of apolipoprotein(a) shows that it is homologous to plasminogen. Proc. Natl. Acad. Sci. USA. 84:3224-3228.
Cited by
Sorted by citations
Reyes-Soffer, G., Ginsberg, H. N., Berglund, L., Duell, P. B., Heffron, S. P., Kamstrup, P. R., Lloyd-Jones, D. M., Marcovina, S. M., Yeang, C., Koschinsky, M. L., et al. (2022) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atv.0000000000000147 · Cited by 836
Nordestgaard, B. G., & Langsted, A. (2016) · Journal of Lipid Research · doi:10.1194/jlr.r071233 · Cited by 575
Lipoprotein(a): resurrected by genetics
Kronenberg, F., & Utermann, G. (2013) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2012.02592.x · Cited by 521
Effects of PCSK9 inhibition with alirocumab on lipoprotein metabolism in healthy humans
Reyes-Soffer, G., Pavlyha, M., Ngai, C., Thomas, T., Holleran, S., Ramakrishnan, R., Karmally, W., Nandakumar, R., Fontanez, N., Obunike, J., et al. (2017) · Circulation · doi:10.1161/circulationaha.116.025253 · Cited by 240
Thomas, T., Zhou, H., Karmally, W., Ramakrishnan, R., Holleran, S., Liu, Y., Jumes, P., Wagner, J. A., Hubbard, B., Previs, S. F., et al. (2017) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atvbaha.117.309549 · Cited by 96
Self-citationFunctional interrogation of cellular Lp(a) uptake by genome-scale CRISPR screening
Khan, T. G., Bragazzi Cunha, J., Raut, C., Burroughs, M., Vyas, H. S., Leix, K., Goonewardena, S. N., Smrcka, A. V., Speliotes, E. K., & Emmer, B. T. (2025) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2025.119174 · Cited by 6
Metadata
- Authors
- Rader, D. J., Mann, W. A., Cain, W., Kraft, H. G., Usher, D., Zech, L. A., Hoeg, J. M., Davignon, J., Lupien, P., & Grossman, M.
- Venue
- Journal of Clinical Investigation
- Published
- 1995-03-01
- Volume
- 95
- Issue
- 3
- Pages
- 1403-1408
- ISSN
- 0021-9738
- Cited by
- 176
- References
- 0
- Language
- en
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