Cited by 761Nitric Oxide and Endothelin EffectsDiabetes, Cardiovascular Risks, and LipoproteinsCardiovascular Function and Risk Factors

The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.

Elevated circulating free fatty acid levels impair endothelium-dependent vasodilation

Open access

Steinberg, H O, Tarshoby, M, Monestel, R, Hook, G, Cronin, J, Johnson, A, Bayazeed, B, Baron, A D·1997·Journal of Clinical Investigation

DOI 10.1172/jci119636PMC PMC508300

Open this paper in CoChat — free account Open PDF

Abstract

We have recently shown that insulin-resistant obese subjects exhibit impaired endothelial function. Here, we test the hypothesis that elevation of circulating FFA to levels seen in insulin-resistant subjects can impair endothelial function. We studied leg blood flow responses to graded intrafemoral artery infusions of the endothelium-dependent vasodilator methacholine chloride (Mch) or the endothelium-independent vasodilator sodium nitroprusside during the infusion of saline and after raising systemic circulating FFA levels exogenously via a low- or high-dose infusion of Intralipid plus heparin or endogenously by an infusion of somatostatin (SRIF) to produce insulinopenia in groups of lean healthy humans. After 2 h of infusion of Intralipid plus heparin, FFA levels increased from 562+/-95 to 1,303+/-188 micromol, and from 350+/-35 to 3,850+/-371 micromol (P < 0.001) vs. saline for both low- and high-dose groups, respectively. Mch-induced vasodilation relative to baseline was reduced by approximately 20% in response to the raised FFA levels in both groups (P < 0.05, saline vs. FFA, ANOVA). In contrast, similar FFA elevation did not change leg blood flow responses to sodium nitroprusside. During the 2-h SRIF infusion, insulin levels fell, and FFA levels rose from 474+/-22 to 1,042+/-116 micromol (P < 0.01); Mch-induced vasodilation was reduced by approximately 20% (P < 0.02, saline vs. SRIF, ANOVA). Replacement of basal insulin levels during SRIF resulted in a fall of FFA levels from 545+/-47 to 228+/-61 micromol, and prevented the impairment of Mch-induced vasodilation seen with SRIF alone. In conclusion, (a) elevated circulating FFA levels cause endothelial dysfunction, and (b) impaired endothelial function in insulin-resistant humans may be secondary to the elevated FFA concentrations observed in these patients.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1172/jci119636

Cites

16 of 16 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Obesity/insulin resistance is associated with endothelial dysfunction. Implications for the syndrome of insulin resistance
Steinberg, H. O., Chaker, H., Leaming, R., Johnson, A., Brechtel, G., & Baron, A. D. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118709 · Cited by 1,687 · cited 10×
“We found, however, that serum cholesterol and blood pressure elevations could account for only a small proportion of the endothelial dysfunction displayed in these subjects (4).”
BackgroundResultInfluentialSelf-citation
Insulin-mediated skeletal muscle vasodilation is nitric oxide dependent. A novel action of insulin to increase nitric oxide release.
Steinberg, H. O., Brechtel, G., Johnson, A., Fineberg, N. S., & Baron, A. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117433 · Cited by 1,216
Self-citation
Decreased effect of insulin to stimulate skeletal muscle blood flow in obese man. A novel mechanism for insulin resistance.
Laakso, M., Edelman, S. V., Brechtel, G., & Baron, A. D. (1990) · Journal of Clinical Investigation · doi:10.1172/jci114644 · Cited by 930
Self-citation
Rates and tissue sites of non-insulin- and insulin-mediated glucose uptake in humans
Baron, A., Brechtel, G., Wallace, P., & Edelman, S. V. (1988) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1988.255.6.e769 · Cited by 645
Self-citation
Colorimetric ultramicro method for the determination of free fatty acids
Novák, M. (1965) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)39315-9 · Cited by 639
Impaired Insulin-Mediated Skeletal Muscle Blood Flow in Patients With NIDDM
Laakso, M., Edelman, S. V., Brechtel, G., & Baron, A. D. (1992) · Diabetes · doi:10.2337/diab.41.9.1076 · Cited by 470 · cited 1×
“Interestingly, this insulin effect is either blunted or absent in obese insulin-resistant subjects with or without non-insulin-dependent diabetes mellitus (NIDDM) 1 (1, 3).”
BackgroundSelf-citation
THE VASCULAR BIOLOGY OF NITRIC OXIDE AND ITS ROLE IN ATHEROGENESIS
Lloyd‐Jones, D. M., & Bloch, K. D. (1996) · Annual Review of Medicine · doi:10.1146/annurev.med.47.1.365 · Cited by 243
Syndrome X: 6 years later.
Reaven, G. M. (1994) · PubMed · Cited by 241
Oleic Acid Inhibits Endothelial Nitric Oxide Synthase by a Protein Kinase C–Independent Mechanism
Davda, R. K., Stepniakowski, K. T., Lü, G., Ullian, M. E., Goodfriend, T. L., & Egan, B. M. (1995) · Hypertension · doi:10.1161/01.hyp.26.5.764 · Cited by 216
Impaired insulin-mediated skeletal muscle blood flow in patients with NIDDM
Laakso, M., Edelman, S. V., Brechtel, G., et al. (1992) · Diabetes · doi:10.2337/diabetes.41.9.1076 · Cited by 145

Show all 16 references

Sorted by citations

Items 501–600 of 761

The Role of Adipokines and Gastrointestinal Tract Hormones in Obesity
Świerczyński, J., & Śledziński, T. (2012) · Springer eBooks · doi:10.1007/978-3-642-02411-5_6 · Cited by 12
Mechanistic insight of mitochondrial dysfunctions in cardiovascular diseases with potential biomarkers
Islam, M. N., Mishra, V. K., Munalisa, R., Parveen, F., Ali, S. F., Akter, K., Ahmed, T., Ho, T., & Huang, C. (2024) · Molecular & Cellular Toxicology · doi:10.1007/s13273-023-00424-4 · Cited by 11
Brain Dopamine–Clock Interactions Regulate Cardiometabolic Physiology: Mechanisms of the Observed Cardioprotective Effects of Circadian-Timed Bromocriptine-QR Therapy in Type 2 Diabetes Subjects
Cincotta, A. H. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241713255 · Cited by 11
Oleic acid activates MMPs up-regulation through SIRT1/PPAR-γ inhibition: a probable linkage between obesity and coronary arterial disease
Chan, S., Chu, P., Kao, C.-L., Cheng, Y., Hung, C., & Tsai, K. (2016) · The Journal of Biochemistry · doi:10.1093/jb/mvw028 · Cited by 11
Significance of Plasma Free Fatty Acid Level for Assessing and Diagnosing Acute Myocardial Infarction
Kan, Y., Wang, H., Lu, J., Lin, Z., Lin, J. M., & Gong, P. (2020) · Biomarkers in Medicine · doi:10.2217/bmm-2019-0291 · Cited by 11
Lack of proinflammatory effects of free fatty acids on human umbilical cord vein endothelial cells and leukocytes
Holthe, M. R., Andersson, Y., & Lyberg, T. (2005) · Acta Obstetricia Et Gynecologica Scandinavica · doi:10.1080/j.0001-6349.2005.00799.x · Cited by 11
Acute elevation of triglycerides increases left ventricular contractility and alters ventricular-vascular interaction
Holland, D. J., Erne, D., Kostner, K., Leano, R., Haluska, B. A., Marwick, T. H., & Sharman, J. E. (2011) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00102.2011 · Cited by 11
IGF-I activity may be a key determinant of stroke risk – a cautionary lesson for vegans
McCarty, M. F. (2003) · Medical Hypotheses · doi:10.1016/s0306-9877(02)00241-4 · Cited by 11
Acute elevation of plasma non-esterified fatty acids increases pulse wave velocity and induces peripheral vasodilation in humansin vivo
Riksen, N. P., Bosselaar, M., Bakker, S. J. L., Heine, R. J., Rongen, G. A. P. J. M., Tack, C. J., & Smits, P. (2007) · Clinical Science · doi:10.1042/cs20060365 · Cited by 11
Inpatient Diabetes Control
Bloomgarden, Z. T. (2004) · Diabetes Care · doi:10.2337/diacare.27.9.2272 · Cited by 12
Synergistic association of elevated serum free fatty acid and glucose levels with large arterial stiffness in a general population: The Nagahama Study
Tabara, Y., Takahashi, Y., Setoh, K., Kawaguchi, T., Gotoh, N., Terao, C. C., Yamada, R., Kosugi, S., Sekine, A., Nakayama, T., et al. (2015) · Metabolism · doi:10.1016/j.metabol.2015.10.011 · Cited by 10
Free fatty acids and heart failure in the Multi-Ethnic Study of Atherosclerosis (MESA)
Nomura, S. J. O., Karger, A. B., Weir, N. L., Lima, J. A. C., Thanassoulis, G., & Tsai, M. Y. (2021) · Journal of clinical lipidology · doi:10.1016/j.jacl.2021.05.005 · Cited by 10
Clinacanthus nutans: Its potential against diabetic vascular diseases
Azemi, A. K., Mokhtar, S. S., & Rasool, A. H. G. (2020) · Brazilian Journal of Pharmaceutical Sciences · doi:10.1590/s2175-97902020000118838 · Cited by 11
Effects of acetyl‐L‐carnitine and oxfenicine on aorta stiffness in diabetic rats
Chang, K., Tseng, C., Lu, S., Liang, J., Wu, M., Tsai, M., & Hsu, K. (2010) · European Journal of Clinical Investigation · doi:10.1111/j.1365-2362.2010.02358.x · Cited by 10
Effects of free fatty acids and a triglyceride‐rich fat emulsion on endothelial nitric oxide synthase
Halle, M., Eriksson, P. O., & Tornvall, P. (2005) · European Journal of Clinical Investigation · doi:10.1111/j.1365-2362.2005.01448.x · Cited by 10
Mechanism of lipid enhancement of α1-adrenoceptor pressor sensitivity in hypertension
Gadegbeku, C. A., Shrayyef, M. Z., Taylor, T. P., & Egan, B. M. (2006) · Journal of Hypertension · doi:10.1097/01.hjh.0000234119.63519.5a · Cited by 10
No, the glycaemic target in the critically ill should not be ≤6.1 mmol/l
Miles, J. M., McMahon, M. M., & Isley, W. L. (2007) · Diabetologia · doi:10.1007/s00125-007-0888-5 · Cited by 10
Fisiopatología de la hipertensión arterial secundaria a obesidad
Casilimas, G. A. G., Martin, D. A., Martínez‐Ceballos, M. A., Merchán, C. R., Mayorga, C. A., & Barragán, A. F. (2017) · Archivos de cardiología de México · doi:10.1016/j.acmx.2017.02.001 · Cited by 14
The role of nonesterified fatty acids in pathogenesis of cardiovascular diseases
Tsvetkova, M. V., Хирманов, В. Н., & Zybina, N. N. (2010) · Arterial’naya Gipertenziya (Arterial Hypertension) · doi:10.18705/1607-419x-2010-16-1-93-103 · Cited by 10
Oxidants and Endothelial Dysfunction
Lund, A. K. (2010) · Elsevier eBooks · doi:10.1016/b978-0-08-046884-6.00712-0 · Cited by 12
Review: Adipose tissue: passive sump or active pump?
Perry, C., Sattar, N. A., & Petrie, J. R. (2001) · The British Journal of Diabetes · doi:10.1177/14746514010010020801 · Cited by 10
Internal medicine reformation
Blackwell, T. A., & Powell, D. W. (2004) · The American Journal of Medicine · doi:10.1016/j.amjmed.2004.04.007 · Cited by 10
Chronic consumption of an inositol-enriched beverage ameliorates endothelial dysfunction and oxidative stress in type 2 diabetes
Hernández‐Mijares, A., Bañuls, C., Rovira‐Llopis, S., Álvarez, Á., Orden, S., Rubio-Puchol, O., Víctor, V. M., & Rocha, M. (2015) · Journal of Functional Foods · doi:10.1016/j.jff.2015.08.025 · Cited by 9
Use of fat-fed rats to study the metabolic and vascular sequelae of obesity and beta-adrenergic antagonism.
Frye, M. A., McMurtry, I. F., Orton, E. C., & Fagan, K. (2009) · PubMed Central · Cited by 9
Prediabetes: grounds of pitfall signalling alteration for cardiovascular disease
Goyal, S. N., Haiderali, S., Navya Reddy, M., Arya, D. S., & Patil, C. R. (2014) · RSC Advances · doi:10.1039/c4ra10366a · Cited by 9
Relationship between Cardiovascular Disease Risk and Neck Circumference Shown in the Systematic Coronary Risk Estimation (SCORE) Risk Model
Asıl, S., Murat, E., Taşkan, H., Barış, V. Ö., Görmel, S., Yaşar, S., Çeli̇k, M., Yüksel, U. Ç., Kabul, H. K., & Barçın, C. (2021) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph182010763 · Cited by 9
Relevance of admission hyperglycaemia and diabetes mellitus to efficacy and safety of mechanical thrombectomy in stroke patients
Lasek‐Bal, A., Żak, A., Binek, Ł., Student, S., Cieślik, A., Bal, W., Rybicki, W., & Kulawik-Szwajca, J. (2022) · Neurologia i Neurochirurgia Polska · doi:10.5603/pjnns.a2022.0063 · Cited by 9
Pharmacological characterization of mechanisms involved in the vasorelaxation produced by rosuvastatin in aortic rings from rats with a cafeteria‐style diet
López‐Canales, J. S., Lozano‐Cuenca, J., López-Canales, O. A., Aguilar‐Carrasco, J. C., Aranda‐Zepeda, L., López‐Sánchez, P., Castillo, E. F., López, R. M., & Valencia‐Hernández, I. (2015) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/1440-1681.12406 · Cited by 9
Hyperglycaemia in patients with no history of diabetes presenting to Internal Medicine Departments
Bar‐Dayan, Y., Beer, I., Boaz, M., Landau, Z., Jakubowicz, D. J., & Wainstein, J. (2015) · International Journal of Clinical Practice · doi:10.1111/ijcp.12690 · Cited by 9
Expansion de la masse grasse, acides gras et adipokines : des marqueurs métaboliques et des facteurs de risque de pathologies cardiovasculaires
Lafontan, M. (2012) · Annales Pharmaceutiques Françaises · doi:10.1016/j.pharma.2012.07.008 · Cited by 10
A shift in myocardial substrate, improved endothelial function, and diminished sympathetic activity may contribute to the anti-anginal impact of very-low-fat diets
McCarty, M. F. (2003) · Medical Hypotheses · doi:10.1016/s0306-9877(03)00232-9 · Cited by 9
Acute elevations of medium‐and long‐chain fatty acids have different impacts on endothelium‐dependent vasodilation in humans
Steer, P., Basu, S., Lithell, H., Vessby, B. O., Berne, C., & Lind, L. (2003) · Lipids · doi:10.1007/s11745-003-1025-9 · Cited by 9
Triglycerides and endothelial function in type 2 diabetes
Rongen, G. A. P. J. M., & Tack, C. J. (2001) · European Journal of Clinical Investigation · doi:10.1046/j.1365-2362.2001.00854.x · Cited by 9
Prolonged Local Forearm Hyperinsulinemia Induces Sustained Enhancement of Nitric Oxide–Dependent Vasodilation in Healthy Subjects
Hermann, T. S., Ihlemann, N., Domínguez, H., Rask‐Madsen, C., Køber, L., & Torp-Pedersen, C. T. (2004) · Endothelium · doi:10.1080/10623320490904098 · Cited by 9
Free Fatty Acids, A Major Link Between Obesity, Insulin Resistance, Inflammation, and Atherosclerotic Vascular Disease
Boden, G. H. (2008) · Humana Press eBooks · doi:10.1007/978-1-59745-141-3_4 · Cited by 8
Nitric Oxide, Its Role in Diabetes Mellitus and Methods to Improve Endothelial Function
Nikolaeva, M., & Johnstone, M. T. (2023) · Contemporary cardiology · doi:10.1007/978-3-031-13177-6_7 · Cited by 9
Palmitate Stimulates Expression of the von Willebrand Factor and Modulates Toll-like Receptors Level and Activity in Human Umbilical Vein Endothelial Cells (HUVECs)
Seliga, A. K., Zabłocki, K., & Bandorowicz‐Pikuła, J. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms25010254 · Cited by 9
Neck circumference predicts renal function decline in overweight women
Yoon, C.-Y., Park, J. T., Jhee, J. H., Kee, Y. K., Seo, C., Lee, M., Cha, M.-U., Jung, S.-Y., Park, S., Yun, H., et al. (2016) · Medicine · doi:10.1097/md.0000000000004844 · Cited by 8
Fasting and Post-Load Glucose and Non-Esterified Fatty Acids and Risk of Heart Failure and Its Subtypes in Older Adults
Oesterle, A., Bůžková, P., Pellegrini, C. N., Hirsch, C. H., Tracy, R. P., Siscovick, D. S., Djoussé, L., Mukamal, K. J., & Kizer, J. R. (2022) · The Journals of Gerontology Series A · doi:10.1093/gerona/glac229 · Cited by 8
Common variants associated with changes in levels of circulating free fatty acids after administration of glucose–insulin–potassium (GIK) therapy in the IMMEDIATE trial
Ellis, K. L., Zhou, Y., Rodriguez‐Murillo, L., Beshansky, J. R., Ainehsazan, E., Selker, H. P., Huggins, G. S., Cupples, L. A., & Peter, I. (2015) · The Pharmacogenomics Journal · doi:10.1038/tpj.2015.84 · Cited by 8
Insulin‐mediated vasodilation and glucose uptake are independently related to fasting serum nonesterified fatty acids in elderly men
Andersson, P.-E., Lind, L., Berne, C., Berglund, L., & Lithell, H. (1999) · Journal of Internal Medicine · doi:10.1046/j.1365-2796.1999.00549.x · Cited by 8
Effects of acute hypercholesterolemia on blood pressure and pressor response to norepinephrine in rats
Atarashi, K., Ishiyama, A., Minami, M., Takagi, M., & Omata, M. (2004) · Blood Pressure · doi:10.1080/08037050310028471 · Cited by 8
Insulin Resistance and Hypertension
Shankar, S. S., & Steinberg, H. O. (2012) · Humana Press eBooks · doi:10.1007/978-1-60761-548-4_12 · Cited by 8
Self-citation
Synbiotic control of inflammation and infection in transplantation
Bengmark, S. (2004) · Transplantation Reviews · doi:10.1016/j.trre.2004.01.001 · Cited by 8
Insulin resistance and the regulation of vascular tone: is insulin a vasodilator?
Vischer, U. M. (1998) · European Journal of Endocrinology · doi:10.1530/eje.0.1380262 · Cited by 8
Endothelial Metabolic Reprogramming Links Diabetes to Atherosclerosis
Pan, Y., & Si, J. (2026) · Diabetes Metabolic Syndrome and Obesity · doi:10.2147/dmso.s565805 · Cited by 9
Insulin Resistance and Inflammation
Boden, G. H. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-800093-9.00008-9 · Cited by 7
Postprandial Triglycerides, Oxidative Stress, and Inflammation
Le, N. (2020) · IntechOpen eBooks · doi:10.5772/intechopen.91303 · Cited by 7
Metabonomic approaches investigate diosbulbin B-induced pulmonary toxicity and elucidate its underling mechanism in male mice
Ji, H., Liu, C., Tong, N., Song, N., Xu, B., Zhao, C., Li, H., Shen, G., & Li, H. (2021) · Toxicology Research · doi:10.1093/toxres/tfab014 · Cited by 7
Fat intake impairs the recovery of endothelial function following mental stress in young healthy adults
Baynham, R., Weaver, S. R., Rendeiro, C., & Zanten, J. V. (2023) · Frontiers in Nutrition · doi:10.3389/fnut.2023.1275708 · Cited by 7
Free fatty acids are associated with pulse pressure in women, but not men, with type 1 diabetes mellitus
Conway, B. N., Evans, R. W., Fried, L. F., Kelsey, S. F., Edmundowicz, D., & Orchard, T. J. (2009) · Metabolism · doi:10.1016/j.metabol.2009.03.010 · Cited by 7
Plasma free fatty acids in relation with the severity of coronary artery disease in non-diabetics: A Gensini score assessment
Jin, J., Guo, Y., & Li, J. (2016) · IJC Metabolic & Endocrine · doi:10.1016/j.ijcme.2016.12.004 · Cited by 7
Serum metabolomic response to exercise training in spontaneously hypertensive rats
Liu, X., Wang, Y., Gao, R., Xing, Y., Li, X., & Wang, Z. (2017) · Journal of the American Society of Hypertension · doi:10.1016/j.jash.2017.05.003 · Cited by 7
Obesity-Associated Hypertension
Uwaifo, G. I. (2012) · Humana Press eBooks · doi:10.1007/978-1-60761-548-4_13 · Cited by 7
Differential effects of saturated and unsaturated fatty acids on vascular reactivity in isolated mesenteric and femoral arteries of rats
Vorn, R., & Yoo, H. Y. (2019) · Korean Journal of Physiology and Pharmacology · doi:10.4196/kjpp.2019.23.5.403 · Cited by 7
Lipids enhance α1-adrenoceptor pressor sensitivity in patients with chronic kidney disease
Gadegbeku, C. A., Shrayyef, M. Z., LaPorte, F. B., & Egan, B. M. (2004) · American Journal of Kidney Diseases · doi:10.1053/j.ajkd.2004.05.025 · Cited by 7
Incorporation of beta cell redifferentiation therapy into a lipoprivic strategy for reversing type 2 diabetes
McCarty, M. F. (2002) · Medical Hypotheses · doi:10.1054/mehy.2001.1454 · Cited by 7
Endothelial Function and Mechanical Properties of the Common Carotid Artery in Children on Parenteral Nutrition
Aggoun, Y., Colomb, V., Turanlahti, M., Corriol, O., Goulet, O., Sidi, D., Ricour, C., & Bonnet, D. (2004) · Pediatric Research · doi:10.1203/01.pdr.0000115680.46755.f5 · Cited by 7
Association between insulin resistance and endothelial dysfunction in renal transplant recipients
Voytovich, M. H., Åsberg, A., Hjelmesaeth, J. S., Jenssen, T. G., & Hartmann, A. (2006) · Clinical Transplantation · doi:10.1111/j.1399-0012.2005.00465.x · Cited by 7
Association of the D8S282 marker near the lipoprotein lipase gene locus with systolic blood pressure in healthy Chinese subjects
Ma, Y., Thomas, G. N., Critchley, J. A., Lee, Z. S. K., Chan, J. C. N., & Tomlinson, B. (2002) · Journal of Hypertension · doi:10.1097/00004872-200211000-00019 · Cited by 7
Targeting Mitochondrial Dysfunction to Prevent Endothelial Dysfunction and Atherosclerosis in Diabetes: Focus on the Novel Uncoupler BAM15
Jang, W. B., Rethineswaran, V. K., & Kwon, S. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26104603 · Cited by 6
Investigating Diabetic Foot Pathophysiology and Amputation Prevention Strategies through Behavioral Modification
Kim, J. H. (2023) · Journal of Wound Management and Research · doi:10.22467/jwmr.2023.02747 · Cited by 6
Spinosin ameliorates insulin resistance by suppressing reactive oxygen species-associated inflammation.
Ge, C., Yang, L., Zhang, J., Wei, Z., & Feng, F. (2022) · PubMed Central · doi:10.22038/ijbms.2022.64154.14127 · Cited by 6
Non-esterified fatty acids and risk of peripheral artery disease in older adults: The cardiovascular health study
Ahiawodzi, P. D., Solaru, K. W., Chaves, P. H. M., Ix, J. H., Kizer, J. R., Tracy, R. P., Newman, A. B., Siscovick, D. S., Djoussé, L., & Mukamal, K. J. (2023) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2023.01.020 · Cited by 7
Serum growth differentiation factor-15 and non-esterified fatty acid levels in patients with coronary artery disease and hyperuricemia
Cheng, J., Lyu, Y., Mei, Y., Chen, Q., Liu, H., & Li, Y. (2023) · Lipids in Health and Disease · doi:10.1186/s12944-023-01792-5 · Cited by 6
The effects of fenofibrate on metabolic and vascular changes induced by chocolate-supplemented diet in the rat
Naderali, E. K., & Fatani, S. H. (2005) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2005.07.027 · Cited by 6
Reduced coronary reserve in response to short‐term ischaemia and vasoactive drugs in ex vivo hearts from diabetic mice
Bratkovsky, S., Aasum, E., Riemersma, R. A., Myhre, E. S. P., & Larsen, T. S. (2006) · Acta Physiologica · doi:10.1111/j.1748-1716.2006.01527.x · Cited by 6
The Metabolic Syndrome Adds Incremental Value to the Framingham Risk Score in Identifying Asymptomatic Individuals With Higher Degrees of Inflammation
Campbell, C. Y., Nasir, K., Carvalho, J. A. M., Blumenthal, R. S., & Santos, R. D. (2008) · Journal of the CardioMetabolic Syndrome · doi:10.1111/j.1559-4572.2008.06670.x · Cited by 6
Alcohol: Effects on Nutritional Status, Lipid Profile and Blood Pressure
Toffolo (2012) · Journal of Endocrinology and Metabolism · doi:10.4021/jem128e · Cited by 23
Vascular Endothelial Function
Widlansky, M. E., & Malik, M. A. (2015) · Springer eBooks · doi:10.1007/978-3-642-37078-6_8 · Cited by 6
Endothelial Nitric Oxide Synthase as a Mediator of the Positive Health Effects of Mediterranean Diets and Wine against Metabolic Syndrome
Leighton, F., & Urquiaga, I. (2006) · KARGER eBooks · doi:10.1159/000097875 · Cited by 6
Dyslipidemia and pre-eclampsia
Hubel, C. A. (2001) · Cambridge University Press eBooks · doi:10.1017/cbo9780511545634.012 · Cited by 6
A preliminary fast may potentiate response to a subsequent low-salt, low-fat vegan diet in the management of hypertension – fasting as a strategy for breaking metabolic vicious cycles
McCarty, M. F. (2003) · Medical Hypotheses · doi:10.1016/s0306-9877(02)00228-1 · Cited by 6
Effects of Orlistat/Phentermine versus Phentermine on Vascular Endothelial Cell Function in Obese and Overweight Adults: A Randomized, Double-Blinded, Placebo-Controlled Trial
Kwon, Y., Lee, H., Nam, C. M., Chang, H., Yoon, Y.-R., Lee, H. S., & Lee, J. (2021) · Diabetes Metabolic Syndrome and Obesity · doi:10.2147/dmso.s300342 · Cited by 5
Iatrogenic lipodystrophy in HIV patients – the need for very-low-fat diets
McCarty, M. F. (2003) · Medical Hypotheses · doi:10.1016/s0306-9877(03)00230-5 · Cited by 4
Plasma levels of adiponectin and chemerin are associated with early stage of atherosclerosis in older adults with type 2 diabetes mellitus
Li, H., Zhan, J., Liao, B., Wang, Y., & Liu, Y. (2019) · Aging Medicine · doi:10.1002/agm2.12087 · Cited by 4
Nonesterified Fatty Acids and Kidney Function Decline in Older Adults: Findings From the Cardiovascular Health Study
Walther, C. P., Ix, J. H., Biggs, M. L., Kizer, J. R., Navaneethan, S. D., Djoussé, L., & Mukamal, K. J. (2021) · American Journal of Kidney Diseases · doi:10.1053/j.ajkd.2020.11.030 · Cited by 5
Features of Metabolite Changes in Disease Evolution in Cholecystolithiasis
Zhang, K., Wang, Y., Cui, X., Wang, W., & Li, Y. (2023) · Digestive Diseases and Sciences · doi:10.1007/s10620-023-08134-6 · Cited by 5
Oxidants and Endothelial Dysfunction
Lund, A. K. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-801238-3.65250-9 · Cited by 6
Nitric Oxide and Its Role in Diabetes Mellitus
Johnstone, M. T., & Gelfand, E. V. (2005) · Humana Press eBooks · doi:10.1385/1-59259-908-7:201 · Cited by 5
The types of circulating fatty acids influence vascular reactivity
Lind, L., Södergren, E., Gustafsson, I., Millgård, J., Sarabi, M., & Vessby, B. O. (2002) · Lipids · doi:10.1007/s11745-002-1011-2 · Cited by 5
Rosiglitazone Prevents Free Fatty Acid-Induced Vascular Endothelial Dysfunction
Mittermayer, F., Schaller, G., Pleiner, J., Krzyżanowska, K., Kapiotis, S., Roden, M., & Wolzt, M. (2007) · Obstetrical & Gynecological Survey · doi:10.1097/01.ogx.0000292007.85472.c2 · Cited by 5
Oleic Acid Inhibits the KATP Channel Subunit Kir6.1 and the KATP Current in Human Umbilical Artery Smooth Muscle Cells
Bai, X., Tian, H., Wang, T., Du, Y., Xi, Y. T., Wu, Y., Gao, J., & Ma, A. (2012) · The American Journal of the Medical Sciences · doi:10.1097/maj.0b013e31826ba186 · Cited by 5
Álcool e Doença Aterosclerótica
Foppa, M., Fuchs, F. D., & Duncan, B. B. (2001) · Americanae (AECID Library) · Cited by 5
Relationships between serum free fatty acid and pulse pressure amplification in overweight/obese men: insights from exercise training and dietary modification
Yoshikawa, T., Zempo‐Miyaki, A., Kumagai, H., Myoenzono, K., So, R., Tsujimoto, T., Tanaka, K., & Maeda, S. (2018) · Journal of Clinical Biochemistry and Nutrition · doi:10.3164/jcbn.17-103 · Cited by 4
Vascular effects of insulin
Natali, A., & Nesti, L. (2021) · Metabolism · doi:10.1016/j.metabol.2021.154891 · Cited by 4
Predictors of unexplained early neurological deterioration after thrombectomy for posterior circulation infarction: a reanalysis of the BASILAR study
Dai, Z., Cheng, D., Peng, D., Wang, C., Tian, Y., Yang, D., Liu, X., Yang, J., Hu, J., Li, F., et al. (2024) · Journal of neurosurgery · doi:10.3171/2024.4.jns232632 · Cited by 4
Mesenteric Visceral Lipectomy Improves Glucose Tolerance in Patients With Type 2 Diabetes: A Pilot Study
Baskoy, G., Peterson, R. M., Kempenich, J. W., Triplitt, C. L., Brown, M., Clarke, G. D., Cersósimo, E., Mark, A., Lavrynenko, O., Chavez-Velazquez, A., et al. (2024) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgae872 · Cited by 4
Fat Metabolism in Insulin Resistance and Type 2 Diabetes
Duez, H., & Lewis, G. F. (2008) · Humana Press eBooks · doi:10.1007/978-1-60327-043-4_4 · Cited by 4
A high carbohydrate meal yields a lower ischemic threshold than a high fat meal in patients with stable coronary disease
Fragasso, G., Montano, C., Lattuada, G., Salerno, A., Palloshi, A., Calori, G., Luzi, L., Perseghin, G., & Margonato, A. (2009) · International Journal of Cardiology · doi:10.1016/j.ijcard.2009.08.023 · Cited by 4
Lipid Emulsions Containing Medium Chain Triacylglycerols Blunt Bradykinin‐Induced Endothelium‐Dependent Relaxation in Porcine Coronary Artery Rings
Amissi, S., Helms, J., Burban, M., Rashid, S. K., León‐González, A. J., Auger, C., Toti, F., Meziani, F., & Schini‐Kerth, V. B. (2017) · Lipids · doi:10.1007/s11745-016-4225-y · Cited by 4
Fat Consumption Attenuates Cortical Oxygenation during Mental Stress in Young Healthy Adults
Baynham, R., Lucas, S. J. E., Weaver, S. R., Zanten, J. V., & Rendeiro, C. (2023) · Nutrients · doi:10.3390/nu15183969 · Cited by 4
The effects of lipophilic substances on the shape of erythrocytes demonstrated by a new in vitro-method
Söderberg, L., Haag, L., Höglund, P., Roth, B., Stenberg, P. B., & Wahlgren, M. (2008) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2008.11.011 · Cited by 4
Cellular and Functional Effects of Insulin Based Therapies and Exercise on Endothelium
Luse, M. A., Heiston, E. M., Malin, S. K., & Isakson, B. E. (2020) · Current Pharmaceutical Design · doi:10.2174/1381612826666200721002735 · Cited by 4
Is there a role for wine in cancer and the degenerative diseases of aging?
Stockley, C. S. (2009) · International Journal of Wine Research · doi:10.2147/ijwr.s4591 · Cited by 4
Defining the benefits of euglycemia in the hospitalized patient
Braithwaite, S. S. (2007) · Journal of Hospital Medicine · doi:10.1002/jhm.155 · Cited by 4
Diagnosis of arterial stiffness using the cardio-ankle vascular index. Expert consensus
Podzolkov, V. I., Safronova, T. A., Vasyuk, Y. A., Kotovskaya, Y. V., Кislyak, O. A., Starodubova, A. V., Kopylov, P., Evsevyeva, M. E., Sumin, A. N., Tarzimanova, A. I., et al. (2025) · CARDIOVASCULAR THERAPY AND PREVENTION · doi:10.15829/1728-8800-2025-4481 · Cited by 3
Long-term outcomes of unselected patients undergoing coronary angiography according to the presence or absence of type II diabetes mellitus
Steinke, P., Schupp, T., Kuhn, L., Abumayyaleh, M., Ayoub, M., Mashayekhi, K., Bertsch, T., Ayasse, N., Jannesari, M., Siegel, F. P., et al. (2024) · Cardiovascular revascularization medicine · doi:10.1016/j.carrev.2024.12.001 · Cited by 3
The Role of Serum Free Fatty Acids in Endothelium‐Dependent Microvascular Function
Sullivan, A. E., Courvan, M. C., Aday, A. W., Wasserman, D. H., Niswender, K. D., Shardelow, E., Wells, E. K., Wells, Q. S., Freiberg, M. S., & Beckman, J. A. (2025) · Endocrinology Diabetes & Metabolism · doi:10.1002/edm2.70031 · Cited by 3
Vascular Endothelial Function
Widlansky, M. E., & Malik, M. A. (2014) · Springer eBooks · doi:10.1007/978-3-642-37393-0_8-1 · Cited by 3

Authors: Steinberg, H. O., Tarshoby, M., Monestel, R., Hook, G., Cronin, J., Johnson, A., Bayazeed, B., & Baron, A. D.
Affiliations: Indiana University (US)
Indiana University – Purdue University Indianapolis (US)
ORCID: Tarshoby, M
Venue: Journal of Clinical Investigation
Publisher: American Society for Clinical Investigation
Published: 1997-09-01
Volume: 100
Issue: 5
Pages: 1230-1239
ISSN: 0021-9738 (ISSN-L)
DOI: 10.1172/jci119636
PMC: PMC508300
OpenAlex: W2086785365
Cited by: 761
References: 16
Citations by year: 2026: 6 · 2025: 12 · 2024: 17 · 2023: 20 · 2022: 9 · 2021: 19 · 2020: 29 · 2019: 11 · 2018: 19 · 2017: 20 · 2016: 12 · 2015: 22 · 2014: 17 · 2013: 28 · 2012: 33
FWCI: 10.61
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Journal of Clinical Investigation (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: U.S. Department of Veterans Affairs
American Heart Association
National Institutes of Health
National Institute of Diabetes and Digestive and Kidney Diseases (DK 20452, DK42469)
National Center for Research Resources (MO1-RR75019)
Topics: Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
Keywords: free fatty acids, endothelial dysfunction, endothelium-dependent vasodilation, insulin resistance, methacholine, sodium nitroprusside, leg blood flow, somatostatin, insulin deficiency, Intralipid, obesity, insulin replacement therapy
MeSH terms: Adult, Blood Pressure, Endothelium, Vascular, Fat Emulsions, Intravenous, Fatty Acids, Nonesterified, Female, Humans, Insulin, Leg, Male, Nitroprusside, Somatostatin, Vasodilation, Methacholine Chloride

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Elevated circulating free fatty acid levels impair endothelium-dependent vasodilation

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks