The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
In vivo angiogenic activity and hypoxia induction of heterodimers of placenta growth factor/vascular endothelial growth factor.
Open accessAbstract
To investigate the in vivo angiogenic activity of placenta growth factor (PIGF) and its heterodimers with vascular endothelial growth factor (VEGF), the induction of neovascularization of these factors in the mouse cornea was studied. VEGF165 is sufficiently potent to stimulate new capillary growth from the limbal vessels. PIGF129/VEGF165 heterodimers also induce corneal neovascularization with a maximal vessel length similar to VEGF165, but with a marked decrease of vessel density. In contrast, PIGF129 has little or no effect in this in vivo angiogenesis assay. The expression of VEGF mRNA and protein is drastically up-regulated by hypoxia in choriocarcinoma cells, whereas expression of PIGF is not affected by the low concentration of oxygen. Up-regulation of VEGF production results in increased formation of PIGF/VEGF heterodimers in these tumor cells. Thus, hypoxia indirectly up-regulates expression levels of PIGF/VEGF heterodimers and modulates VEGF activity when these factors are co-expressed.
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Angiogenesis in cancer, vascular, rheumatoid and other disease
Folkman, J. (1995) · Nature Medicine · doi:10.1038/nm0195-27 · Cited by 7,627
Self-citationVascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis
Shweiki, D., Itin, A., Soffer, D., & Keshet, E. (1992) · Nature · doi:10.1038/359843a0 · Cited by 4,617
Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice
Shalaby, F., Rossant, J., Yamaguchi, T. P., Gertsenstein, M., Wu, X.-F., Breitman, M. L., & Schuh, A. C. (1995) · Nature · doi:10.1038/376062a0 · Cited by 3,931
Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium
Fong, G.-H., Rossant, J., Gertsenstein, M., & Breitman, M. L. (1995) · Nature · doi:10.1038/376066a0 · Cited by 2,606
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Autiero, M., Waltenberger, J., Communi, D., Kranz, A., Moons, L., Lambrechts, D., Kroll, J., Plaisance, S., De Mol, M., Bono, F., et al. (2003) · Nature Medicine · doi:10.1038/nm884 · Cited by 773
Regulation of angiogenesis: Wound healing as a model
EMING, S., BRACHVOGEL, B., ODORISIO, T., & KOCH, M. (2007) · Progress in Histochemistry and Cytochemistry · doi:10.1016/j.proghi.2007.06.001 · Cited by 392
Post stroke depression: the sequelae of cerebral stroke
Das, J., & G.K., R. (2018) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.04.005 · Cited by 301
Griffin, J. B., Lokomba, V., Landis, S. H., Thorp, J. M., Herring, A. H., Tshefu, A. K., Rogerson, S. J., & Meshnick, S. R. (2012) · Malaria Journal · doi:10.1186/1475-2875-11-319 · Cited by 97
Metadata
- Authors
- Cao, Y., Linden, P., Shima, D., Browne, F., & Folkman, J.
- Venue
- Journal of Clinical Investigation
- Published
- 1996-12-01
- Volume
- 98
- Issue
- 11
- Pages
- 2507-2511
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W1990494380
- Cited by
- 211
- References
- 4
- FWCI
- 4.45
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Cao, Y., Linden, P., Shima, D., Browne, F., & Folkman, J. (1996). In vivo angiogenic activity and hypoxia induction of heterodimers of placenta growth factor/vascular endothelial growth factor. Journal of Clinical Investigation. https://doi.org/10.1172/jci119069
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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