Cited by 433Advanced Glycation End Products researchChronic Kidney Disease and DiabetesRenal Diseases and Glomerulopathies

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Immunohistochemical colocalization of glycoxidation products and lipid peroxidation products in diabetic renal glomerular lesions. Implication for glycoxidative stress in the pathogenesis of diabetic nephropathy.

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Horie, K, Miyata, T, Maeda, K, Miyata, S, Sugiyama, S, Sakai, H, van Ypersole de Strihou, C, Monnier, V M, Witztum, J L, Kurokawa, K·1997·Journal of Clinical Investigation

DOI 10.1172/jci119853PMC PMC508511

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Abstract

Advanced glycation end products (AGEs) include a variety of protein adducts whose accumulation alters the structure and function of tissue proteins and stimulates cellular responses. They have been implicated in tissue damage associated with diabetic complications. To assess the possible link between AGE accumulation and the development of diabetic nephropathy (DN), we have examined the immunohistochemical localization of various AGE structures postulated to date, i.e., pentosidine, Nepsilon-(carboxymethyl)lysine (CML), and pyrraline, in diabetic and control kidneys. CML and pentosidine accumulate in the expanded mesangial matrix and thickened glomerular capillary walls of early DN and in nodular lesions and arterial walls of advanced DN, but were absent in control kidneys. By contrast, pyrraline was not found within diabetic glomeruli but was detected in the interstitial connective tissue of both normal and diabetic kidneys. Although the distribution of pyrraline was topographically identical to type III collagen, distribution of pentosidine and CML was not specific for collagen type, suggesting that difference in matrix protein composition per se could not explain heterogeneous AGE localization. Since oxidation is linked closely to the formation of pentosidine and CML, we also immunostained malondialdehyde (MDA), a lipid peroxidation product whose formation is accelerated by oxidative stress, assuming that local oxidative stress may serve as a mechanism of pentosidine and CML accumulation. Consistent with our assumption, diabetic nodular lesions were stained positive for MDA. These findings show that AGE localization in DN varies according to AGE structure, and suggest that the colocalization of markers of glycoxidation (pentosidine and CML) with a marker of lipid peroxidation reflects a local oxidative stress in association with the pathogenesis of diabetic glomerular lesions. Thus, glycoxidation markers may serve as useful biomarkers of oxidative damage in DN.

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Authors: Horie, K., Miyata, T., Maeda, K., Miyata, S., Sugiyama, S., Sakai, H., van Ypersole de Strihou, C., Monnier, V. M., Witztum, J. L., & Kurokawa, K.
Affiliations: Nagoya University (JP)
Tokai University (JP)
Kobe University (JP)
Chukyo Hospital (JP)
Case Western Reserve University (US)
University of California San Diego (US)
ORCID: Miyata, T
Maeda, K
Miyata, S
Sugiyama, S
Monnier, V M
Kurokawa, K
Venue: Journal of Clinical Investigation
Publisher: American Society for Clinical Investigation
Published: 1997-12-15
Volume: 100
Issue: 12
Pages: 2995-3004
ISSN: 0021-9738 (ISSN-L)
DOI: 10.1172/jci119853
PMC: PMC508511
OpenAlex: W2085341182
Cited by: 433
References: 56
Citations by year: 2026: 3 · 2025: 8 · 2024: 5 · 2023: 7 · 2022: 9 · 2021: 14 · 2020: 10 · 2019: 10 · 2018: 7 · 2017: 12 · 2016: 10 · 2015: 8 · 2014: 14 · 2013: 9 · 2012: 15
FWCI: 14.04
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Journal of Clinical Investigation (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
DIAL (Catholic University of Leuven) (submittedVersion, other-oa)
Funders: Japan Society for the Promotion of Science (96L00303)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Advanced Glycation End Products research
Health Sciences › Medicine › Nephrology › Chronic Kidney Disease and Diabetes
Health Sciences › Medicine › Nephrology › Renal Diseases and Glomerulopathies
Keywords: advanced glycation end products, glycoxidation, lipid peroxidation, diabetic nephropathy, pentosidine, carboxymethyllysine, pyrraline, malondialdehyde, oxidative stress, glomerular lesions, mesangial matrix, type III collagen, oxidative damage biomarkers
MeSH terms: Adolescent, Adult, Aged, Animals, Antibodies, Arginine, Collagen, Diabetes Mellitus, Type 2, Diabetic Nephropathies, Female, Humans, Immunoenzyme Techniques, Kidney Glomerulus, Lysine, Male, Malondialdehyde, Middle Aged, Nephrotic Syndrome, Norleucine, Pyrroles, Rabbits, Lipid Peroxidation, Glycation End Products, Advanced, Mice

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Immunohistochemical colocalization of glycoxidation products and lipid peroxidation products in diabetic renal glomerular lesions. Implication for glycoxidative stress in the pathogenesis of diabetic nephropathy.

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