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Elevated circulating amyloid concentrations in obesity and diabetes promote vascular dysfunction
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Aβ levels are elevated in patients with cardiometabolic diseases including obesity, T2D, and heart failure.
“However, Aβ levels are elevated in patients with cardiometabolic diseases including obesity, T2D, and heart failure.”
From BACE1: More than just a β‐secretase (2022) · cites this paper as [196]
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Neurovascular regulation in the normal brain and in Alzheimer's disease
Iadecola, C. (2004) · Nature Reviews Neuroscience · doi:10.1038/nrn1387 · Cited by 2,213
The clinical implications of endothelial dysfunction
Widlansky, M. E., Gokce, N., Keaney, J. F., & Vita, J. A. (2003) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(03)00994-x · Cited by 1,749 · cited 1×
“Importantly, impaired endothelium-dependent vasodilation is measurable before any morphological changes are detected in the vessel wall (14), indicating that reduced NO production and/or activity may be an important early event in vascular pathogenesis.”
Two amyloid precursor protein transgenic mouse models with Alzheimer disease-like pathology
Sturchler-Pierrat, C., Abramowski, D., Duke, M., Wiederhold, K.-H., Mistl, C., Rothacher, S., Ledermann, B., Bürki, K., Frey, P., Paganetti, P. A., et al. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.24.13287 · Cited by 1,507
The overlap between vascular disease and Alzheimer’s disease - lessons from pathology
Attems, J., & Jellinger, K. A. (2014) · BMC Medicine · doi:10.1186/s12916-014-0206-2 · Cited by 739 · cited 1×
“Indeed, cognitive decline and AD are associated with cerebrovascular and coronary atherosclerosis in humans, and people with AD exhibit pathological signs of vascular impairment in cerebral and peripheral vessels, indicating some commonality between peripheral and central disease mechanisms (2).”
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BACE1: More than just a β‐secretase
Taylor, H. A., Przemylska, L., Clavane, E. M., & Meakin, P. J. (2022) · Obesity Reviews · doi:10.1111/obr.13430 · Cited by 107
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Metadata
- Authors
- Meakin, P. J., Coull, B. M., Tuharska, Z., McCaffery, C., Akoumianakis, I., Antoniades, C., Brown, J., Griffin, K. J., Platt, F., Ozber, C. H., Yuldasheva, N. Y., Makava, N., Skromna, A., Prescott, A., McNeilly, A. D., Siddiqui, M., Palmer, C. N. A., Khan, F., & Ashford, M. L. J.
- ORCID
- Venue
- Journal of Clinical Investigation
- Published
- 2020-06-29
- ISSN
- 0021-9738
- 1558-8238
- PMC
- PMC7410081
- Cited by
- 22
- References
- 6
- Language
- en
- Funders
- British Heart Foundation (PG/15/44/315,4)
- Diabetes UK (12/0004458)
- Medical Research Council (MR/K003291/1)
- Diabetes Research & Wellness Foundation (DRWF PP/201)
- Innovative Medicines Initiative (IMI-2008/115006)
- Mark Kearney University of Leeds (RG/15/7/31521)
- Wellcome Trust (072960/Z/03/Z)
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