The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Identification and localization of polycystin, the PKD1 gene product.
Open accessAbstract
Polycystin, the product of autosomal dominant polycystic kidney disease (ADPKD) 1 gene (PKD1) is the cardinal member of a novel class of proteins. As a first step towards elucidating the function of polycystin and the pathogenesis of ADPKD, three types of information were collected in the current study: the subcellular localization of polycystin, the spatial and temporal distribution of the protein within normal tissues and the effects of ADPKD mutations on the pattern of expression in affected tissues. Antisera directed against a synthetic peptide and two recombinant proteins of different domains of polycystin revealed the presence of an approximately 400-kD protein (polycystin) in the membrane fractions of normal fetal, adult, and ADPKD kidneys. Immunohistological studies localized polycystin to renal tubular epithelia, hepatic bile ductules, and pancreatic ducts, all sites of cystic changes in ADPKD, as well as in tissues such as skin that are not known to be affected in ADPKD. By electron microscopy, polycystin was predominantly associated with plasma membranes. Polycystin was significantly less abundant in adult than in fetal epithelia. In contrast, polycystin was overexpressed in most, but not all, cysts in ADPKD kidneys.
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Cites
Autosomal Dominant Polycystic Kidney Disease—More Than a Renal Disease
Gabow, P. A. (1990) · American Journal of Kidney Diseases · doi:10.1016/s0272-6386(12)80051-5 · Cited by 260
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Self-citationAutosomal dominant polycystic kidney disease
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Metadata
- Authors
- Geng, L., Segal, Y., Peissel, B., Deng, N., Pei, Y., Carone, F., Rennke, H. G., Glücksmann-Kuis, A. M., Schneider, M. C., Ericsson, M., Reeders, S. T., & Zhou, J.
- Venue
- Journal of Clinical Investigation
- Published
- 1996-12-15
- Volume
- 98
- Issue
- 12
- Pages
- 2674-2682
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W2121601246
- Cited by
- 200
- References
- 1
- FWCI
- 7.02
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Geng, L., Segal, Y., Peissel, B., Deng, N., Pei, Y., Carone, F., Rennke, H. G., Glücksmann-Kuis, A. M., Schneider, M. C., Ericsson, M., Reeders, S. T., & Zhou, J. (1996). Identification and localization of polycystin, the PKD1 gene product. Journal of Clinical Investigation. https://doi.org/10.1172/jci119090
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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