The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.
Sex steroids and bone mass in older men. Positive associations with serum estrogens and negative associations with androgens.
Open accessAbstract
The purpose of this study was to determine whether bone density in older men was associated with serum sex steroids or sex hormone binding globulin (SHBG). Bone density and sex steroids were measured in men over age 65 at 6-mo intervals for an average of 2.1 yr. Bone density was significantly positively associated with greater serum E2 concentrations (+0.21 < r < +0.35; 0.01 < P < 0.05) at all skeletal sites. There were weak negative correlations between serum testosterone and bone density (-0.20 < r < -0.28; 0.03 < P < 0.10) at the spine and hip. SHBG was negatively associated only with bone density in the greater trochanter (r = -0.26, P < 0.05). Greater body weight was associated with lower serum testosterone and SHBG, and greater E2. Because of these associations, regression models which adjusted for age, body weight, and serum sex steroids were constructed; these accounted for 10-30% of the variability in bone density, and showed consistent, significant positive associations between bone density and serum E2 concentrations in men, even after adjustments for weight and SHBG. These data suggest that estrogens may play an important role in the development or maintenance of the male skeleton, much as is the case for the female skeleton. These data also indicate that, within the normal range, lower serum testosterone concentrations are not associated with low bone density in men.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Moreover, in men, bone mineral density (BMD) at the greater trochanter, femoral neck and the lumbar spine is negatively correlated with concentrations of SHBG [146, 150–152].”
From Role of sex hormone-binding globulin in the free hormone hypothesis and the relevance of free testosterone in androgen physiology (2022) · cites this paper as [151]
Experimental — accuracy not yet measuredIn the citing paper
“These confounding results leave uncertainty in the relationship between T levels in aging and bone health.”
From Hormonal and Metabolic Changes of Aging and the Influence of Lifestyle Modifications (2021) · cites this paper as [175]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Estrogen Resistance Caused by a Mutation in the Estrogen-Receptor Gene in a Man
Smith, E. P., Boyd, J., Frank, G. R., Takahashi, H., Cohen, R. M., Specker, B., Williams, T. C., Lubahn, D. B., & Korach, K. S. (1994) · New England Journal of Medicine · doi:10.1056/nejm199410203311604 · Cited by 2,471
Cooper, C. C., Atkinson, E. J., MichaelO'Fallon, W., & Melton, J. L. (1992) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.5650070214 · Cited by 1,526
Morishima, A., Grumbach, M. M., Simpson, E. R., Fisher, C., & Qin, K. (1995) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.80.12.8530621 · Cited by 1,416
Khosla, S., Amin, S., & ORWOLL, E. S. (2008) · Endocrine Reviews · doi:10.1210/er.2008-0002 · Cited by 943
LONG-TERM PREVENTION OF POSTMENOPAUSAL OSTEOPOROSIS BY ŒSTROGEN
Lindsay, R., Aitken, J. M., Anderson, L., Hart, D., Macdonald, E., & Clarke, A. (1976) · The Lancet · doi:10.1016/s0140-6736(76)92217-0 · Cited by 875
Estrogen Replacement Therapy and Fractures in Older Women
Cauley, J. A., Seeley, D. G., Ensrud, K. E., Ettinger, B., Black, D., & Cummings, S. R. (1995) · Annals of Internal Medicine · doi:10.7326/0003-4819-122-1-199501010-00002 · Cited by 808
Katznelson, L., Finkelstein, J. S., Schoenfeld, D. A., Rosenthal, D. I., Anderson, E. J., & Klibanski, A. (1996) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.81.12.8954042 · Cited by 791 · cited 2×
“Men with spinal crush fractures have also been shown to have significantly higher serum concentrations of markers of skeletal remodeling (osteocalcin) (22), and it is possible that this mechanism, which is clearly central to the development of low bone mass in women, is also involved in the development of low bone mas…”
BackgroundGenetic Factors in Determining Bone Mass
Smith, D. M., Nance, W. E., Kang, K.-W., Christian, J. C., & Johnston, C. C. (1973) · Journal of Clinical Investigation · doi:10.1172/jci107476 · Cited by 579
Self-citationPrediction of osteoporotic fractures by postural instability and bone density.
Nguyen, T. V., Sambrook, P. N., Kelly, P. J., Jones, G., Lord, S. R., Freund, J., & Eisman, J. A. (1993) · BMJ · doi:10.1136/bmj.307.6912.1111 · Cited by 568
ANDROGENS DIRECTLY STIMULATE PROLIFERATION OF BONE CELLS IN VITRO
Kasperk, C. H., Wergedal, J. E., Farley, J. R., Linkhart, T. A., Turner, R. T., & Baylink (1989) · Endocrinology · doi:10.1210/endo-124-3-1576 · Cited by 398
Flagged first, then by citations
Cited by
Sorted by citations
Items 301–400 of 454
Sex-dependent variation in bone adaptation: from degeneration to regeneration
Chen, S., Patel, J., Katzmeyer, T., & Pei, M. (2025) · Journal of Orthopaedic Translation · doi:10.1016/j.jot.2025.04.011 · Cited by 12
“Androgen replacement therapy has not been heavily researched, but current findings support that treatment can reduce bone resorption markers and improve calcium absorption for hypogonadal males [180, 203,204].”
Estrogen deficiency and the pathogenesis of osteoporosis
Khosla, S., & Pacifici, R. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-813073-5.00032-0 · Cited by 13
Lasofoxifene (CP-336,156), a novel selective estrogen receptor modulator, in preclinical studies
Ke, H. Z., Brown, T. A., & Thompson, D. D. (2002) · AGE · doi:10.1007/s11357-002-0007-y · Cited by 10
Estrogen Receptors Critically Regulate Bones’ Adaptive Responses to Loading
Lanyon, L. E., Armstrong, V. J., Saxon, L., Sunters, A., Sugiyama, T., Zaman, G., & Price, J. S. (2007) · Clinical Reviews in Bone and Mineral Metabolism · doi:10.1007/s12018-008-9011-9 · Cited by 10
“In both sexes one of the most significant correlates with the bone loss responsible for this skeletal fragility is the level of bio-available estrogen ([18–20], reviewed in [21]).”
BackgroundEstrogen Effects on Bone in the Male Skeleton
Gennari, L., Khosla, S., & Bilezikian, J. P. (2008) · Elsevier eBooks · doi:10.1016/b978-0-12-373884-4.00022-7 · Cited by 10
What’s Good for the Goose’s Skeleton is Good for the Gander’s Skeleton
Bilezikian, J. P. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2006-0082 · Cited by 10
Extra-nuclear effects of estrogen on cortical bone in males require ERαAF-1
Farman, H. H., Wu, J., Gustafsson, K. L., Windahl, S. H., Kim, S. H., Katzenellenbogen, J. A., Ohlsson, C., & Lagerquist, M. K. (2017) · Journal of Molecular Endocrinology · doi:10.1530/jme-16-0209 · Cited by 9
Hage, R. E., Mina, F., Ayoub, M.-L., Theunynck, D., & Baddoura, R. (2012) · PubMed · Cited by 9
Abdelsamie, A. S., Salah, M., Siebenbürger, L., Hamed, M. M., Börger, C., van Koppen, C. J., Frotscher, M., & Hartmann, R. W. (2019) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2019.05.084 · Cited by 9
Role of sex steroids in the regulation of bone metabolism in the adult skeleton
Kaufman, J.-M. (2006) · Annales d Endocrinologie · doi:10.1016/s0003-4266(06)72565-3 · Cited by 8
“In any case, multivariate analysis of crosssectional studies consistently indicated that free or bioavailable E2 is a better predictor of prevalent BMD in elderly men than free or bioavailable T [1, 7, 15, 20, 31, 36, 42, 45, 48].”
BackgroundAn overview of osteoporosis for the practising prosthodontist
Singh, S. V., & Tripathi, A. (2009) · Gerodontology · doi:10.1111/j.1741-2358.2009.00324.x · Cited by 9
Chanetsa, F. F., Hillman, L. S., Thomas, M. G., & Keisler, D. H. (2000) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2000.15.7.1361 · Cited by 9
“((13,14))In two isolated cases, a man with absence of the a- strogen receptor and a man with aromatase-deficiency abnormalities of bone growth have been reported.”
BackgroundEstrogen, Bone Homeostasis, and Osteoporosis
Riggs, B. L., Khosla, S., & Melton, L. J. (2008) · Elsevier eBooks · doi:10.1016/b978-012370544-0.50042-2 · Cited by 9
Grundberg, E., Åkesson, K., Kindmark, A., Gerdhem, P., Holmberg, A. H., Mellström, D., Ljunggren, Ö., ORWOLL, E. S., Mallmin, H., Ohlsson, C., et al. (2007) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2006-1572 · Cited by 8
Implementation of personalized medicine for fracture risk assessment in osteoporosis
Mori, S., & Zhou, H. (2016) · Geriatrics and gerontology international/Geriatrics & gerontology international · doi:10.1111/ggi.12721 · Cited by 8
Bone stiffness in men with type 2 diabetes mellitus
Asano, M., Fukui, M., Hosoda, H., Shiraishi, E., Harusato, I., Kadono, M., Tanaka, M., Hasegawa, G., Yoshikawa, T., & Nakamura, N. (2008) · Metabolism · doi:10.1016/j.metabol.2008.07.025 · Cited by 9
ORWOLL, E. S., & Klein, R. F. (2001) · Elsevier eBooks · doi:10.1016/b978-012470862-4/50043-x · Cited by 10
Weisinger, J. R. (2000) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/15.suppl_5.36 · Cited by 8
ORWOLL, E. S. (1999) · Elsevier eBooks · doi:10.1016/b978-012528640-4/50014-9 · Cited by 8
Sex differences in skeletal development
Fitzpatrick, L. A. (2004) · Advances in molecular and cell biology · doi:10.1016/s1569-2558(03)34016-0 · Cited by 7
The impact of biological clock and sex hormones on the risk of disease
Furtado, A., Costa, D. R. B., Lemos, M. C., Cavaco, J. E. B., Santos, C. R. A., & Quintela, T. (2023) · Advances in protein chemistry and structural biology · doi:10.1016/bs.apcsb.2023.03.004 · Cited by 8
RANKL-Targeted Therapies: The Next Frontier in the Treatment of Male Osteoporosis
Morgans, A. K., & Smith, M. R. (2011) · Journal of Osteoporosis · doi:10.4061/2011/941310 · Cited by 7
“Additionally, levels of estradiol in healthy older men correlate with spinal bone mineral density and are inversely associated with vertebral fracture risk [20–22].”
BackgroundSex Steroid Effects on Bone Metabolism
Monroe, D. G., Spelsberg, T. C., & Khosla, S. (2006) · Elsevier eBooks · doi:10.1016/b978-012088562-6/50020-0 · Cited by 7
Wada, S., Minagawa, A., Imamaki, K., Satoru, S. U. D. A., Yamanaka, K., Iitaka, M., & Katayama, S. (2000) · Internal Medicine · doi:10.2169/internalmedicine.39.641 · Cited by 7
Vasilkova, V., Mokhort, T., Sanec, I., Михайловна, Ш. Т., Hayashida, N., & Takamura, N. (2010) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm.2011.016 · Cited by 8
“Testosterone is necessary for the aromatization and formation of estrogen in the testicles and surrounding tissue (16).”
BackgroundHuuskonen, J., Väisänen, S., Kröger, H., Jurvelin, J. S., Penttila, I. M., ALHAVA, E. M., & Rauramaa, R. (2002) · Bone · doi:10.1016/s8756-3282(02)00795-0 · Cited by 7
Osteoporosis in chronic obstructive pulmonary disease
Graat‐Verboom, L. (2012) · Research Publications (Maastricht University) · doi:10.26481/dis.20120316lg · Cited by 7
Hanusch, B. C., Prediger, M., Tuck, S. P., Walker, J., McNally, R., & Datta, H. K. (2021) · Osteoporosis International · doi:10.1007/s00198-021-06001-6 · Cited by 6
Polymorphisms of SLC22A9 (hOAT7) in Korean Females with Osteoporosis
Ahn, S. K., Suh, C. K., & Ho, S. (2015) · Korean Journal of Physiology and Pharmacology · doi:10.4196/kjpp.2015.19.4.319 · Cited by 6
“The important factor in determining bone density and bone turnover in humans is circulating estradiol [5-9].”
BackgroundEstrogen in men: effects on bone accrual, maintenance and prevention of bone loss
Gennari, L., Nuti, R., & Bilezikian, J. P. (2006) · Expert Review of Endocrinology & Metabolism · doi:10.1586/17446651.1.2.281 · Cited by 6
Testosterone supplementation, glucocorticoid milieu and bone homeostasis in the ageing male
Ajdžanović, V. Z., Filipović, B. R., Šošić‐Jurjević, B., & Milošević, V. (2017) · Fundamental and Clinical Pharmacology · doi:10.1111/fcp.12277 · Cited by 6
Yoshida, T., Wang, J., & Stern, P. H. (2019) · Handbook of experimental pharmacology · doi:10.1007/164_2019_327 · Cited by 6
Osteoporosis in Men: Pathophysiology and treatment
Gennari, L., & Bilezikian, J. P. (2007) · Current Osteoporosis Reports · doi:10.1007/bf02938619 · Cited by 6
“Since 40% to 50% of middle-aged men have estradiol levels below this threshold, it could be a determinant in agerelated bone loss in many men [ 24-29 ].”
BackgroundNutrition and Bone Health in the Elderly
Rosen, C. J. (2004) · Humana Press eBooks · doi:10.1007/978-1-59259-740-6_13 · Cited by 6
“In one prospective study, Slemenda et al. noted that both estrogens and androgens were independent predictors of bone loss in older postmenopausal women ( 37 ).”
BackgroundTreatment Considerations in the Management of Age-Related Osteoporosis
Kaplan, N. M., Palmer, B. F., & Rubin, C. D. (1999) · The American Journal of the Medical Sciences · doi:10.1016/s0002-9629(15)40608-1 · Cited by 5
Chapter 41. Role of Sex Steroids in the Pathogenesis of Osteoporosis
Drake, M. T., & Khosla, S. (2008) · Primer on the metabolic bone diseases and disorders of mineral metabolism · doi:10.1002/9780470623992.ch41 · Cited by 6
Sex Steroids and the Pathogenesis of Osteoporosis
Drake, M. T., & Khosla, S. (2018) · Wiley eBooks · doi:10.1002/9781119266594.ch52 · Cited by 7
Horkeby, K., Farman, H. H., Movérare‐Skrtic, S., Lionikaite, V., Wu, J., Henning, P., Windahl, S. H., Sjögren, K., Ohlsson, C., & Lagerquist, M. K. (2022) · Scientific Reports · doi:10.1038/s41598-022-26939-9 · Cited by 5
Osteoporosis in the aging population: the male perspective
Kaufman, J., Zmierczak, H., & Goemaere, S. (2001) · The Aging Male · doi:10.1080/713604602 · Cited by 5
Ma, H.-J., Fu, S., Xiao, A., Cai, W.-K., Wang, P., Shen, M.-L., Li, Z., & He, G. (2020) · Gynecological Endocrinology · doi:10.1080/09513590.2020.1727431 · Cited by 5
“The reason might be ascribed to the heterozygote superiority, which means that heterozygotes (AG genotype) may exhibit more elastic and broader gene expression profiles for specific stimuli or cytospecificity as compared with the rest 2 genotypes (AA and GG) [32,33].”
BackgroundAtsumi, Y., Rino, Y., Aoyama, T., Okuda, N., KAWAHARA, S., Kazama, K., Numata, M., Tamagawa, H., Oshima, T., Yukawa, N., et al. (2021) · In Vivo · doi:10.21873/invivo.12510 · Cited by 5
Traditional Japanese apricot (Prunus mume) induces osteocalcin in osteoblasts
Nomura, S., Kono, R., Imaoka, M., Tazaki, F., Okuno, Y., Utsunomiya, H., Takeda, M., & Nakamura, M. (2022) · Bioscience Biotechnology and Biochemistry · doi:10.1093/bbb/zbac013 · Cited by 5
Gonadal Steroids and the Skeleton in Men
Leder, B. Z., & Finkelstein, J. S. (2003) · Humana Press eBooks · doi:10.1007/978-1-59259-278-4_19 · Cited by 10
Pharmacology, pharmacokinetics and effects/side-effects of different androgen preparations
von Eckardstein, S., & Nieschlag, E. (1998) · The Aging Male · doi:10.3109/13685539809148600 · Cited by 5
Hormonal and Biochemical Parameters in the Determination of Osteoporosis in Elderly Men*
Center, J. R., Nguyen, T. V., Sambrook, P. N., & Eisman, J. A. (1999) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.84.10.6051 · Cited by 189
Li, S., Li, W., Chang, L., Wan, J., Chen, S., Zhang, X., He, Q., & Liu, M. R. (2024) · Journal of Bone and Mineral Metabolism · doi:10.1007/s00774-024-01511-9 · Cited by 4
Filipović, B. R., Šošić‐Jurjević, B., Ajdžanović, V. Z., Živanović, J., Isenović, E. R., Popovska‐Perčinić, F., & Milošević, V. (2015) · Journal of Anatomy · doi:10.1111/joa.12298 · Cited by 4
“Accepted for publication 13 February 2015 Article published online 7 April 2015 © 2015 Anatomical Society investigations indicate that, together with the lack of testosterone, estrogen deficiency plays an important role in age-related bone loss in elderly men (Slemenda et al. 1997).”
BackgroundEarly Castration in Horses Does Not Impact Osteoarticular Metabolism
Rouge, M., Legendre, F., Elkhatib, R., Delalande, C., Cognié, J., Reigner, F., Barrière, P., Deleuze, S. C., Hanoux, V., Galéra, P., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242316778 · Cited by 6
The Role of the Immune System in the Development of Osteoporosis
Mödder, U. I., Riggs, B. L., & Khosla, S. (2010) · Elsevier eBooks · doi:10.1016/b978-0-12-375670-1.10009-3 · Cited by 4
Yusuh, M., Phochanukoon, N., Radenahmad, N., Eksomtramate, M., Ruangsri, P., Chantanasuksilpa, A., & Nitiruangjaras, A. (2010) · DOAJ (DOAJ: Directory of Open Access Journals) · Cited by 4
Osteoporosis Associated with Cancer Therapy
Heras-Herzig, A., Kozlow, W., Brown, S. A., & Guise, T. A. (2008) · Elsevier eBooks · doi:10.1016/b978-012370544-0.50056-2 · Cited by 4
Osteoporosis in men: Are we ready to diagnose and treat?
Perry, H. M., & Morley, J. E. (2001) · Current Rheumatology Reports · doi:10.1007/s11926-001-0024-3 · Cited by 4
“Recent reports suggest that serum estrogen predicts bone mass in older men, better than does serum testosterone [ 28 ,29].”
BackgroundTałałaj, M., Kapitan-Malinowska, B., Dębski, K., Nowakowski, R., Marcinowska-Suchowierska, E., & Witeska, A. (2005) · PubMed · Cited by 4
Can DHEA be used to prevent bone loss and osteoporosis?
Marcelli, C. (2003) · Joint Bone Spine · doi:10.1016/s1297-319x(02)00002-7 · Cited by 4
Carnevale, V., Scillitani, A., Vecci, E., D'Erasmo, E., Romagnoli, E., Paglia, F., Pepe, J., Baldini, V., Santori, C., Geronimo, S. D., et al. (2005) · Journal of Endocrinological Investigation · doi:10.1007/bf03345350 · Cited by 4
Park, K., Park, Y., Suh, M., & Choi‐Kwon, S. (2015) · Asian Nursing Research · doi:10.1016/j.anr.2015.05.006 · Cited by 3
“It may have been due to the greater strength of biochemical forces [69] and a greater aromatization of androgens in the subcutaneous adipose tissue in men [70].”
BackgroundSecondary Causes of Osteoporosis in Men
Ebeling, P. R. (1999) · Elsevier eBooks · doi:10.1016/b978-012528640-4/50024-1 · Cited by 3
Doran, P. M., Turner, R. T., Riggs, B. L., & Khosla, S. (1999) · Elsevier eBooks · doi:10.1016/b978-012528640-4/50015-0 · Cited by 3
Osteoporosis in men: Pathophysiology and treatment
Gennari, L., & Bilezikian, J. P. (2008) · Current Sexual Health Reports · doi:10.1007/s11930-008-0015-8 · Cited by 3
[Age-related androgen deficiency: diagnostic work-up].
Rossi, D., & Tostain, J.-B. (2004) · PubMed · Cited by 3
Bone Mineral Density of the Calcaneus and Related Factors in Men.
Shono, N., Kondo, Y., Higaki, Y., & Nishizumi, M. (2000) · Nippon Eiseigaku Zasshi (Japanese Journal of Hygiene) · doi:10.1265/jjh.55.516 · Cited by 3
Liu, H.-J., Yan, J., Li, Y., Zhou, F., Su, X., Fan, H.-J., Bai, J., & Zhang, G. (2018) · Hormone and Metabolic Research · doi:10.1055/s-0043-116672 · Cited by 3
Racial Determinants of Peak Bone Mass
Key, L. L., & Bell, N. H. (1999) · Elsevier eBooks · doi:10.1016/b978-012098655-2/50014-4 · Cited by 3
Smith, M. R. (2006) · Kluwer Academic Publishers eBooks · doi:10.1007/0-306-48143-x_26 · Cited by 3
Venken, K., Boonen, S., Bouillon, R., & Vanderschueren, D. (2008) · Wiley eBooks · doi:10.1002/9780470623992.ch24 · Cited by 3
Biochemical Markers and Bone Mineral Density in Patients with Hip Fractures in Men
Ohishi, T., Takahashi, M., KUSHIDA, K., & Omura, T. (2000) · Endocrine Research · doi:10.3109/07435800009066167 · Cited by 3
Estrogen and the Skeleton – Rodents
Callewaert, F., Venken, K., Boonen, S., & Vanderschueren, D. (2010) · Elsevier eBooks · doi:10.1016/b978-0-12-374602-3.00023-7 · Cited by 2
Pathophysiology and Aging of Bone
Pietschmann, P., Gruber, R., & Peterlik, M. (2008) · Medical radiology · doi:10.1007/978-3-540-68604-0_2 · Cited by 2
Nutrition and bone health in the elderly
Cederholm, T. (2009) · Elsevier eBooks · doi:10.1533/9781845695484.2.252 · Cited by 2
Androgènes et métabolisme osseux
Alexandre, C. (2004) · Revue du Rhumatisme · doi:10.1016/j.rhum.2004.04.010 · Cited by 2
Envejecimiento músculo-esquelético
Martínez, J. M. O., García, J. M., & Macías, J. G. (2007) · Revista Española de Enfermedades Metabólicas Óseas · doi:10.1016/s1132-8460(07)73495-5 · Cited by 2
Rahnama, M., & Tomaszewski, T. (2002) · Cited by 2
Kumar, Y. S., Jain, A., Ashok, K., & Anangpuria, B. S. (2010) · International Journal of Pharmacy and Life Sciences · Cited by 2
Smoking, Alcohol, and Bone Health
Kiel, D. P. (2004) · Humana Press eBooks · doi:10.1007/978-1-59259-740-6_28 · Cited by 2
Gonadal hormones and their influence on skeletal health in men
Meier, C., & KRAENZLIN, M. E. (2007) · The Journal of Men s Health and Gender · doi:10.1016/j.jmhg.2006.06.007 · Cited by 2
“By analogy to markers of bone turnover, several cross-sectional and longitudinal studies have documented significant correlations between serum levels of ‘‘bioavailable’’ or total E2 and bone density [40,41] or changes in bone mass during follow-up [85–87].”
BackgroundResultOury, F. (2012) · Elsevier eBooks · doi:10.1016/b978-0-12-415784-2.00011-7 · Cited by 2
Osteoporosis in men: what is similar and what is different?
Laurent, M. R., Gielen, E., ORWOLL, E. S., & Vanderschueren, D. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-813073-5.00025-3 · Cited by 2
Omega 3 fatty acids favour lipid and bone metabolism in orchidectomised rats
Adeyemi, W. J., Lawal, S. I., Olatunji, D. B., Daoudu, K. T., Ogunlowo, O. T., & Olayaki, L. A. (2021) · Clinical Nutrition Open Science · doi:10.1016/j.nutos.2021.01.002 · Cited by 2
Zerbini, C. A. F., & Pippa, M. G. B. (2012) · Revista Paulista de Reumatologia · doi:10.46833/reumatologiasp.2011.10.s1.48-54 · Cited by 2
New hopes in the treatment of osteoporosis in men
Kaštelan, D., & Koršić, M. (2007) · Future Rheumatology · doi:10.2217/17460816.2.1.1 · Cited by 2
Southwestern Internal Medicine Conference
Rubin, C. D. (1999) · The American Journal of the Medical Sciences · doi:10.1097/00000441-199909000-00011 · Cited by 2
Androgen Deprivation and Osteoporosis
Smith, M. R. (1999) · The Prostate Journal · doi:10.1046/j.1525-1411.1999.14002.x · Cited by 2
Men with osteoporosis: are they being treated fairly?
Legrand, É. (2001) · Joint Bone Spine · doi:10.1016/s1297-319x(01)00270-6 · Cited by 2
Frequency of low bone mass in elderly males attending an academic geriatric clinic: a pilot study
Ojo, F., & Edwards, B. J.-A. (2003) · The Aging Male · doi:10.1080/713604784 · Cited by 2
Sex Steroids and Osteoporosis: The Role of Estrogens and Androgens
Adler, R. A. (2000) · Clinics in Laboratory Medicine · doi:10.1016/s0272-2712(18)30052-0 · Cited by 2
Sex Steroids and Skeletal Health in Men
Meier, C., Liu, P. Y., Seibel, M. J., & Handelsman, D. J. (2006) · Elsevier eBooks · doi:10.1016/b978-0-323-03437-1.50023-3 · Cited by 2
Androgens and Androgenic Progestins
Khosla, S. (2001) · Elsevier eBooks · doi:10.1016/b978-012470862-4/50077-5 · Cited by 2
Bhadouria, N., Huang, J. J., Augustin, J. A., Wang, B., Almeida, J. I., Kroon, T., Manolis, J., Lemonick, M. B., Seifert, A. C., Vashishth, D., et al. (2026) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2026.03.118 · Cited by 1
An unexpected cause of bilateral femoral neck fractures
Boog, P., Keizer, S. B., & Thomassen, B. J. W. (2012) · Current Orthopaedic Practice · doi:10.1097/bco.0b013e31826444c6 · Cited by 1
Geroscience and Management of Osteoporosis in Older Adults
Miedany, Y. M. E. (2022) · Springer eBooks · doi:10.1007/978-3-030-87950-1_19 · Cited by 1
Cauley, J. A. (2016) · Springer eBooks · doi:10.1007/978-3-319-25976-5_5 · Cited by 1
Klein, R. F. (1999) · Elsevier eBooks · doi:10.1016/b978-012528640-4/50022-8 · Cited by 1
Targeting the Osteoblast for Prevention and Treatment of Bone Diseases
Peterlik, M. (2004) · Springer eBooks · doi:10.1007/978-1-4471-3777-1_8 · Cited by 1
Severe Symptomatic Osteoporosis in Patients on Androgen Deprivation Therapy for Prostatic Carcinoma
Paterson, C. R., & Mole, P. A. (2002) · Scandinavian Journal of Urology and Nephrology · doi:10.1080/003655902320248317 · Cited by 1
EFFECT OF SELECTIVE ESTROGEN RECEPTOR MODULATORS (SERMS) ON GROWTH PLATE CARTILAGE
Karimian, E. (2010) · Figshare · Cited by 1
Estrogen Receptor β in the Pharmacology of Estrogens and Antiestrogens
Kuiper, G. G. J. M., Warner, M. N., & Gustafsson, J.-Å. (1999) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-60107-1_2 · Cited by 1
Androgene und Östrogene beim alternden Mann
Mock, K., & Lunglmayr, G. (1999) · Journal für Kardiologie (Krause & Pachernegg GmbH) · Cited by 1
Meier, C., Seibel, M. J., & Handelsman, D. J. (2010) · Elsevier eBooks · doi:10.1016/b978-0-12-374602-3.00035-3 · Cited by 1
Idiopathic Osteoporosis in Men
Bilezikian, J. P., Kurland, E. S., & Rosen, C. J. (1999) · Elsevier eBooks · doi:10.1016/b978-012528640-4/50020-4 · Cited by 1
Parsons, V., Juszczyk, D., Gilworth, G., Ntani, G., McCrone, P., Hatch, S. L., Shannon, R. R., Henderson, M., Coggon, D., Molokhia, M., et al. (2021) · Cited by 1
Metadata
- Authors
- Slemenda, C. W., Longcope, C., Zhou, L., Hui, S. L., Peacock, M., & Johnston, C. C.
- Affiliations
- Indiana University Indianapolis (US)
- University of Massachusetts Chan Medical School (US)
- Indiana University School of Medicine (US)
- Indiana University Bloomington (US)
- ORCID
- Venue
- Journal of Clinical Investigation
- Published
- 1997-10-01
- Volume
- 100
- Issue
- 7
- Pages
- 1755-1759
- ISSN
- 0021-9738 (ISSN-L)
- PMC
- PMC508359
- OpenAlex
- W1993231839
- Cited by
- 455
- References
- 28
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 2 · 2023: 6 · 2022: 8 · 2021: 7 · 2020: 7 · 2019: 9 · 2018: 7 · 2017: 6 · 2016: 8 · 2015: 8 · 2014: 6 · 2013: 7 · 2012: 16
- FWCI
- 24.09
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Clinical Investigation (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5p01ag005793-15)
- National Institute on Aging (P01-AG-05793)
- National Center for Research Resources (M01RR000750)
- Topics
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
- Keywords
- sex steroids, bone mineral density, older men, serum estrogen, estradiol, testosterone, sex hormone-binding globulin, bone mass, body weight, male skeleton
- MeSH terms
- Aged, Androgens, Body Constitution, Dehydroepiandrosterone, Estradiol, Estrogens, Estrone, Humans, Longitudinal Studies, Male, Middle Aged, Prospective Studies, Regression Analysis, Sex Hormone-Binding Globulin, Testosterone, Models, Statistical, Bone Density, Dehydroepiandrosterone Sulfate
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
